Search Results - "Life Science" and "Diagnostic"

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ERK-Mediated Grb7 Phosphorylation: A Biomarker and Potential Therapeutic Target in Her2/Grb7 Amplified Cancers

This invention is a new bio-marker for breast and other cancers that have Her2 and Grb7 gene amplifications, thus providing a therapeutic intervention in Her2/Grb7 amplified cancers.Background40% of breast cancers, as well as several other cancer types, display increased activation of tyrosine kinases from the ErbB family, with Her2 found amplified...

Published: 8/3/2017 | Inventor(s): Guri Tzivion, Deborah Leicht, Alexander Kaplun, Stephen Ethier

Keywords(s): Biomarker, Biotechnology, Cancer, Cancer Therapies, Therapeutics

Category(s): Diagnostic, Life Science, Oncology

Method For Treating and/or Imaging Breast Cancer Using Radioactive Iodine

This invention involves treating a breast cancer patient by the administration of a radioisotope of iodine in a dosage of between 5 and 50 milliCuries over the course of a day. The therapeutic composition is designed for mammary tissue uptake and includes an inorganic radioactive iodide salt (e.g., alkali metal, alkali earth or transition met...

Published: 5/18/2010 | Inventor(s): James Rillema

Keywords(s): Anti-cancer, Breast Cancer, Cancer Therapies, Imaging, Therapeutics

Category(s): Therapeutics, Life Science, Oncology, Receptors/targets, Diagnostic, Imaging

Novel Biosensor Based on Parylene Cantilevers

A Wayne State University researcher has developed a novel biosensor for DNA and protein microarray applications as well as lab-on-a-chip assays. The biosensor is composed of a micro-scale cantilever made of a polymer material with a modulus of elasticity significantly less than cantilever-based biosensors utilizing silicon nitride. Biosensors base...

Published: 5/13/2010 | Inventor(s): Yong Xu

Keywords(s): Device

Category(s): Life Science, Physical Sciences, Diagnostic, Other, Sensors

SIRT2 Antibody

This technology is a novel rabbit antibody for SIRT2 ( Sirtuin 2) designed to follow human SIRT2 proteins in order to determine their role in gene regulation and apoptosis.Background & Unmet Need:The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and supp...

Published: 5/11/2010 | Inventor(s): Michael Tainsky, Sylvia Dryden

Keywords(s): Compound, Protein

Category(s): Diagnostic, Antibodies, Life Science, Research tools

Antibodies to a Novel Cell Cycle and Apoptosis Regulatory Protein (CARP) -1

Wayne State University researchers have identified a novel cDNA which encodes a pro-apoptotic protein called CARP-1 (Cell Cycle and Apoptosis Regulatory Protein-1), which is expressed in many cancer cell types including breast and colon carcinoma cells. This novel cDNA can be used as a diagnostic and prognostic tool for many types of cancer. Bac...

Published: 5/7/2010 | Inventor(s): Arun Rishi, Joseph Fontana

Keywords(s): Antibody, Breast Cancer, Cancer, Drug Target

Category(s): Diagnostic, Life Science, Research tools, Antibodies

Derivation of Molecular Targets of Cancer and Aging Using Cellular Immortalization-Specific Gene-Expression

This technology identifies molecular targets required for immortalization, which is a trait spontaneously acquired by cancer cells. These targets may provide a potential means to intervene in the process of aging or cancer development. Background & Unmet Need: Recent efforts to develop improved methods for breast cancer detection, staging, an...

Published: 5/7/2010 | Inventor(s): Sorin Draghici, Olga Studitskaia, Michael Tainsky

Keywords(s): Cancer, Drug Target

Category(s): Diagnostic, Life Science, Oncology