Search Results - %22Life+Science%22+and+%22Diseases%22

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Microfluidic platforms for live-cell imaging and bio/pathomimetic tissue models

Background:Methodologies to image and quantify tissue models using high-content analysis (HCI) and functional analyses of 3D avatars are needed as such avatars better recapitulate the phenotype of pathobiological processes and better predict efficacy of, and resistance to, a wide variety of therapies. Furthermore, changes in morphometry, viability,...

Published: 2/14/2022 | Inventor(s): Bonnie Sloane, Kamiar Moin, Kyungmin Ji, Kingsley Osuala, Yong Xu, Hongen Tu

Keywords(s):

Category(s): Specialty compounds, Research tools, Oncology, Microfluidics, Life Science, Instrumentation, Imaging, Diseases, Devices, Cell lines

SALT-FORMULATED VALPROATE AS A TOPICAL ANTI-FUNGAL TREATMENT

In 2018, the global antifungal drugs market size was valued at USD 11.6 billion. Generally speaking, 54.3% of sales are prescription and 45.7% is over-the counter OTC/Alternative. It is anticipated that the OTC/Alternative portion of the global antifungal market will continue to grow. Science is indicating that both the number of systemic infections...

Published: 7/25/2025 | Inventor(s): Miriam Greenberg, Rania Deranieh

Keywords(s):

Category(s): Diseases, Infectious disease, Life Science, Small molecule, Pharmaceuticals

Antibacterial activity of natural compounds and their synthetic analogue: A potential new antibiotic with potent activity against multiple drug resistant bacterial pathogens

Our researchers have developed novel compounds that are potential new anti-infective therapeutics useful for treatment against the deadly bacteria MRSA (methicillin-resistant Staphylococcus aureus), VRE (vancomycin-resistant Enterococcus faecium), and several other well-known common infectious agents.Background & Unmet Need:Before antibiotics became...

Published: 8/28/2025 | Inventor(s): Hossein Salimnia, Fazlul Sarkar, Subhash Padhye, Bernhard Biersack

Keywords(s): Antibiotics, Anti-infective, Anti-microbial, Disease

Category(s): Biologicals, Diseases, Infectious disease, Life Science, Therapeutics

A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue

This invention is a new and simple method for the identification of active versus latent matrix metalloprotease enzymes (MMPs) in tissue. Background & Unmet Need: MMPs are involved in tumor progression and therefore are targets for anti-cancer drug therapies. However, most drug therapies directed at inhibition of MMPs have failed because there...

Published: 8/28/2025 | Inventor(s): Avraham Raz, Rafael Fridman, Pratima Nangia-Makker

Keywords(s): Biomarker, Cancer, Enzyme, Method

Category(s): Life Science, Oncology, Research tools, Antibodies, Therapeutics, Diseases