Latest technologies from Wayne State University

Disassembly Learning Catalyst (DLC)

ttoinfo@wayne.edu — Thu, 29 Jan 2026 13:37:59 GMT

Technology Summary This technology employs enhanced multilayer direct disassembly networks (MDDNs) derived from CAD assemblies to model and optimize product disassembly sequences. Using knowledge graphs converted from MDDNs, a generative adversarial network (GAN) framework with generative and discriminator components is trained to produce synthetic disassembly designs that improve component accessibility for efficient disassembly, especially considering component degradation. The system integrates collision detection, interference analysis, and node-edge attribute augmentation to crea...

Insulin Crystals Removal Platform

ttoinfo@wayne.edu — Tue, 27 Jan 2026 13:37:46 GMT

Description: A platform technology for improving insulin delivery by removing insulin-derived fibrils through polyester membrane filtration. This invention employs membrane filters integrated into insulin delivery systems to selectively remove insulin-derived fibrils (IDFs) from insulin formulations. By filtering out fibrils while preserving active insulin concentration, it enhances the stability, safety, and effectiveness of insulin therapy, especially in continuous subcutaneous insulin infusion (CSII) systems, including automated insulin delivery (AID). Key Advantages: ...

“Smart” Glucose-Responsive Insulin

ttoinfo@wayne.edu — Fri, 09 Jan 2026 09:43:29 GMT

Technology Summary A "smart" or glucose-responsive insulin that can automatically respond to changes in a patient’s blood stream and help treat patients with type 1 diabetes. This technology comprises compositions that integrate a zwitterionic polymer, insulin moieties, saccharide moieties, and saccharide binding molecules to create a glucose-sensitive system. The compositions are engineered to release insulin in response to elevated glucose concentrations, improving diabetes management by maintaining insulin bioactivity and optimizing pharm...

Human Tissue-Engineered Inflammatory Model of Atherosclerosis

ttoinfo@wayne.edu — Fri, 09 Jan 2026 08:41:04 GMT

A novel, biologically engineered human blood vessel model that accurately replicates atherosclerosis for advanced preclinical research. Technology Summary This technology creates the first authentic human tissue-level in vitro model of atherosclerosis using a proprietary ring stacking method to build three-layered blood vessels entirely from human cells. It replicates key pathological steps of the disease, enabling realistic study of inflammatory responses and plaque formation, overcoming limitations of animal and simplistic in vitro models. ...

Modified DGA-Associated Sorbent Media for Rare Earth Element Recovery

ttoinfo@wayne.edu — Tue, 06 Jan 2026 10:29:58 GMT

A novel hydrophobically modified diglycolamide (DGA) sorbent on organosilica enables selective, efficient, and sustainable recovery of rare earth elements (REEs) from low-grade and waste sources. Technology Summary This technology features a modified diglycolamide ligand, notably N,N,N,N-Tetraoctyl Diglycolamide (TODGA), functionalized with hydrophobic alkane chains and immobilized on a swellable organosilica support to create a stable sorbent media. It selectively extracts heavy rare earth elements (HREEs) from complex acidic solutions such as coal fly ash, phosphate fertilizers, and e-wast...

Transgenic Mouse Model for Marfan Syndrome Research

ttoinfo@wayne.edu — Tue, 23 Dec 2025 04:36:16 GMT

Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency and connective tissue abnormalities. Developed using CRISPR/Cas9 gene-editing, the model replicates the multisystemic clinical features of the disease, facilitating in-depth investigation of disease mechanisms and therapeutic strategies. . ...

Portable Thermal Nitric Oxide Generation Technology

ttoinfo@wayne.edu — Mon, 15 Dec 2025 14:05:22 GMT

Novel chemical composition that enables pure NO gas release upon heat. Technology Summary This technology enables safe, efficient, and portable generation of medical-grade nitric oxide (NO) by thermally activating a bench-stable solid-state NO-releasing molecule embedded in a porous polymer matrix. FDA approved Inhaled nitric oxide therapy is currently limited to hospital settings to account for controlled delivery. This technology produces NO free of toxic NO2 contamination under ambient air, making it suitable for home, emergency, and remote healthcare appl...

Low-Cost High-Performance 3D LiDAR Imaging System

ttoinfo@wayne.edu — Mon, 15 Dec 2025 13:46:19 GMT

Description: This innovative 3D imaging system uses time-of-flight measurement of photons with a conventional global shutter CMOS camera to generate accurate distance data converted into brightness levels. It includes a laser source, camera, delay generator, master trigger, and electronic control unit (ECU) which together capture and average multiple jittered frames to produce normalized intensity images. These images are calibrated to create high-precision 3D point clouds capable of detecting objects over 50 meters away. The design focuses on simplicity, cost-effectiveness, and scalability, ...

Methods For The Prediction Of Drug Penetration and Exposure In The Human Brain

ttoinfo@wayne.edu — Thu, 06 Nov 2025 11:02:13 GMT

Description: A novel 9‑compartment physiologically based pharmacokinetic model was developed and fully validated for prediction of heterogeneous drug distribution and exposure in the human central nervous system (CNS) and brain tumors. The 9-compartment model accounts for the general anatomical structure and pathophysiology of the human CNS and brain tumors. It enables prediction of drug concentration – time profiles (i.e., pharmacokinetics) in different regions of the brain, tumor, and cerebrospinal fluid. The model was vigorously validated with clinically observed data. SpatialC...

Method for Constructing a Lateral Material Sourcing Database

ttoinfo@wayne.edu — Thu, 06 Nov 2025 09:31:02 GMT

Description: This technology revolutionizes traditional supply chains by focusing on hyperlocal sourcing of materials typically overlooked or discarded within communities. Using advanced AI to analyze public and contextual data alongside geographic information—such as addresses, coordinates, and regional identifiers, the tool identifies novel sourcing opportunities embedded in local environmental, cultural, and social contexts. It connects users with localized waste streams and surplus resources, enabling sustainable material discovery integrated with community infrastructure. Key Adva...

Thermal Atomic Layer Etching of Cobalt and Other Transition Metal Films

ttoinfo@wayne.edu — Tue, 28 Oct 2025 10:30:31 GMT

A novel stepwise chemical etching method for precise and controlled removal of metal surfaces using protic compounds. Technology Summary This technology introduces a method for etching metal or element surfaces by initially contacting the surface with a protic compound to create a modified layer, followed by exposure to a protic ligand-forming compound that reacts to form and remove a volatile metal- or element-containing compound, resulting in controlled partial etching of the surface. The process may be conducted in cycles and is suitable for use with ALD (Atomic Layer Deposition) ...

High Capacity Hybrid Frame-Wall Intended for Cold-formed Steel Construction

ttoinfo@wayne.edu — Wed, 22 Oct 2025 12:02:52 GMT

High-Capacity Hybrid Frame-Wall Intended for Cold-formed Steel Construction WSU Tech#: 23-1735 Technology Summary This innovative hybrid frame-wall system integrates cold formed steel columns that support gravitational loads with a steel braced frame embedded within the wall plane to resist lateral forces. The frame uses concentric and eccentric connections between hollow structural steel chords and bracing elements, combined with semi-rigid connections to a concrete slab. Bracing incorporates cold formed steel straps and non-prestressed strands, delivering enhanced pushover resp...

Multi-parametric Acoustic, Optical and Mechanical Imaging of Cervical Tissue Insufficiencies to Predict Preterm Birth

ttoinfo@wayne.edu — Wed, 10 Sep 2025 13:25:01 GMT

An enhanced image-guidance system that integrates ultrasound and photoacoustic into existing ablation systems to provide an enhanced image-guidance system for identification of cervical tissue changes during pregnancy and postpartum. Technology Summary Preterm delivery is a main cause of perinatal morbidity and mortality worldwide, which is associated with a significant healthcare cost spent on prematurity. Cervical remodeling during pregnancy is a critical process that can lead to complications such as preterm birth (PTB). This technology introduces a novel multi-parametric approach combin...

Using Nanotechnology to Target Aggressive Cancers

ttoinfo@wayne.edu — Fri, 22 Aug 2025 07:12:01 GMT

A modified gold nanoparticle is used to target aggressive triple negative breast cancer and melanoma by inhibiting RAD6 which is overexpressed in aggressive and chemo resistant cancers. Technology Summary This technology utilizes gold nanoparticles (GNPs) conjugated with a small molecule inhibitor (SMI#9) designed to target RAD6, a protein overexpressed in aggressive and chemo resistant cancer cells. GNPs are preferentially taken up by cancer cells when injected into the blood stream and their safety has been demonstrated in human clinical trials. By blocking RAD6&r...

Wearable Ear Sensor for continuous health monitoring.

ttoinfo@wayne.edu — Tue, 15 Jul 2025 09:32:41 GMT

WSU researchers have developed an ultrasmall, low power technology to sense heart rate, pulse wave velocity (PWV), blood oxygenation and blood pressure. The device uses a digital optical proximity sensor (OPS) which integrates LED light sources, detectors and signal processors into a 4mm square and consumes <200 microwatts, which represents a 10X smaller size and >10X lower cost than state of the art sensors. This technology could lead to the development of the smallest and cheapest wireless heart rate sensor on the market. These improvements will lead to a 24 hour wearable heart ...

CMOS Laddered Inverter Ring Oscillator

ttoinfo@wayne.edu — Tue, 19 Oct 2021 10:02:23 GMT

Low-Power, Multi-Phase, CMOS-based Ring Oscillator Circuit Background: CMOS technology is used for constructing integrated circuit (IC) chips, including microprocessors, microcontrollers, memory chips (including CMOS BIOS), and other analog and digital logic circuits. A CMOS ring oscillator circuit is an odd number (N) of inverting stages connected in series with the output fed back to the input as shown in the figure below. The ring oscillator and related circuits are fundamental building blocks used in a broad spectrum of applications such as clock oscillators in computers and carrier fr...

Discovery of Well Defined Sulfated Glycopolymers as Specific Heparanase Inhibitors for Cancer Therapeutics

ttoinfo@wayne.edu — Wed, 02 Dec 2020 09:49:32 GMT

The remodeling of the extracellular matrix has been shown to be highly upregulated in cancer and inflammation and is critically linked to the processes of invasion and metastasis. The finding that heparanase is elevated in a wide variety of tumor types and is subsequently linked to the development of pathological processes has led to an explosion of therapeutic strategies to inhibit its enzyme activity. Heparanase is a heparin sulfate polysaccharide degrading endoglycosidase enzyme that is being targeted in cancer patient clinical trials. This strategy is supported by the fac...

A method to induce ferroptosis and to downregulate androgen receptor/androgen receptor splice variant in prostate cancer cells

ttoinfo@wayne.edu — Thu, 19 Nov 2020 09:50:43 GMT

Prostate cancer (PCa) effects approximately three million men in the United States every year. About 10-20% of the cases of prostate cancer are castrate-resistant prostate cancer (CRPC). This form of PCa is highly resistant to what Is known as androgen depletion therapy and is often fatal. All types of PCa are sensitive to androgen receptor signaling making this receptor the target of existing therapies. Some cancers initially respond to those therapies but then change behavior and become aggressive, these are CRPC. This technology is a novel drug combination ther...

Identification of Galeterone's mechanism of action leading to novel treatment therapies for castrate resistant prostate cancer (CRPC)

ttoinfo@wayne.edu — Thu, 19 Nov 2020 06:54:23 GMT

Castration-Resistant Prostate Cancer (CRPC) or Hormone Refractory Prostate Cancer (HRPC), is a type of prostate cancer that typically recurs after administering androgen deprivation therapy (ADT). The need for effective therapies for these difficult to treat cancers is gaining prominence in the prostate cancer market. The global CRPC market is poised to expand at a significant pace, owing to high unmet clinical need, limited survival benefits, growing prevalence rates and fast emerging treatment modifications. The market growth would pivot around the novel breakthrough treatments respons...

Ultra-Specific and Ultra-Sensitive Platform for Highly-Reliable and High-Precision SARS-CoV-2 Detection

ttoinfo@wayne.edu — Tue, 26 May 2020 11:42:37 GMT

Background:The technology described is based on the use of two unique sets of detection molecules that are specific to a protein contained in the viral shell of SARS CoV-2 and Covid-19 that is unique from other known common cold causing coronaviruses. The proposed system uses two different fluorescent probes for two different regions of the viral shell protein gene. The two probes fluoresce at widely different wavelengths that can be detected simultaneously with the proper equipment. Benefits:The use of PCR reduces the size of the sample needed for accurate detection. T...

Disulfide by Design 2.0: A web-based tool for disulfide engineering in proteins

ttoinfo@wayne.edu — Wed, 29 Apr 2020 09:54:00 GMT

Background:Immunoinformatics employs a computer-driven approach to identifying fragments of the target pathogen that would provide a suitable vaccine, avoiding potential safety concerns from the more traditional approach of using whole pathogens. Immunoinformatics now plays a crucial role in vaccine design, immunodiagnostic development, and antibody production. Previously, vaccine development depended exclusively on immunological experiments which are relatively expensive and time-consuming. However, recent advances in the field of immunological bioinformatics have provided feasible tool...

Microfluidic platforms for live-cell imaging and bio/pathomimetic tissue models

ttoinfo@wayne.edu — Mon, 06 Apr 2020 14:28:52 GMT

Background:Methodologies to image and quantify tissue models using high-content analysis (HCI) and functional analyses of 3D avatars are needed as such avatars better recapitulate the phenotype of pathobiological processes and better predict efficacy of, and resistance to, a wide variety of therapies. Furthermore, changes in morphometry, viability, proliferation, proteolysis and invasive phenotype can be visualized in 3D cultures as can spatiotemporal and dynamic interactions among cells in 3D cultures/co-cultures. Technology:Dr. Sloane’s laboratory has pioneered techniques fo...

SALT-FORMULATED VALPROATE AS A TOPICAL ANTI-FUNGAL TREATMENT

ttoinfo@wayne.edu — Mon, 06 Apr 2020 09:40:28 GMT

In 2018, the global antifungal drugs market size was valued at USD 11.6 billion. Generally speaking, 54.3% of sales are prescription and 45.7% is over-the counter OTC/Alternative. It is anticipated that the OTC/Alternative portion of the global antifungal market will continue to grow. Science is indicating that both the number of systemic infections and drug resistance is on the rise. There is a wide effect of fungal infections, ranging from minor seasonal allergic reactions to a potentially fatal invasive/systemic disease, the importance of having efficacious antifungal medic...

Polyclonal and Monoclonal Antibodies to TPH1 and TPH2

ttoinfo@wayne.edu — Wed, 04 Dec 2019 12:23:07 GMT

This technology is a set of antibodies that is used with immunohistochemistry techniques to differentiate between tryptophan hydroxylase 1 and 2, enabling scientists to study how the two enzymes are differentially regulated. Technology Summary The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode enzymes in serotonin biosynthesis. Variants in both genes have been implicated in several neuropsychiatric disorders and personality traits. Prior to the discovery of TPH2 in 2003, it was thought that serotonin levels in the central nervous system were regulated by serotonin sy...

Drugs that disrupt interactions between ELK1 and the androgen receptor to suppress growth of both early stage and castration resistant prostate cancer

ttoinfo@wayne.edu — Tue, 22 Oct 2019 11:23:01 GMT

Background:Prostate cancer is the second-most commonly diagnosed cancer among men and the fifth most common cause of male cancer death worldwide. Although tumors are often initially sensitive to medical or surgical therapies that decrease levels of testosterone, continued disease progression generally represents a transition to the lethal variant. In spite of the fact that prostate tumors are generally depend on the androgen receptor (AR) signaling WSU research is focused on developing novel and proprietary therapy for the treatment of early stage and castrate resistant prostate ca...

EL4-E2 Cell Line

ttoinfo@wayne.edu — Tue, 17 Sep 2019 12:04:48 GMT

This technology is a targeted anti-HER2 cell line that can be used as a research tool to develop HER2‑based vaccines for the treatment of aggressive breast cancer. Background & Unmet Need: The human epidermal growth factor 2 (HER2) is overexpressed in approximately 20-30% of all breast cancers and is associated with more aggressive and proliferative tumors. Many patients with HER2‑overexpressing metastatic breast cancer will benefit from initial treatments such as administration of trastuzumab and other targeted therapies; however, most patients will eventually...

Transgenic Mice Carrying Wild Type Human Her-2 Under the Whey Acidic Promoter

ttoinfo@wayne.edu — Tue, 17 Sep 2019 12:02:47 GMT

This transgenic line expresses the human ERBB2 (HER2) gene in mammary gland and brain, displays tolerance to ERBB2 antigen and may be useful in testing ERBB2-based vaccines and immunotherapies. Technology Summary Her-2 positive breast cancer is a breast cancer that is positive for a protein called human epidermal growth factor receptor 2 (Her-2). Presence of Her-2 promotes the growth of cancer cells and is caused by a genetic mutation. 1 in 5 breast cancers are labelled as Her-2 positive; these types of cancers tend to be more aggressive and less ...

Interactive EMR - IA-EMR

ttoinfo@wayne.edu — Thu, 08 Aug 2019 09:31:46 GMT

Our researchers have developed the connection of Automatic Speech Recognition to electronic medical records to enhance the physician/patient encounter. Background & Unmet Need: The traditional encounter in healthcare consists of a communication, mostly face-to-face, between the healthcare provider and the sick patient. Arriving at an accurate diagnosis is fundamental to this interaction. A detailed history of illness in the context of each patient’s pertinent past history, along with a comprehensive physical examination is imperative to narrow the list of different di...

Ambulatory systemic blood pressure telemonitoring

ttoinfo@wayne.edu — Tue, 28 Nov 2017 11:44:57 GMT

A non-invasive sensor method to determine ambulatory systemic blood pressure in the adult or pediatric population through the use of telemonitoring. Background & Unmet Need: Currently, non-invasive systems to measure blood pressure suffer from inaccuracies. They can vary significantly and there is no easy-to-use accurate way to determine ambulatory blood pressures in children for an extended period of time. Technology Description: Our researchers have developed a device that measures systemic blood pressure rather than peripheral vascular pressures. The new method ...

SH80 Combinations

ttoinfo@wayne.edu — Thu, 03 Aug 2017 08:51:08 GMT

BackgroundSH35/SH80 evolved from an effort to improve upon the anti-tumor activity of XK469. XK469 is a compound, currently in Phase 1 clinical trials. The clinical trials include patients with bladder, breast, colorectal, esophageal, head and neck, kidney, liver, lung, mesothelioma, pancreas and sarcoma cancers. Moving a chlorine atom from one position to another destroys the anti-tumor activity and makes the compound an herbicide. The inventors substituted several different atoms in a specified region of XK469 to determine if anti-tumor activity was enhanced or decrea...

Generation of gp78 null mice

ttoinfo@wayne.edu — Fri, 19 May 2017 08:35:34 GMT

Generation of gp78 null mice WSU Tech#: 15-1291 Technology: Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis, and cancer. It suggests that gp78 is a regulator of normal liver homeostasis and a tumor suppressor in human liver. Technology Summary: gp78 was at first identified as a receptor of autocrine motility factor (AMFR) and was subsequentl...

Sarcoidosis and TB Biomarkers

ttoinfo@wayne.edu — Fri, 19 May 2017 08:35:29 GMT

Sarcoidosis and TB Biomarkers WSU Tech#: 15-1276 Technology Summary: This technology includes a new method for generating phage libraries and clones that are useful in discovering biomarkers from human blood samples. The inventors looked at the change in immune cells versus that of the infected tissue (BAL and blood) used this to generate biomarkers for Sarcoidosis and TB. A total of 115 sarcoid sera, 64 healthy control sera and 17 TB sera were tested on the 1152 phage peptide microarray. Bioinformatically analyzed data identified 259 antigens with the highest...

"Generation of an affinity-purified rabbit anti-CREBH polyclonal antibody"

ttoinfo@wayne.edu — Fri, 19 May 2017 08:35:26 GMT

Generation of an Affinity-Purified Rabbit Anti-CREBH Polyclonal Antibody WSU Tech#: 15-1271Technology Summary: CREBH (also called CREB3L3) is a stress-inducible metabolic regulator that plays key roles in hepatic lipolysis, fatty acid oxidation, gluconeogenesis, and lipogenesis. CREBH is critically involved in fatty liver disease and its associated metabolic syndrome. CREBH is becoming a hot topic in the research fields of stress response and metabolism and an increasing numbers of research teams are working on this target/biomarker. CREBH is a liver-specific bZIP transc...

Lyophilized Ready to Use & Load PCR Master Mix

ttoinfo@wayne.edu — Fri, 19 May 2017 08:35:03 GMT

PCR and Enzyme Lyophilization and Stabilization Formulation WSU Tech#: 13-1183Technology Summary: Wayne State University has discovered methods in which to formulate PCR related enzymes and reagents so they can be lyophilized. This stabilizes the proteins, nucleotides and buffers so they can be shipped and stored at room temperature. Our research shows that they can be stored at room temperature for at least a year and reconstituted with water or buffer without any loss of activity or efficiency. This can save money and valuable refrigerator/freezer space by allowing th...

GENERATION OF 5-FLUOROURACIL + OXALIPLATIN RESISTANT COLON CANCER CELLS: A TOOL TO STUDY CANCER RECURRENCE AND DRUG RESISTANCE

ttoinfo@wayne.edu — Fri, 19 May 2017 08:34:55 GMT

Generation of 5-Fluorouracil + Oxaliplatin Resistant Colon Cancer Cells WSU Tech#: 13-1154 Technology Summary: A significant obstacle for the successful management of patients with colorectal cancer (CRC) is intrinsic drug resistance or, in patients who respond to chemotherapy, acquired drug resistance. Drug resistance can occur through a variety of mechanisms, including alterations in drug influx, drug efflux, intracellular metabolic activation, and intracellular catabolism, or through alterations in the drug's target. In addition, alterations in genes involved in the regulation of the...

Vaginal microbiome snapshot (VMS)

ttoinfo@wayne.edu — Fri, 19 May 2017 08:34:52 GMT

Vaginal Microbiome Sanpshot; a Method for Diagnosing Bacterial Vaginosis and Other Vaginal Disorders WSU Tech#: 13-1141 Technology Summary: Bacterial vaginosis (BV) is a disease of the vagina caused by an imbalance of naturally occurring bacterial flora and is often confused with yeast infection (candidiasis) or infection with Trichomonas vaginalis (trichomoniasis). The main and unique feature of Lactobacillus Relative Content (LbRC) technology, is that it measures the level of dominance of Lactobacillus species relative to ALL BV-associated anaerobes in the vaginal ...

A method to identify patients at risk for subsequent stillbirth in the third trimester

ttoinfo@wayne.edu — Fri, 19 May 2017 08:34:45 GMT

A Method to Identify and Treat Patients at Risk for Stillbirth in the 3rd TrimesterWSU Tech#: 12-1113Technology Summary: This invention is a method of identifying patients at risk for subsequent stillbirth (only due to placental related disorder) in the third trimester using a maternal blood sample. A blood sample would be obtained at the beginning of the third trimester of pregnancy (30-34 weeks) and the concentrations of three analytes would be measured. The compounds are: placental growth factor (PlGF), soluble vascular endothelial growth factor receptor-1 (sVEGFR-1 or sflt-) and solu...

Long non-protein-coding RNA molecules as therapeutics for epilepsy.

ttoinfo@wayne.edu — Fri, 19 May 2017 08:34:39 GMT

Long Non-Coding RNA Molecules as Therapeutics for Epilepsy WSU Tech#: 12-1089 Technology Summary: Long Non-coding RNA (lncRNA) were first described in 2002 from mouse, making this a relatively new technology. lncRNA transcripts far exceed the number of protein coding mRNAs in the mammalian transcriptome, but in lower copy numbers. Inventors have performed in vitro system perturbations of a subset of these lncRNA-mRNA cis-pairs and trans-pairs, showing that by modulation (increasing or decreasing) the lncRNA level, we can directionally and specifically alter the level o...

Sentinel Cell

ttoinfo@wayne.edu — Fri, 19 May 2017 08:34:19 GMT

Sentry Cell (Macrophage Hazardous Material Detection) WSU Tech#: 10-991 Technology Summary: This technology is designed around an isolated cell system for the detection of an energetic material comprising of an isolated stationary macrophage cell isolated from a vestibular labyrinth of a Opsanus sp. This macrophage cell is plated in culture and when contacting a substrate it is sensitive to, the cell said cell exhibiting a set of cellular responses characteristic of and specific to said energetic material. Thus it not only detects the presen...

CARP-1/CCAR1 Functional Mimetics (CFMs): Novel small molecule suppressors of human breast cancer cell growth.

ttoinfo@wayne.edu — Fri, 19 May 2017 08:34:12 GMT

BackgroundCARP-1 (Cell cycle and apoptosis regulator protein) is a regulator of cell growth signaling. CARP-1 plays an important role in apoptosis (cell death) induction in human breast cancer (HBC) cells in the presence of the chemotherapy agent Adriamycin. The researchers have found that CARP-1 inhibits cell growth by binding with the anaphase promoting complex (APC)-2 protein. Since breast cancers often have dysregulated cell cycle signaling, the researchers hypothesize that CARP-1 mimetics that target APC-2/cell cycle signaling will inhibit H...

New Methods for the Treatment and Prevention of Preterm Labor

ttoinfo@wayne.edu — Thu, 18 May 2017 08:30:40 GMT

PRODUCT/SERVICE ‘SOLUTION’ DESCRIPTION Pre-term birth (delivery before 37 weeks of gestation) is a serious health problem in the US. and the world, representing a leading cause of infant death and long-term illnesses. Pre-term birth accounts for nearly 11% of all births and 17% of all infant deaths in the U.S., costing >$25 billion annually. Studies have estimated that up to 30−40% of pr-eterm births are caused by maternal inflammation. To prevent pre-term birth triggered by maternal inflammation, Wayne S...

CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines

ttoinfo@wayne.edu — Mon, 30 Jan 2017 10:40:25 GMT

CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines WSU Tech#: 15-1256 Technology Summary: CJ4.1A and CJ4.3C are rat conjunctival epithelial cell lines. The cell lines were developed to investigate antigen translocation across a mucosal barrier. Conjuctival epithelial cells from Fischer 344 rats were immortalized with pSV3(neo) resulting in cell lines CJ4.1A and CJ4.3C. Cells express SV40 T-Antigen, conjunctiva specific cytokeratin 4, goblet cell specific cytokeratin 7 and negative for epithelial cell-specific cytokeratin 12. The cells were passaged over 60 times with e...

Addressing Co-Channel Interference with PRK-Based Scheduling for Predictable Link Reliability in Wireless Networked Sensing and Control

ttoinfo@wayne.edu — Wed, 25 May 2016 09:21:37 GMT

Technology Description Wayne State researchers have created a wireless networking method that ensures predictable communication reliability as needed by 5G, Internet of Things, cyber-physical systems, as well as their applications in domains such as industrial automation, smart energy grid, and connected and automated vehicles. In particular, the method solves the 40+ years old open problem of co-channel interference control through field-deployable approaches. Co-channel interference is when two or more wireless network nodes (e.g., wireless access points, laptops, and smart phones) tra...

Topical IL-1Ra (anakinra) in the form of gel to treat persistent diabetic skin and corneal wounds

ttoinfo@wayne.edu — Wed, 25 May 2016 09:14:21 GMT

BackgroundAnakinra (aka. Kineret) is a recombinant human IL-1Ra that was developed by Amgen. It is currently used to treat moderately to severely active rheumatoid arthritis, but also treats neonatal-onset multisystem inflammatory disease (NOMID). Anakinra is given as an IV dose and the drug is no longer under patent. The properties of Anakinra are well known, and it is commercially available as a generic drug. Our inventors are working on reformulating the generic drug, from an IV injected liquid to a topical gel. The new Anakinra gel formulation could be used di...

Antibacterial activity of natural compounds and their synthetic analogue: A potential new antibiotic with potent activity against multiple drug resistant bacterial pathogens

ttoinfo@wayne.edu — Tue, 12 May 2015 06:48:47 GMT

Our researchers have developed novel compounds that are potential new anti-infective therapeutics useful for treatment against the deadly bacteria MRSA (methicillin-resistant Staphylococcus aureus), VRE (vancomycin-resistant Enterococcus faecium), and several other well-known common infectious agents.Background & Unmet Need:Before antibiotics became available in the 1940s, the major causes of death were infectious diseases. The availability of antibiotics changed that, but organisms have evolved resistance mechanisms faster than we have developed new antibiotics. The financial ...

Whole body model of a 10-year-old child for pediatric injury prediction

ttoinfo@wayne.edu — Fri, 11 Oct 2013 08:07:14 GMT

Technology A computational whole body 10-year-old (YO) FE (Finite Element) model which is anatomically accurate based on the clinical images. The model was composed ofhigh quality elements for accurate stress/strain predictions and possessed high biofidelity to accurately predict body responses under external mechanical loadings. Preliminary verification ofthe FE model against available cadaver test data was also performed. This invention is a new simulation finite element model consisting of detailed organs definition, tissues, ligaments, muscles of a 10-year-old child. The model was cr...

Ruthenium-based caging of nitrile-containing enzyme inhibitors

ttoinfo@wayne.edu — Mon, 29 Apr 2013 10:33:19 GMT

Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the pathophysiology of diseases such as osteoporosis, autoimmune disorders, and cancer. Using the method developed at WSU, in vitro studies confirmed light activated inhibition of the cysteine protease papain in series of human cell lysates and cult...

Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging

ttoinfo@wayne.edu — Fri, 26 Apr 2013 12:21:02 GMT

Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI produces ions similar to Electrospray Ionization (ESI) methods without the need for a solvent or voltage. With higher charged ions, LSI extends the mass range (m/z) for high MW analytes which is typically limited in high resolution mass spec instru...

Next Generation MRI Contrast Imaging Agent

ttoinfo@wayne.edu — Thu, 02 Aug 2012 12:40:28 GMT

WSU has developed a new class of contrast agents that are effective at ultra-high field strengths (>3 tesla) in magnetic resonance imaging (MRI) where current clinical agents severely decline in effectiveness. Our new agents are based on the metal Eu(II) which is novel compared to current agents that are based on Gd(III). The difference between the two metals leads to increase in effectiveness (higher relativity) with increasing field strength between 1.4 and 9.4 tesla for Eu(II) agents where current Gd(III)- based technology decreases rapidly in effectiveness over the same field strength r...

Intelligent Autonomous Camera Control for Robotics with Medical, Military, & Space Applications

ttoinfo@wayne.edu — Tue, 24 Jul 2012 13:10:59 GMT

Currently, during robotic surgery the surgeon must interrupt the operation and shift controls to move the camera arm of the robot, causing a distraction for the surgeon. Researchers from Wayne State University’s Electrical and Computer Engineering Department and the School of Medicine have jointly developed a new method for camera movement based on internally tracking (via kinematics of the robot) the locations of the end-effectors and automatically moving the camera arm to follow and zoom into the region where the surgeon is working. The system can be configured to ensure that the tracked e...

Marangoni Optofluidic Tweezers (MOT)

ttoinfo@wayne.edu — Wed, 23 Nov 2011 07:43:33 GMT

There is currently a great deal of interest in using small droplets as containers for chemical reactions. Optical methods for droplet manipulation are attractive because they offer control without an on chip structure; however forces from optical tweezers tend to be in the pN range. Wayne State University researchers have developed a new method to trap liquid droplets using light. Laser light is focused on the surface of a drop using a lens. The light is a strong enough intensity to heat up the surface of the liquid droplet, generating thermocapillary flow which align...

Dispersion-optimized Silicon nanoparticle (SiNP)/Graphene composite anode for high performance Lithium ion battery (LIB)

ttoinfo@wayne.edu — Mon, 07 Nov 2011 10:04:39 GMT

WSU researchers have invented a novel method to produce dispersion-optimized SiNP within a conducting Graphene matrix forming a standalone composite anode material. The method creates small clusters to lone particle distributions maximizing the nanomaterial properties of SiNP yielding anodes with improved capacity retention and rate performance. It utilizes combinations of high power/energy sonics and chemical surfactants that warrant proper distribution of non-agglomerated SiNPs. Regular ultrasonication is the principal preparative technique used to disperse Si particles in current ...

First Row Transition Metal Diazadiene Film Growth Precursors

ttoinfo@wayne.edu — Mon, 02 May 2011 10:48:18 GMT

Technology Overview Wayne State University researchers have developed a new class of thermally stable, volatile transition chemical compounds that have desirable properties for the growth of thin films of transition metal-containing materials. These novel film precursors have high potential for use in the growth of thin films by chemical vapor deposition (CVD), atomic layer deposition (ALD), and related film growth technologies. ALD processes require precursors that are thermally stable at the deposition temperature. Currently there are few precursors avail...

Vibro-acoustic metamaterial with mass and flexible stem array

ttoinfo@wayne.edu — Mon, 02 May 2011 10:42:22 GMT

WSU researchers have developed a novel device combining the effects of negative effective elastic modulus and negative effective mass, acting as local resonators that can damp out vibrations and sound at multiple frequencies. This class of metamaterials has the superior ability to attenuate sound and have a much greater ability to block dynamic disturbances. The design of the material can be tailored to cover a wide range of vibro-acoustic loads that cannot be handled by current conventional materials. Technology Overview:Current dampening materials consist of foams and adhesives with ...

Concussion Reduction Helmet

ttoinfo@wayne.edu — Thu, 10 Mar 2011 07:16:45 GMT

Wayne State University Researchers have designed a football helmet to reduce the likelihood of a cerebral concussion to the wearer during blunt impact with another player or the ground. The helmet shell and interior padding are tuned using a computer model of the head and helmet to reduce the strain experienced by the brain during impact. Commercial ApplicationsStudies on the risks of long-term brain damage to American Football players have recently raised awareness of the need for improvements in protective equipment. Our helmet design has the potential to improve upon the s...

Guidance and Control System for Under Actuated Marine Surface Vessels

ttoinfo@wayne.edu — Tue, 21 Sep 2010 06:58:36 GMT

WSU researchers have developed a guidance system that yields a faster convergence rate of the ship to its desired trajectory than existing systems. The new algorithm varies the radius in the guidance algorithm exponentially as opposed to linear variations in existing schemes. This was done to prevent the system from over-reacting for small cross track errors and to force the ship to operate under steeper desired heading angle than the one specified by existing systems. As a consequence, ships using the new guidance system will converge faster to their desired trajectories than...

Fuel Injector to Work as an Ionization Sensor and as an Injection Signal Detector in Electronically Controlled Fuel Injection Systems in Diesel and Direct Injection Gasoline Engines

ttoinfo@wayne.edu — Fri, 04 Jun 2010 07:01:31 GMT

Wayne State researchers have created an invention which uses one element in the engine, the fuel injector, to perform four tasks, injecting fuel, acting as an injection pulse detector, operating as a fuel injector malfunction detector and working as an ion sensor without modifying the fuel injector. Internal combustion engine control has become more important than ever, as a result of the increasing restrictions on emissions from fossil fuel combustion. Minimizing the number of sensors and maximizing the engine performance and reliability is a goal for every engine manufacturer. In th...

Ultra-Sensitive Piezoresistive Accelerometer Based on Decoupled Piezoresistors

ttoinfo@wayne.edu — Tue, 11 May 2010 11:52:47 GMT

Ultra-sensitive piezoresistive accelerometer that has advantages over traditional piezoresistive accelerometers in both the sensitivity and minimum detectable acceleration.Wayne State University researchers have developed an ultra-sensitive piezoresistive accelerometer that has advantages over traditional piezoresistive accelerometers in both the sensitivity and minimum detectable acceleration. Traditional piezoresistive accelerometers face challenges in applications where high bandwidth and high resolution are required simultaneously such as respiratory sound monitoring. Commercial Applicatio...

Microfluidic Particle Concentration and Separator

ttoinfo@wayne.edu — Tue, 11 May 2010 11:52:45 GMT

Researchers at the Wayne State University Smart Sensors and Integrated Microsystems (SSIM) laboratory have developed a micro-scale concentrator and separator applicable to several microfluidic applications. Initially the device was developed to concentrate and separate bacteria from other impurities to test water quality however the micro separator could have much broader applicability. The device and its fabrication method are unique. The device is composed of a large array of identical flow units arranged in a stagger and cascade fashion. As fluid is introduced to the system and accelerated ...

Development of TiO2 Anatase Thin Films Grown by Pulsed DC Magnetron Reactive Sputtering for Device Applications

ttoinfo@wayne.edu — Tue, 11 May 2010 11:52:44 GMT

WSU researchers have developed a novel procedure for creating Titanium Dioxide (TiO2) thin films using anatase material. Procedure uses TiO2 thin film with single phase a textured material and reproducible with different thickness on amorphous and crystalline substrates. Anatase is attracting much interest for its unique properties and has valuable properties such as high refractive index excellent transmittance in the visible and near-IR frequency and high chemical stability.The anatase material developed at the Wayne State University Smart Sensors and Integrated Microsystems laboratory (SSIM...

SIRT2 Antibody

ttoinfo@wayne.edu — Tue, 11 May 2010 11:52:44 GMT

This technology is a novel rabbit antibody for SIRT2 ( Sirtuin 2) designed to follow human SIRT2 proteins in order to determine their role in gene regulation and apoptosis. Background & Unmet Need:The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Sirtuins have a role in regulation of transcription and apoptosis leading to subs...

Fabrication Methods for Anti-Reflection Surface on Transparent Materials

ttoinfo@wayne.edu — Fri, 07 May 2010 12:26:26 GMT

Development of a fabrication method that uses optical nanostructures as artificial materials that match refractive indices of a wide range of transparent substrates. The resulting surface is optically transparent and exhibits qualities required to see images and text clearly on an electronic display screen in a wide variety of light conditions. Electronic display screens are difficult to see when light reflects off their surface. Glare caused from reflected light reduces the quality of displayed text and images on screens made of glass or plastic. Currently anti-reflection (AR...

A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue

ttoinfo@wayne.edu — Thu, 06 May 2010 08:14:31 GMT

This invention is a new and simple method for the identification of active versus latent matrix metalloprotease enzymes (MMPs) in tissue. Technology Summary MMPs are involved in tumor progression and therefore are targets for anti-cancer drug therapies. However, most drug therapies directed at inhibition of MMPs have failed because there is no reliable biomarker to determine MMP activity in tissue. Using differential specific antibodies targeted to the biomarker of interest, WSU researchers have developed a method to identify whether MMPs are active or in a latent phase. MMP&rs...

Dynamic Bandwidth Allocation Algorithm for Automated Video Surveillance Systems

ttoinfo@wayne.edu — Thu, 29 Apr 2010 11:44:21 GMT

Technology Overview Wayne State researchers have addressed the scalability-cost and power consumption problems of large-scale surveillance systems by developing an optimal bandwidth allocation algorithm, which controls the transfer rates of various video sources. With dynamic bandwidth allocation, the surveillance coverage can be widened as much as possible throughout the site without greatly increasing the required resources and thus the overall system cost. The algorithm considers the potential threat level, placement of video sources, location importance, site map, and rate-accuracy cur...

Volatile Thermally Stable Transition Metal Precursors for Thin Film Growth

ttoinfo@wayne.edu — Fri, 23 Apr 2010 12:54:03 GMT

Wayne State researchers have developed a new class of thermally stable, volatile transition chemical compounds that have desirable properties for the growth of thin films of transition metal-containing materials by atomic layer deposition and chemical vapor deposition.Commercial Applications • Microelectronic devices o Automotive applications o Industrial applications o Consumer electronics o Communications o Computers and periph...

3D Soundscaping

ttoinfo@wayne.edu — Tue, 06 Apr 2010 08:36:16 GMT

Researchers at WSU have developed a 3D Soundscaping technology that enables one to take sound measurements to a new level by locating sound sources, visualize their resultant sound pressure fields in 3D space. In traditional sound sensing applications, sound is measured using microphones and sound pressure levels and spectra are measured at survey locations. It is suitable for all types of sounds including continuous, transient, random, harmonic, impulsive, narrow- and broadband sounds. All this is done by using four microphones, thus significantly cutting the overall costs. Moreover, this...