Latest technologies from Wayne State Universityhttp://wayne.technologypublisher.comBe the first to know about the latest inventions and technologies available from Wayne State Universityen-USFri, 28 Apr 2017 22:21:12 GMTWed, 15 Feb 2017 08:05:57 GMT 2017, Wayne State UniversityToxicological high throughput screens based on prioritized differentiation of mouse viable potency reporter, and viable first differentiated lineage reporter, mouse embryonic stem cells, 15 Feb 2017 08:05:57 GMTttoinfo@wayne.edu treatment with TGFbeta3 to facilitate skin and corneal wound healing in diabetic patients, 10 Feb 2017 13:42:47 GMTttoinfo@wayne.edu and CJ4.3C Rat Conjunctival Epithelial Cell Lines, 30 Jan 2017 10:40:25 GMTttoinfo@wayne.edu Method of Treating B-Cell Cancers, 19 Jan 2017 09:16:24 GMTttoinfo@wayne.edu Artificial Muscles (SAM): Lightweight, soft self-powered actuators to assist mobility, 25 May 2016 11:03:29 GMTttoinfo@wayne.edu Co-Channel Interference with PRK-Based Scheduling for Predictable Link Reliability in Wireless Networked Sensing and Control wireless communication is a basic enabler for networked sensing and control in many cyber-physical systems, yet co-channel interference is a major source of uncertainty in wireless communication. Integrating the protocol model's locality and the physical model's high fidelity, the physical ratio-K (PRK) interference model bridges the gap between the suitability for distributed implementation and the enabled scheduling performance in existing interference models, and it is expected to serve as a foundation for distributed, predictable interference control. To realize the potential of t...Wed, 25 May 2016 09:21:37 GMTttoinfo@wayne.edu IL-1Ra (anakinra) in the form of gel to treat persistent diabetic skin and corneal wounds, 25 May 2016 09:14:21 GMTttoinfo@wayne.edu activity of natural compounds and their synthetic analogue: A potential new antibiotic with potent activity against multiple drug resistant bacterial pathogens, 12 May 2015 06:48:47 GMTttoinfo@wayne.edu Anesthesia Monitor Summary:  WSU researchers have developed a technology to assist anesthesiologists using real-time monitoring, outcome prediction and anesthesia decision support in operating rooms. This smart anesthesia monitoring system allows the physician to look into the near-future and make decisions that are more objective, timely, and accurate. The core of the technology is a novel information processing methodology that uses measured drug rates, physiological signals and real-time data analysis to establish and update individual patient models. Background: General anesthesia is an integral p...Fri, 05 Sep 2014 09:18:02 GMTttoinfo@wayne.edu TUMORS USING PHOSPHOAMIDATE DERIVATIVES OF FAU, 22 Aug 2014 12:42:17 GMTttoinfo@wayne.edu body model of a 10-year-old child for pediatric injury prediction, 11 Oct 2013 08:07:14 GMTttoinfo@wayne.edu Ectodomain of Human EGFR as a Potential Anticancer Agent, 15 Aug 2013 12:32:17 GMTttoinfo@wayne.edu Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors, 14 Aug 2013 10:49:58 GMTttoinfo@wayne.edu DW-MRI analysis methods for detecting motor functions, 14 Aug 2013 09:06:16 GMTttoinfo@wayne.edu Stabilizers for Pressured Metered Dose Inhalers (pMDIs), 14 Aug 2013 09:04:14 GMTttoinfo@wayne.edu on Dielectric (EWOD) Using Graphene, 10 Jun 2013 10:08:30 GMTttoinfo@wayne.edu Biodegradable Polymers for Bone Grafts Summary: A novel polymer nanocomposites has been developed as a potential alternative to autografts and allografts in orthopedic procedures requiring bone grafting. Supercritical CO2 processing of resorbable polymer/nano-clay mixtures results in the formation of porous nanocomposite constructs which exhibit biocompatibility and significant improvements in mechanical properties (2.5-fold increase in compressive strength compared with pure polymer constructs). Improvements in the mechanical properties of the constructs are related to the dispersion of nano-clay within the polymer matr...Mon, 10 Jun 2013 10:07:49 GMTttoinfo@wayne.edu Grapefruit Inhibitor, 10 Jun 2013 10:04:48 GMTttoinfo@wayne.edu caging of nitrile-containing enzyme inhibitors, 29 Apr 2013 10:33:19 GMTttoinfo@wayne.edu Spray Ionization (LSI) Method for Mass Spectrometry Imaging Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI produces ions similar to Electrospray Ionization (ESI) methods without the need for a solvent or voltage. With higher charged ions, LSI extends the mass range (m/z) for high MW analytes which is typically limited in high resolution mass spec instru...Fri, 26 Apr 2013 12:21:02 GMTttoinfo@wayne.edu Method to Stabilize Suspension-Based pMDI HFA Formulations, 23 Apr 2013 12:55:51 GMTttoinfo@wayne.edu Laser Fabrication of Conical Nano-Tips on Semiconductor Thin Films emitter displays (FED) represents the next phase in display technology. A team of researchers at Wayne State University has invented a new process that creates consistently sized and uniformly spaced nano-sized conical tips on semiconductor thin films that may have application in a number of areas including field emitter arrays for flat-panel displays. The tips are up to 1 mm in height with radii on the order of several tens of nanometers. Creating conical tips on semiconductor thin films could provide the reduction in cost necessary to bring flat panel displays in line with CRTs in term...Tue, 23 Apr 2013 11:50:42 GMTttoinfo@wayne.edu action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases, 10 Sep 2012 10:41:45 GMTttoinfo@wayne.edu Nanoparticles for Targeted Treatment of Neuroinflammation Highly effective dendrimer-drug based compositions and methods for treatment have been developed that target neuroinflammation both in the brain and the retina upon intravenous administration. The nanodevices overcome the blood-brain barrier (BBB) and deliver drugs to target cells (activated microglia and astrocytes) producing dramatic therapeutic improvements. Benefits: Many promising pharmaceutical compounds fail to reach target tissue or fail to remain in the target area long enough to work. The drug-dendrimer nanoparticles invented at WSU allow the drug to be carried to target a...Thu, 02 Aug 2012 13:46:34 GMTttoinfo@wayne.edu Generation MRI Contrast Imaging Agent, 02 Aug 2012 12:40:28 GMTttoinfo@wayne.edu<![CDATA[Intelligent Autonomous Camera Control for Robotics with Medical, Military, & Space Applications]]>, during robotic surgery the surgeon must interrupt the operation and shift controls to move the camera arm of the robot, causing a distraction for the surgeon.  Researchers from Wayne State University’s Electrical and Computer Engineering Department and the School of Medicine have jointly developed a new method for camera movement based on internally tracking (via kinematics of the robot) the locations of the end-effectors and automatically moving the camera arm to follow and zoom into the region where the surgeon is working.  The system can be configured to ensure that the tracked e...Tue, 24 Jul 2012 13:10:59 GMTttoinfo@wayne.edu of 1-D MnO2 Nanowire and 2-D Graphene to 3-D Composites and their Applications in High-Energy, High-Power and Low-Cost Aqueous Supercapacitors, 18 Jul 2012 13:58:07 GMTttoinfo@wayne.edu Cycle-by-Cycle NOx Measuring Technique in Spark Ignited Engines, 24 Apr 2012 07:07:53 GMTttoinfo@wayne.edu Messaging System, 19 Dec 2011 10:52:01 GMTttoinfo@wayne.edu Peripheral Detection Test-I (EPDT-I) Enhanced Peripheral Detection Test-II (EPDT-II), 15 Dec 2011 11:49:04 GMTttoinfo@wayne.edu Layer Deposition of Transition Metal Thin Films Wayne State University researchers have circumvented precursor reactivity problems by developing a three-step deposition scheme that entails a transition metal precursor, an organic acid, and a reducing agent. This novel process can produce high purity, low resistivity copper films at 100 °C, which is a significant breakthrough in transition metal ALD processes. Microelectronics device dimensions are scheduled to reach 22 nm by 2012, and existing deposition processes will soon not be able to provide the required level of thickness control and conformality, especially in high aspect ratio feat...Wed, 23 Nov 2011 07:43:34 GMTttoinfo@wayne.edu Optofluidic Tweezers (MOT), 23 Nov 2011 07:43:33 GMTttoinfo@wayne.edu Flexible Biocompatible Graphene Sensor for Point-of-care Diagnosis, 23 Nov 2011 07:43:32 GMTttoinfo@wayne.edu Zn-base Catalysts for Simultaneous Transesterification and Esterification, 23 Nov 2011 07:43:32 GMTttoinfo@wayne.edu based support matrix to anchor bifunctional catalyst for Lithium-Air batteries, 22 Nov 2011 10:30:12 GMTttoinfo@wayne.edu Silicon nanoparticle (SiNP)/Graphene composite anode for high performance Lithium ion battery (LIB), 07 Nov 2011 10:04:39 GMTttoinfo@wayne.edu array formation process and its use for high-throughput loading and crystallization screening and other lab-on-the-chip applications, 07 Nov 2011 10:04:38 GMTttoinfo@wayne.edu, Process, and Method for Producing Hybrid Green Cements and Their Concrete Products, 07 Nov 2011 10:04:37 GMTttoinfo@wayne.edu Ion Sensing and Gas sampling in Combustion Engine Cylinders and Other Combustion Systems, 19 Jul 2011 08:13:21 GMTttoinfo@wayne.edu Cycle-by-Cycle Soot Measuring Technique in Diesel Engines there is no device or technology to allow for onboard soot measurement in diesel engine vehicles. Wayne State University researchers have developed a technique which utilizes the ion current signal produced from an ion current sensor installed in the combustion chamber of each cylinder to determine the quantity of soot present in the cylinder at the end of the combustion process.  During each cycle, the cylinder’s exhaust valve opens and its contribution in the total soot emitted in the exhaust of multi-cylinder diesel engines is measured.Additionally, the input signal from each cyli...Tue, 19 Jul 2011 08:13:20 GMTttoinfo@wayne.edu Operation of Electronically Controlled Diesel Engines on a Multitude of Fuels Using Ion Current and Other Combustion Sensors, 18 Jul 2011 10:53:12 GMTttoinfo@wayne.edu Fusion with Neuregulin Heparin-Targeting Domain to Block Neuregulin Signaling, 16 May 2011 14:00:13 GMTttoinfo@wayne.edu Antimicrobial, 03 May 2011 06:51:46 GMTttoinfo@wayne.edu Row Transition Metal Diazadiene Film Growth Precursors, 02 May 2011 10:48:18 GMTttoinfo@wayne.edu metamaterial with mass and flexible stem array, 02 May 2011 10:42:22 GMTttoinfo@wayne.edu of a High Strength High Toughness (HSHT) Bainitic Steel invention is a unique composition of steel when subjected to a non-conventional austempering process results in the following physical property advantages over high strength low alloy (HSLA) steel:- Twice the strength- Almost three times the fracture toughnessAustempering is a process typically used to produce specialty cast iron products but is not employed in the processing of steel. The austempering process that is unique to this invention alters both the temperature and time profiles of iron austempering to increase nucleation sites resulting in a finer grain microstructure th...Fri, 29 Apr 2011 10:56:29 GMTttoinfo@wayne.edu Reduction Helmet, 10 Mar 2011 07:16:45 GMTttoinfo@wayne.edu Energy Harvesting Device Based on Air-Spaced Piezoelectric Cantilevers, 05 Oct 2010 12:25:02 GMTttoinfo@wayne.edu and Control System for Under Actuated Marine Surface Vessels, 21 Sep 2010 06:58:36 GMTttoinfo@wayne.edu Homogeneous and Heterogeneous Catalytic Transesterification Process for Biodiesel Production researchers developed a combined heterogeneous and homogeneous catalyst that reduces overall production costs, expands feedstock options, and enables large volume production in a continuous process as compared to traditional homogeneous biodiesel catalysts. This unique catalytic transesterification process works better with ethanol compared to methanol can be used in continuous or batch biodiesel production processes and has advantages over existing homogeneous catalyst processes including:- Eliminates use of caustic catalysts that generate significant soap formation and environmental iss...Tue, 17 Aug 2010 12:31:18 GMTttoinfo@wayne.edu of Peritoneal Healing and Adhesion Development, 15 Jul 2010 11:20:03 GMTttoinfo@wayne.edu AKT Inhibitors for the Treatment of Protein Misfolding and Protein Trafficking Diseases, 22 Jun 2010 06:18:53 GMTttoinfo@wayne.edu Efficient Reagent that Transfers Protein into the Living Mammalian Cells This invention is a new protein transduction method for efficient delivery of exogenous proteins into mammalian cells. In contrast to known protein transduction methods, this new approach has the capability of targeting transduced proteins to different cellular compartments, as well as protecting the proteins from degradation by cellular proteases. The reagent for delivery of the proteins is composed of cationic agents, lipids and enhancer in a carrier. The Approach uses bacteria to produce recombinant proteins that are then modified with the reagent and delivered into mammalian cells...Tue, 22 Jun 2010 06:18:47 GMTttoinfo@wayne.edu of Matrix Metalloproteinases Wayne State University researchers and academic collaborators have prepared the first reported mechanism-based inhibitors for matrix metalloproteinases (MMPs). One of the novel compounds (SB-3CT) shows selectivity for the gelatinases (two members of the MMP family), which have been implicated in various pathological conditions including, but not limited, to the process of tumor metastasis and angiogenesis, cardiovascular diseases and neurological conditions. In vivo results from WSU and academic collaborators have shown promise in cancer therapy (in T-cell lymphoma and prostate cancer...Tue, 22 Jun 2010 06:18:32 GMTttoinfo@wayne.edu Injector to Work as an Ionization Sensor and as an Injection Signal Detector in Electronically Controlled Fuel Injection Systems in Diesel and Direct Injection Gasoline Engines, 04 Jun 2010 07:01:31 GMTttoinfo@wayne.edu Representing Genus-Specific Chlamydial Antigens for Vaccine Peptide Vaccines for Chlamydia to be Delivered Orally or by Other Mucosal Routes, 18 May 2010 06:29:39 GMTttoinfo@wayne.edu Flagellin to Prevent and to Treat Inflammation Associated Gram Negative Bacterial Infection Description The existence of multipotent stem cells within the adult brain has been debated for some time. While the identity of this cell has been unknown it is clear that stem cells reside in specialized tissue (subventricular zone and subgranular zone) and that local microenvironments regulate their differentiation and self-renewal. WSU researchers have identified capillary pericytes as possessing pluripotent stem cell capability. One set of culture conditions result in the differentiation of pericytes along a mesenchymal lineage forming bone muscle cells adipocytes chondroc...Tue, 18 May 2010 06:29:37 GMTttoinfo@wayne.edu to Produce Immunostimulatory Proteins and Tether Them to the Membrane of Enveloped Virus Vaccines Description Wayne State University researchers have developed a method to produce immunostimulatory cytokine proteins and tether them to the membrane of enveloped virus vaccines produced in cell culture. In vivo results to date indicate that this technology improves vaccine efficacy. Cytokines as soluble proteins have proven to be effective as adjuvants for experimental viral vaccines since they boost immune responses induce T cytotoxic cells and shift Th2 to Th1 responses. However there are limitations in formulations currently used to coadminister soluble cytokines: 1.It is d...Tue, 18 May 2010 06:29:37 GMTttoinfo@wayne.edu B4, 18 May 2010 06:29:36 GMTttoinfo@wayne.edu Prostheses Based Upon Fiber-Optic Uncaging of Neurotransmitter Substances Description A fiber optic cable may also be used to deliver light. The drug delivery system selectively delivers drugs to various types of neurological cells. In operation a solution of photoactivatable neuro-active drug is delivered to a pre-selected area in vivo and photoactivated in the solution at the pre-selected area to stimulate neurological tissue. The neuro-active drug may be either an agonist or an antagonist of neuronal activity. File Number: 00-496 Tue, 18 May 2010 06:29:34 GMTttoinfo@wayne.edu Improvements in Fahr Disease, 18 May 2010 06:29:33 GMTttoinfo@wayne.edu Bases of Conjugated Styryl Ketones Description Human infectious diseases caused by fungi have increased markedly during the past 10 years due mainly to advances in medical care that involve prolonged immune suppression increased use of cytotoxic drugs in cancer chemotherapy and the advent of AIDS. As a result organisms such as Candida albicans have become opportunistic pathogens capable of causing severe systemic infection. Consequently as high as 10% of hospital-acquired bloodstream infections are currently caused by fungi yet there have been few major improvements in the treatment and management of fungal in...Tue, 18 May 2010 06:29:33 GMTttoinfo@wayne.edu of a Prostate Carcinoma Bone Tumor Model in Mice, 18 May 2010 06:29:32 GMTttoinfo@wayne.edu of a Metastatic Prostate Carcinoma Tumor Model in Mice, 18 May 2010 06:29:32 GMTttoinfo@wayne.edu of a New Renal Cell Carcinoma Cell Line and a New Experimental Renal Tumor Model, 18 May 2010 06:29:31 GMTttoinfo@wayne.edu Mammalian Putative Phosphatidylinositol-4-Phosphate-5-Kinase, 18 May 2010 06:29:30 GMTttoinfo@wayne.edu Prenyl Transferase Inhibitors, 18 May 2010 06:29:30 GMTttoinfo@wayne.edu For Treating and/or Imaging Breast Cancer Using Radioactive Iodine, 18 May 2010 06:29:28 GMTttoinfo@wayne.edu Antisiphon Shunt System (P-A-S-S), 18 May 2010 06:29:28 GMTttoinfo@wayne.edu Molecule Encoding the B3 Adrenegic Receptor, 18 May 2010 06:29:27 GMTttoinfo@wayne.edu Assay for Demethylation Description WSU researchers have developed a fluorescence-based assay for the dealkylation activity of the non-heme iron (II) a-ketoglutarate-dependent dioxygenase family of enzymes. This assay uses formaldehyde dehydrogenase to convert formaldehyde to formic acid and monitors the creation of an NADH analog using fluorescence. The technology is a great improvement over the existing assays for DNA demethylation in that is continuous rapid and does not require radioactively labeled material. Additionally this assay may also be utilized to study the demethylation of histones. This...Thu, 13 May 2010 12:29:49 GMTttoinfo@wayne.edu Technology of Production of Properly Folded Protein invention is a new protein transduction method for efficient delivery of exogenous proteins into mammalian cells. In contrast to known protein transduction methods, this new approach has the capability of targeting transduced proteins to different cellular compartments, as well as protecting the proteins from degradation by cellular proteases. The reagent for delivery of the proteins is composed of cationic agents, lipids and enhancer in a carrier. The Approach uses bacteria to produce recombinant proteins that are then modified with the reagent and delivered into mammalian cells....Thu, 13 May 2010 12:29:46 GMTttoinfo@wayne.edu Biosensor Based on Parylene Cantilevers A Wayne State University researcher has developed a novel biosensor for DNA and protein microarray applications as well as lab-on-a-chip assays. The biosensor is composed of a micro-scale cantilever made of a polymer material with a modulus of elasticity significantly less than cantilever-based biosensors utilizing silicon nitride. Biosensors based on microfabricated cantilevers have attracted many interests in recent years. These sensors utilize the fact that when biochemical molecules (DNA antibody etc.) selectively bind to one side of the cantilever the surface stress induced will...Thu, 13 May 2010 12:29:43 GMTttoinfo@wayne.edu (Non-Magnetic) Structural Steel State University research has yielded both a novel composition and a lower cost processing technique for the creation of austenitic non-magnetic structural steel. This steel has advantages that include a high work hardening rate, good corrosion resistance, combination of strength and ductility and good creep resistance. Use of this steel in energy generation devices will reduce magnetic permeability and thus reduce power loss. Commercial Applications • Naval structures and ship construction• Petrochemical and food processing industries• Energy generation devices Competitive Adv...Thu, 13 May 2010 12:29:42 GMTttoinfo@wayne.edu Magnetic Field Anti-Inflammatory Device Description Wayne State University and University of Michigan researchers have developed methods and devices which employ the use of electrical and magnetic fields to mitigate cellular responses to inflammation. Via the application of certain electric or magnetic fields changes and conversions of cell types are achieved along with modification of the physiological function of these cells thereby yielding a therapeutic effect. This approach affects neutrophils macrophages lymphocytes platelets and retinal cells and thus has the potential to provide therapeutic benefit to many di...Thu, 13 May 2010 12:29:41 GMTttoinfo@wayne.edu of Arsenic in S. Cerevisiae Description WSU faculty developed an innovative biological technology that has promise to cost-effectively remove arsenic from drinking water. The technology employs the use of a genetically engineered strain of yeast with the ability to hyper-accumulate arsenic without releasing the arsenic back into the environment. The yeast is being optimized for arsenic accumulation the next step will be the development of bioreactors to remove arsenic from natural groundwater supplies. While federal legislation is still in flux regarding the implementation date for new maximum contaminant...Thu, 13 May 2010 12:29:40 GMTttoinfo@wayne.edu Temperature Range MIS Hydrogen Sensors, 13 May 2010 12:29:39 GMTttoinfo@wayne.edu High Efficiency Booster for Automotive and Other Applications WSU faculty developed a high efficiency booster useful in devices where the gas turbine is the primary source of power and in hybrid automotive engines. Boosters are currently used in hybrid automotive engines or in stationary plants for the purpose of increasing the power output of the gas turbine. It is generally accepted that a good power producing system has reasonably high thermal efficiency consistent with economical environmental and other constraints. However current technology does not meet these goals since it provides only limited power output and thus decreased fuel e...Thu, 13 May 2010 12:29:38 GMTttoinfo@wayne.edu Resonance Force Microscopy for Molecular Imaging Description Magnetic Resonance Force Microscopy (MRFM) is an emerging technology that combines the strengths of magnetic resonance and force microscopy to achieve high resolution three-dimensional sub-surface imaging of a test substance. WSU researchers have adapted and refined MRFM to study biological systems such as isolated cells sub-cellular organelles and other sub-cellular structures or cellular receptors and proteins at resolutions ranging from 1 micron to 1 angstrom. MRFM has the potential to significantly impact biomedical research and biotechnology including the poten...Thu, 13 May 2010 12:29:37 GMTttoinfo@wayne.edu Gain Infrared Collector and Data Node infrared collector employs a concentrator formed of a plurality of spatially related gradient-indexed (GRIN) lenses and a photo detector interconnected by optical fibers. Since the GRIN lenses are arranged on a hemispherical shell the concentrator is relatively insensitive to the direction of the incoming infrared radiation. Optical fibers are used to connect the GRIN lenses to a photo detector where assembly is simplified. Commercial Applications • Infrared data networks Competitive Advantages • Infrared detector in the collector has a size that is significantly smaller than tho...Thu, 13 May 2010 12:29:37 GMTttoinfo@wayne.edu active ATP-Analogs for tagging phosphoproteins A novel Photo Cross Linking Assay (PCLA) for targeting protein phosphorylation Protein phosphorylation catalyzed by kinases and phosphatases act at critical control points that regulates many cellular processes. This central role makes them an attractive target for identifying largely untapped and important biomarkers for disease diagnostics. Understanding which proteins interact in a given pathway is an important step to aid in the discovery of therapeutics. Despite the development of a variety of innovative new technologies, dissecting the phosphorylation cascades that regulates cellular ac...Tue, 11 May 2010 11:52:48 GMTttoinfo@wayne.edu Piezoresistive Accelerometer Based on Decoupled Piezoresistors piezoresistive accelerometer that has advantages over traditional piezoresistive accelerometers in both the sensitivity and minimum detectable acceleration.Wayne State University researchers have developed an ultra-sensitive piezoresistive accelerometer that has advantages over traditional piezoresistive accelerometers in both the sensitivity and minimum detectable acceleration. Traditional piezoresistive accelerometers face challenges in applications where high bandwidth and high resolution are required simultaneously such as respiratory sound monitoring. Commercial Applicatio...Tue, 11 May 2010 11:52:47 GMTttoinfo@wayne.edu Particle Concentration and Separator at the Wayne State University Smart Sensors and Integrated Microsystems (SSIM) laboratory have developed a micro-scale concentrator and separator applicable to several microfluidic applications. Initially the device was developed to concentrate and separate bacteria from other impurities to test water quality however the micro separator could have much broader applicability. The device and its fabrication method are unique. The device is composed of a large array of identical flow units arranged in a stagger and cascade fashion. As fluid is introduced to the system and accelerated ...Tue, 11 May 2010 11:52:45 GMTttoinfo@wayne.edu of TiO2 Anatase Thin Films Grown by Pulsed DC Magnetron Reactive Sputtering for Device Applications researchers have developed a novel procedure for creating Titanium Dioxide (TiO2) thin films using anatase material. Procedure uses TiO2 thin film with single phase a textured material and reproducible with different thickness on amorphous and crystalline substrates. Anatase is attracting much interest for its unique properties and has valuable properties such as high refractive index excellent transmittance in the visible and near-IR frequency and high chemical stability.The anatase material developed at the Wayne State University Smart Sensors and Integrated Microsystems laboratory (SSIM...Tue, 11 May 2010 11:52:44 GMTttoinfo@wayne.edu Cleaning Transparent Material Structure and its Fabrication Methods A Wayne State University Professor has developed a material with unique self-cleaning properties that may serve a number of applications from self-cleaning automobile windshields, eyeglasses and optics to laboratory glassware, mirrors and sensors. Highly water-repellant materials (also known as Super Hydrophobic Surfaces) have been created and employed in a number of applications. However their widespread use to date has been hampered by the fact that such materials are generally non-transparent. As such these materials have not been suitable for windows windshields, camera lenses and...Tue, 11 May 2010 11:52:44 GMTttoinfo@wayne.edu Antibody, 11 May 2010 11:52:44 GMTttoinfo@wayne.edu Method of Making 3-Dimensional Neural Probes, 07 May 2010 12:26:29 GMTttoinfo@wayne.edu of Natural and Synthetic Antioxidants on the Oxidative Stability of Biodiesel at WSU’s National Biofuels Energy Laboratory have identified antioxidant additives for biodiesel fuel made from a variety of feedstock that provide advantages to current technologies. A significant problem associated with the commercial acceptance of biodiesel fuel is poor oxidative stability. The presence of high levels of unsaturated fatty acid methyl esters (FAME) makes biodiesel very susceptible to oxidation as compared to petroleum diesel. Oxidative processes can lead to the formation of insolubles which can potentially plug fuel filters and injection systems. The increased ac...Fri, 07 May 2010 12:26:28 GMTttoinfo@wayne.edu Vehicle Roof Interior Design Concepts for Occupant Neck Protection During Rollover Crashes at the Bioengineering Center at WSU have developed an interior roof design that reduces the coefficient of friction (COF) between the head and the roof or reduces the COF between the padding and its supporting structure. Rollover crashes are the most hazardous crashes to the human cervical spine. It has been reported that the neck is the third most commonly injured body region during rollovers following the head and thorax and often leads to permanent disabilities. Currently vehicle interior roofs or headliners are not designed to reduce the risk of neck injuries in rollover accide...Fri, 07 May 2010 12:26:27 GMTttoinfo@wayne.edu Methods for Anti-Reflection Surface on Transparent Materials of a fabrication method that uses optical nanostructures as artificial materials that match refractive indices of a wide range of transparent substrates. The resulting surface is optically transparent and exhibits qualities required to see images and text clearly on an electronic display screen in a wide variety of light conditions. Electronic display screens are difficult to see when light reflects off their surface. Glare caused from reflected light reduces the quality of displayed text and images on screens made of glass or plastic. Currently anti-reflection (AR) screen...Fri, 07 May 2010 12:26:26 GMTttoinfo@wayne.edu Pericytes are Adult Pluripotential Stem Cells Description The existence of multipotent stem cells within the adult brain has been debated for some time. While the identity of this cell has been unknown it is clear that stem cells reside in specialized tissue (subventricular zone and subgranular zone) and that local microenvironments regulate their differentiation and self-renewal. WSU researchers have identified capillary pericytes as possessing pluripotent stem cell capability. One set of culture conditions result in the differentiation of pericytes along a mesenchymal lineage forming bone muscle cells adipocytes chondro...Fri, 07 May 2010 12:26:25 GMTttoinfo@wayne.edu Drug Delivery Devices (Nanoparticles) that Demonstrate High Encapsulation Efficiency and Sustained Release of Water-Soluble Drugs and their Preparation researchers have developed a nanoparticle formulation for the encapsulation of hydrophilic drugs with high efficiency. Encapsulation efficiency close to 100% has been achieved. Further these nanoparticles demonstrate sustained release of hydrophilic drugs over a period of weeks (~60-80% of encapsulated drug released over a period of 4 weeks). As a comparison published studies that investigate the use of other state of the art nanoparticles withwater-soluble drugs report sustained release only over a period of few hours. Additionally due to high surface area afforded by nanoparticle...Fri, 07 May 2010 12:26:25 GMTttoinfo@wayne.edu to a Novel Cell Cycle and Apoptosis Regulatory Protein (CARP) -1 Retinoic acid and its synthetic derivatives participate in many biological processes including development cellular proliferation and differentiation. Retinoids mediate their actions by binding to the nuclear retinoic acid receptors and retinoid X receptors. Wayne State University researchers found that retinoid induced cell cycle arrest and apoptosis in several human breast carcinoma cell lines is independent of tumor suppressor p53 and estrogen receptor status via an undefined mechanism. This led to the identification of a novel cDNA which encodes a 130 Kda protein referred to as CA...Fri, 07 May 2010 12:26:25 GMTttoinfo@wayne.edu of Molecular Targets of Cancer and Aging Using Cellular Immortalization-Specific Gene-Expression, 07 May 2010 12:26:24 GMTttoinfo@wayne.edu In Vitro Model System for Studying Development of Human Preneoplastic Breast Disease State University researchers have developed a novel model/assay system that recapitulates in vitro the in vivo processes that lead to breast cancer development and progression from preneoplastic tissue. This model is the first that demonstrates in vitro the de novo development and neoplastic conversion of functional alveolar units. Advantages of this model include the fact that it requires only about 7 days for alveolar morphogenesis to occur compared to 8-10 weeks in vivo. This permits the use of this system for relatively high throughput drug screening. In this model preneoplas...Fri, 07 May 2010 12:26:23 GMTttoinfo@wayne.edu for Chicken Interleukin 15... Detailed Description WSU researchers have cloned and patented chicken IL-2 and related avian lymphokines for use as avian vaccine adjuvants. The inventors have shown experimentally that chicken IL-2 can enhance vaccine effectiveness in chickens. Future research to further enable this technology will likely include optimization of delivery methods. IL-2 has a short serum half-life and for maximum efficacy must be attached to or closely associated with the vaccine antigen(s). Various studies have utilized chicken IL-2 fused to antigen expressed by viral vaccine vectors and expressed in D...Fri, 07 May 2010 12:26:22 GMTttoinfo@wayne.edu Immunotherapies for Cancer, 06 May 2010 08:14:36 GMTttoinfo@wayne.edu Targeting by Small Molecule Therapeutics for a Proton-Coupled Folate Transporter (PCFT), 06 May 2010 08:14:33 GMTttoinfo@wayne.edu Single Nucleotide Polymorphism rs4644 Predicts Human Cancer Risk Associated with Racial Disparity, 06 May 2010 08:14:32 GMTttoinfo@wayne.edu Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue, 06 May 2010 08:14:31 GMTttoinfo@wayne.edu pDMI Inhaler Formulations, 06 May 2010 08:14:31 GMTttoinfo@wayne.edu detection with surface selective vibrational spectroscopy, 06 May 2010 08:14:30 GMTttoinfo@wayne.edu Technology of Studying Protein Structure/Folding Functions in Living Mammalian Cells This invention is a new protein transduction method for efficient delivery of exogenous proteins into mammalian cells. In contrast to known protein transduction methods, this new approach has the capability of targeting transduced proteins to different cellular compartments, as well as protecting the proteins from degradation by cellular proteases. The reagent for delivery of the proteins is composed of cationic agents, lipids and enhancer in a carrier. The Approach uses bacteria to produce recombinant proteins that are then modified with the reagent and delivered into mammalian cells...Thu, 06 May 2010 08:14:29 GMTttoinfo@wayne.edu Preservation Device WSU inventors have designed devices that enable small pieces of human tissue or stool to be rapidly immersed and preserved at room temperature in toxic preservatives without exposing the end user to the toxicants. Samples contained in the device can be safely stored or used for biochemical, molecular, and structural analysis. The device design makes them very easy and safe to operate. They can be used at home, hospital, or out in the field for forensic sample collection without the need for refrigeration. Furthermore, the provider/manufacture of the device has the flexibility of using...Thu, 06 May 2010 08:14:29 GMTttoinfo@wayne.edu Receptor Targeted Therapeutics for Cancer researchers at WSU and Duquesne University have developed a series of novel folate analogs that show selective toxicity toward tumor cells expressing high levels of the surface protein folate receptor. Typically, normal cells express low levels of folate receptors or such receptors exhibit apical localization and are not exposed to the blood. In additional to the folate receptor selectivity, these compounds are potent inhibitors of glycinamide transformylase (GARTFase), a purine nucleotide biosynthetic enzyme. This is the first description of a compound exhibiting both ch...Thu, 06 May 2010 08:14:29 GMTttoinfo@wayne.edu Tandem Mass Spectrometry: Reduction to Practice Currently, tandem mass spectrometry is typically performed by selecting a single mass peak in a time of flight or quadrupole mass spectrometer, which is then fragmented through collision, after which the products are mass-selected in a quadrupole or similar secondary mass spectrometer. A Wayne State University researcher has developed an alternative approach which records the full 2-D tandem mass spectrum at once, revealing the correlations between the mass speaks formed in the first and second step. Velocity map imaging is coupled with pulsed electric deflection in a reflectron confi...Thu, 06 May 2010 08:14:28 GMTttoinfo@wayne.edu Dual and Triple Acting CNS Compounds with Potential as Antidepressants, Medications for Attention Deficit Disorders and other Related Neuro-disorders Wayne State University researchers have identified compounds with a unique molecular template exhibiting reuptake inhibition activity for both at the norepinephrine and serotonin transporters in the CNS. In addition, some of these molecules also exhibit triple reuptake activity for the dopamine, serotonin and norepinephrine transporters. These compounds have shown impressive dual and triple uptake inhibition activity in vitro, have exhibited in vivo antidepressant activity in forced swimming test model in both mice and rats. Lead compounds will be tested in additional in vivo models, ...Thu, 06 May 2010 08:14:25 GMTttoinfo@wayne.edu Aminoglycosides State University researchers have synthesized a series of novel aminoglycoside antibiotics that have shown enhanced antibacterial activity, low susceptibility to existing resistance mechanisms and low toxicity when compared to currently marketed aminoglycosides. Aminoglycoside antibiotics have been used against a wide variety of bacterial infections caused by Gram-positive and Gram-negative bacteria. The activity of the aminoglycosides is due to binding to bacterial RNA. Currently marketed aminoglycoside antibiotics are indicated for treatment of serious bacterial infections, but...Thu, 06 May 2010 08:14:24 GMTttoinfo@wayne.edu Compounds Specific for the Monoamine Transporter Systems dopamine transporter (DAT) plays an important role in pathophysiological processes in the central nervous system. In cocaine addiction, binding of cocaine to the DAT and consequent blockage of dopamine uptake appears to be related to the reinforcing properties of the drug. Also associated with the transport function is concentration of neurotoxic chemicals in dopaminergic neurons which is implicated in Parkinson’s disease. Potent, yet selective ligands for the DAT have potential for in vivo monitoring of primary targets of cocaine in the brain, for the characterization of cocaine b...Thu, 06 May 2010 08:14:24 GMTttoinfo@wayne.edu Hybrid Series of Compound Derived from 2-Aminotetralin and Piperazine Based Derivatives: Characterization for D1, D2, D3, D4 and other Serotonin Receptor Subtypes Binding A series of compounds derived from 2-aminotetralin and piperazine fragments have been synthesized, which exhibit high CNS activity in vivo and in vitro. Some of the selected lead compounds have exhibited potent in vivo activity in a Parkinson’s disease animal model with long extended duration of action. In particular, these compounds show high D3 receptor affinity and/or high D3/D2 selectivity. In addition to the potential therapeutic treatment of Parkinson’s disease and depression, these novel compounds have possible application in the treatment of a number of other neurological diso...Thu, 06 May 2010 08:14:23 GMTttoinfo@wayne.edu Bandwidth Allocation Algorithm for Automated Video Surveillance Systems Overview Wayne State researchers have addressed the scalability-cost and power consumption problems of large-scale surveillance systems by developing an optimal bandwidth allocation algorithm, which controls the transfer rates of various video sources. With dynamic bandwidth allocation, the surveillance coverage can be widened as much as possible throughout the site without greatly increasing the required resources and thus the overall system cost. The algorithm considers the potential threat level, placement of video sources, location importance, site map, and rate-accurac...Thu, 29 Apr 2010 11:44:21 GMTttoinfo@wayne.edu Thermally Stable Transition Metal Precursors for Thin Film Growth, 23 Apr 2010 12:54:03 GMTttoinfo@wayne.edu Optical Polarizer for Silicon-on-Insulator Waveguides optics based on silicon-on-insulator platforms are developing extremely fast due to technological compatibility with complementary metal-oxide-semiconductor (CMOS) fabrication process widely accepted in microelectronics.  Wayne State researchers have developed a technology which generates an integrated optical polarizer for high index contrast SOl waveguides, which operates through resonant coupling of TM-polarized guided mode to a high-index mode supported by a nanoscale metal dielectric multilayer, such as gap plasmon-polariton.  This new technology of several nano-scale metal-die...Fri, 23 Apr 2010 12:54:02 GMTttoinfo@wayne.edu Soundscaping Researchers at WSU have developed a 3D Soundscaping technology that enables one to take sound measurements to a new level by locating sound sources, visualize their resultant sound pressure fields in 3D space. In traditional sound sensing applications, sound is measured using microphones and sound pressure levels and spectra are measured at survey locations. It is suitable for all types of sounds including continuous, transient, random, harmonic, impulsive, narrow- and broadband sounds. All this is done by using four microphones, thus significantly cutting the overall costs. Moreover, this n...Tue, 06 Apr 2010 08:36:16 GMTttoinfo@wayne.edu Angular Acceleration Reduction Helmet State researchers have designed a new device to reduce the head angular acceleration of the helmet wearer during blunt impact. This technology introduces a helmet shell design which rotates with respect to head by the insertion of a thin layer of elastically or plastically yielding material between the outer and inner shells, depending on the type of helmet.  Current helmet technology utilizes a double shell technology with the outer shell rotating in respect to the inner shell. Due to the restriction of rotation about only one axis and the lack of control of stopping the outer shell of ...Fri, 19 Mar 2010 07:22:16 GMTttoinfo@wayne.edu