Search Results - "Life Science" and "Research Tools"




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An in vivo QQ-systemic protein delivery technology and applications
BackgroundThis invention contains a new composition of our researchers’ previously patented QQ-protein delivery technology and the in vivo applications of this protein delivery technology via systemic administered proteins for cancer diagnosis and therapy. Many proteins and peptides are used as highly specific and effective therapeutic agent...
Published: 8/3/2017   |   Inventor(s): Jianjun Wang, Qianqian Li, Quan Jiang, Feng Jiang, Michael Chopp
Keywords(s): Cancer Therapies, Drug Delivery
Category(s): Diagnostics, Drug Delivery, Life Science, Oncology, Research tools, Therapeutics
A protein-induced In situ cell-conversion technology and applications
BackgroundCell reprogramming and trans-differentiation are techniques that convert somatic cells of individuals into either stem cells, including embryonic and adult stem cells (reprogramming) or the other type of somatic cells (trans-differentiation). These techniques are usually performed in the cell culture settings using viral gene delivery an...
Published: 8/3/2017   |   Inventor(s): Jianjun Wang, Qianqian Li, Feng Jiang, Michael Chopp, Guojun Wu
Keywords(s): Cancer Therapies, Drug Delivery
Category(s): Drug Delivery, Life Science, Research tools
Inhibitors of the ubiquitin E3 ligase BCA2 as anti-cancer therapeutic agents
Background:Breast cancer associated protein 2 (BCA2) is a ubiquitin E3 ligase found in invasive breast cancer. Studies have shown that by decreasing its activity, breast cancer cell growth and invasiveness are diminished. Targeting this ligase and inhibiting its activity could play a role in treatment of breast cancer. A molecular approach to in...
Published: 8/3/2017   |   Inventor(s): Angelika Burger, Andrew Westwell
Keywords(s): Analog or Analogue, Breast Cancer, Cancer, Disease, Drug Target, Enzyme
Category(s): Diseases, Oncology, Therapeutics, Life Science, Research tools
Generation of gp78 null mice
Generation of gp78 null mice WSU Tech#: 15-1291 Technology: Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis...
Published: 5/19/2017   |   Inventor(s): Avraham Raz, Andrei Golovko
Keywords(s):  
Category(s): Animal models, Biology, Biomedical, Biotechnology, Drug Delivery, Drug Discovery, Drug Screening, Genomics/Genetics, Life Science, Oncology, Research tools
Lyophilized Ready to Use & Load PCR Master Mix
PCR and Enzyme Lyophilization and Stabilization Formulation WSU Tech#: 13-1183Technology Summary: Wayne State University has discovered methods in which to formulate PCR related enzymes and reagents so they can be lyophilized. This stabilizes the proteins, nucleotides and buffers so they can be shipped and stored at room temperature. Our researc...
Published: 5/19/2017   |   Inventor(s): Jian-Ping Jin
Keywords(s):  
Category(s): Biological materials, Research tools, Life Science
CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines
CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines WSU Tech#: 15-1256 Technology Summary: CJ4.1A and CJ4.3C are rat conjunctival epithelial cell lines. The cell lines were developed to investigate antigen translocation across a mucosal barrier. Conjuctival epithelial cells from Fischer 344 rats were immortalized with pSV3(neo) resulting in...
Published: 1/30/2017   |   Inventor(s): Nancy O'Sullivan, Alfred Baylor III, Paul Montgomery
Keywords(s):  
Category(s): Cell lines, Life Science, Research tools
Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors
Background: Often referred to as the crucial "drug discovery tool", cell based technology is one of the most significant sectors of pharmaceutical research and development. Of particular importance has been the development of information-rich cellular assays that determine drug candidate efficacy and safety (target identification, valida...
Published: 8/14/2013   |   Inventor(s): Leon Carlock, Maria Cypher
Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics
Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines
Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging
Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LS...
Published: 4/26/2013   |   Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf
Keywords(s): Biotechnology, Imaging
Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools
Nano-beaker array formation process and its use for high-throughput loading and crystallization screening and other lab-on-the-chip applications
Wayne State University researchers have invented a novel process to make array patterns and its use for high-throughput screening of crystallization conditions, liquid solution applications, and other lab-on-the-chip applications. The formation process is a variation of ?particle lithography? in which microparticles such as polystyrene micro...
Published: 11/7/2011   |   Inventor(s): Guangzhao Mao, Daniel Sobczynski, Sunxi Wang, Eugene Xhahysa, Pedram Jahanian
Keywords(s): Nanotechnology
Category(s): Physical Sciences, Microfluidics, MEMS, Life Science, Research tools, Other
Peptide Antimicrobial
In vivo Display Technology for the Isolation of Antimicrobial Peptides Professor Philip R. Cunningham, Ph.D. Department of Biological Sciences @ Wayne State University Interest in peptides as antimicrobial agents has increased dramatically in recent years, driven primarily by the development of new technologies for producing, screening and analyz...
Published: 5/3/2011   |   Inventor(s): Philip Cunningham, Wes Colangelo
Keywords(s):  
Category(s): Pharmaceuticals, Life Science, Research tools, Assays, Biological materials, Protein/peptides
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