Search Results - "Life Science" and "Diseases"




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Antibacterial activity of natural compounds and their synthetic analogue: A potential new antibiotic with potent activity against multiple drug resistant bacterial pathogens
Our researchers have developed novel compounds that are potential antibiotics useful for treatment against the deadly bacteria MRSA (methicillin-resistant Staphylococcus aureus), VRE (vancomycin-resistant Enterococcus faecium), and several other well-known common infectious agents.Background & Unmet Need:Before antibiotics became available in t...
Published: 5/12/2015   |   Inventor(s): Fazlul Sarkar, Hossein Salimnia, Subhash Padhye, Bernhard Biersack
Keywords(s): Analog or Analogue, Antibiotics, Anti-infective, Anti-microbial, Disease
Category(s): Biologicals, Diseases, Infectious disease, Life Science, Therapeutics
Modified Ectodomain of Human EGFR as a Potential Anticancer Agent
Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion of the EGFR...
Published: 8/15/2013   |   Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu
Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics
Category(s): Life Science, Biologicals, Diseases, Oncology
Repurposing AKT Inhibitors for the Treatment of Protein Misfolding and Protein Trafficking Diseases
WSU researchers have generated a reagent to understand the degenerative processes occurring in Pelizaeus‑Merzbacher disease (PMD) and to study the intracellular signaling that occurs because of these diseased processes. They have deduced that the use of AKT inhibitors may reduce disease severity in patients with a wide range of degenerative ...
Published: 6/22/2010   |   Inventor(s): Alexander Gow, Cherie Southwood
Keywords(s): Alzheimer's Disease, Anti-cancer, Neuro-disorders, Parkinson's
Category(s): Life Science, Neurological disorders, Therapeutics, Diseases
Inhibitors of Matrix Metalloproteinases
Wayne State University researchers and academic collaborators have prepared the first reported mechanism-based inhibitors for matrix metalloproteinases (MMPs). One of the novel compounds (SB-3CT) shows selectivity for the gelatinases (two members of the MMP family), which have been implicated in various pathological conditions including, but n...
Published: 6/22/2010   |   Inventor(s): Shahriar Mobashery, Rafael Fridman
Keywords(s):  
Category(s): Therapeutics, Life Science, Small molecule, Diseases
Using Flagellin to Prevent and to Treat Inflammation Associated Gram Negative Bacterial Infection
This technology provides a new method for treating inflammatory diseases by using a Gram negative bacterial component that results in increased tolerance and immunity. Background & Unmet Need: Despite advances of modern medicine, bacterial sepsis remains one of the major threats to human health worldwide. In the US alone, it affects approxima...
Published: 5/18/2010   |   Inventor(s): Fu-Shin Yu, Ashok Kumar, Jing Zhang, Linda Hazlett
Keywords(s): Anti-microbial, Asthma
Category(s): Therapeutics, Diseases, Life Science, Infectious disease
Hox B4
This invention is a novel therapy for cancer using Hox B4 to induce apoptosis in leukemia cell lines. Background & Unmet Need: B‑cell chronic lymphocytic leukemia is the most common type of leukemia in adults. The B cells grow uncontrollably and invade the bone marrow and blood where they crowd out the healthy cells. There is a need to...
Published: 5/18/2010   |   Inventor(s): Kamal Mubarak, Ramzi Mohammad, Robert Pauley, Larry Tait
Keywords(s): Anti-cancer, Gene, Protein
Category(s): Therapeutics, Life Science, Oncology, Diseases
Visual Prostheses Based Upon Fiber-Optic Uncaging of Neurotransmitter Substances
This drug delivery system selectively delivers drugs to various types of neurological cells to stimulate neurological tissue. This system can be used to develop visual and cortical prostheses. Background & Unmet Need: There are several types of prosthetic devices used for stimulation of neural tissue or neurons. There are visual prostheses us...
Published: 5/18/2010   |   Inventor(s): Patrick McAllister, Raymond Iezzi, Gregory Auner, Gary Abrams
Keywords(s): Drug Delivery, Neurological, Neuroscience
Category(s): Life Science, Neurological disorders, Therapeutics, Drug Delivery, Diseases
Establishment of a Prostate Carcinoma Bone Tumor Model in Mice
This technology is a new tumorigenic cell line from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/IF, when implanted in the femurs of nude mice, provide a xenograft tumor model of bone metastatic prostate carcinoma. The PC-3/IF cell lines are highly tumorigenic, with tumor cells replacing the marrow cells in the bon...
Published: 5/18/2010   |   Inventor(s): Gilda Hillman
Keywords(s): Animal Model, Prostate Cancer, Research Tool
Category(s): Animal models, Life Science, Research tools, Oncology, Diseases
Establishment of a Metastatic Prostate Carcinoma Tumor Model in Mice
This technology is a new tumorigenic cell line from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/PI, are highly tumorigenic when implanted in the prostate of nude mice, providing a xenograft tumor model of prostate carcinoma. In this model, lymph node metastases form from the primary tumor, similar to what occurs i...
Published: 5/18/2010   |   Inventor(s): Gilda Hillman
Keywords(s): Animal Model, Cancer, Prostate Cancer, Research Tool
Category(s): Animal models, Life Science, Oncology, Research tools, Diseases
Establishment of a New Renal Cell Carcinoma Cell Line and a New Experimental Renal Tumor Model
This technology is a tumor cell line from a primary papillary renal cell carcinoma that, when implanted in the kidney of nude mice, provides a xenograft tumor model of human renal cell carcinoma. Background & Unmet Need: Renal cell carcinoma, which occurs in the parenchyma of the kidney, is the most common type of renal cancer, accounting for ...
Published: 5/18/2010   |   Inventor(s): Gilda Hillman
Keywords(s): Animal Model, Cancer, Research Tool
Category(s): Animal models, Life Science, Oncology, Research tools, Diseases
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