Search Results - "Life Science" and "Drug Delivery"




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Using Nanotechnology to Target Aggressive Cancers
Background: Nanotechnology is emerging as a promising tool to target cancer cells. Gold nanoparticles (GNPs) are preferentially taken up by cancer cells when injected into the blood stream and their safety has been demonstrated in human clinical trials. WSU researchers have designed a unique nanoparticle conjugate that combines a GNP with a small m...
Published: 8/15/2017   |   Inventor(s): Malathy Shekhar, Guangzhao Mao, Yanhua Zhang
Keywords(s):  
Category(s): Life Science, Oncology, Small molecule, Receptors/targets, Nano-based, Drug Delivery, Therapeutics, Diseases
An in vivo QQ-systemic protein delivery technology and applications
BackgroundThis invention contains a new composition of our researchers’ previously patented QQ-protein delivery technology and the in vivo applications of this protein delivery technology via systemic administered proteins for cancer diagnosis and therapy. Many proteins and peptides are used as highly specific and effective therapeutic agent...
Published: 8/3/2017   |   Inventor(s): Jianjun Wang, Qianqian Li, Quan Jiang, Feng Jiang, Michael Chopp
Keywords(s): Cancer Therapies, Drug Delivery
Category(s): Diagnostics, Drug Delivery, Life Science, Oncology, Research tools, Therapeutics
A protein-induced In situ cell-conversion technology and applications
BackgroundCell reprogramming and trans-differentiation are techniques that convert somatic cells of individuals into either stem cells, including embryonic and adult stem cells (reprogramming) or the other type of somatic cells (trans-differentiation). These techniques are usually performed in the cell culture settings using viral gene delivery an...
Published: 8/3/2017   |   Inventor(s): Jianjun Wang, Qianqian Li, Feng Jiang, Michael Chopp, Guojun Wu
Keywords(s): Cancer Therapies, Drug Delivery
Category(s): Drug Delivery, Life Science, Research tools
Generation of gp78 null mice
Generation of gp78 null mice WSU Tech#: 15-1291 Technology: Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis...
Published: 5/19/2017   |   Inventor(s): Avraham Raz, Andrei Golovko
Keywords(s):  
Category(s): Animal models, Biology, Biomedical, Biotechnology, Drug Delivery, Drug Discovery, Drug Screening, Genomics/Genetics, Life Science, Oncology, Research tools
Targeted Drug Delivery for Spinal Cord Injury
Technology Summary: WSU researchers have developed a new nanoparticle-drug conjugate for treating cervical spinal cord injury (SCI) that can restore respiratory function to the paralyzed hemi diaphragm. Using the nano-conjugate enables targeted delivery of the drug directly to the respiratory centers resulting in dramatically lower effective dosag...
Published: 5/19/2017   |   Inventor(s): Harry Goshgarian, Guangzhao Mao, Yi Zou, Sunxi Wang
Keywords(s): Central Nervous System, Drug Delivery, Neuroscience, Therapeutics
Category(s): Therapeutics, Life Science, Drug Delivery, Medical, Chemical Processing/Systhesis, Nanomaterials, Neurological disorders, Receptors/targets
Ruthenium-based caging of nitrile-containing enzyme inhibitors
Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the p...
Published: 4/29/2013   |   Inventor(s): Jeremy Kodanko, Claudia Turro
Keywords(s): Cancer, Pharmaceuticals
Category(s): Chemicals, Drug Delivery, Life Science, Physical Sciences, Other
Nanoparticle Method to Stabilize Suspension-Based pMDI HFA Formulations
Novel nanoparticle-based drug compositions and methods that improve and expand therapeutic drug delivery to the lungs through pressurized meter-dose inhalers (pMDIs). A large variety of approaches have been developed at WSU aimed at improving the aerosol characteristics and expanding the range of target species deliverable. These improved formulati...
Published: 4/23/2013   |   Inventor(s): Sandro da Rocha, Libo Wu
Keywords(s): Asthma, Drug Delivery, Formulation, Nanomaterials, Pharmaceuticals
Category(s): Drug Delivery, Life Science, Nano-based, Therapeutics
Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases
Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC...
Published: 9/10/2012   |   Inventor(s): David Oupicky, Jing Li
Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics
Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals
GlyB4 Fusion with Neuregulin Heparin-Targeting Domain to Block Neuregulin Signaling
We have harnessed this natural targeting ability of NRG by fusing the HBD of NRG to soluble HER4. This fusion protein retains high affinity heparin binding to heparin and to cells that express heparan sulfates resulting in a more potent NRG antagonist. In vivo, it is targeted to peripheral nerve segments where it blocks the activity of NRG as a Sch...
Published: 5/16/2011   |   Inventor(s): Jeffrey Loeb, Qunfang Lee
Keywords(s): Anti-cancer, Biotechnology, Cancer risk, Cancer Therapies, Drug Delivery, Drug Target, Epilepsy
Category(s): Life Science, Drug Delivery, Other
Visual Prostheses Based Upon Fiber-Optic Uncaging of Neurotransmitter Substances
This drug delivery system selectively delivers drugs to various types of neurological cells to stimulate neurological tissue. This system can be used to develop visual and cortical prostheses. Background & Unmet Need: There are several types of prosthetic devices used for stimulation of neural tissue or neurons. There are visual prostheses us...
Published: 5/18/2010   |   Inventor(s): Patrick McAllister, Raymond Iezzi, Gregory Auner, Gary Abrams
Keywords(s): Drug Delivery, Neurological, Neuroscience
Category(s): Life Science, Neurological disorders, Therapeutics, Drug Delivery, Diseases
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