Search Results - %22Life+Science%22+and+%22Research+Tools%22

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Disulfide by Design 2.0: A web-based tool for disulfide engineering in proteins

Background:Immunoinformatics employs a computer-driven approach to identifying fragments of the target pathogen that would provide a suitable vaccine, avoiding potential safety concerns from the more traditional approach of using whole pathogens. Immunoinformatics now plays a crucial role in vaccine design, immunodiagnostic development, and antibody...

Published: 4/18/2022 | Inventor(s): Alan Dombkowski, Douglas Craig

Keywords(s): Coronavirus, COVID-19

Category(s): Life Science, Software, Simulation & Modeling, Research tools, Computer Software, Protein/peptides

Microfluidic platforms for live-cell imaging and bio/pathomimetic tissue models

Background:Methodologies to image and quantify tissue models using high-content analysis (HCI) and functional analyses of 3D avatars are needed as such avatars better recapitulate the phenotype of pathobiological processes and better predict efficacy of, and resistance to, a wide variety of therapies. Furthermore, changes in morphometry, viability,...

Published: 2/14/2022 | Inventor(s): Bonnie Sloane, Kamiar Moin, Kyungmin Ji, Kingsley Osuala, Yong Xu, Hongen Tu

Keywords(s):

Category(s): Specialty compounds, Research tools, Oncology, Microfluidics, Life Science, Instrumentation, Imaging, Diseases, Devices, Cell lines

Polyclonal and Monoclonal Antibodies to TPH1 and TPH2

This technology is a set of antibodies that is used with immunohistochemistry techniques to differentiate between tryptophan hydroxylase 1 and 2, enabling scientists to study how the two enzymes are differentially regulated. Background & Unmet Need: The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode enzymes in serotonin biosynthesis....

Published: 11/25/2024 | Inventor(s): Donald Kuhn

Keywords(s): Antibody, Assay, Immunoassay

Category(s): Life Science, Research tools, Biological materials, Antibodies

EL4-E2 Cell Line

This technology is a targeted anti-HER2 cell line that can be used as a research tool to develop HER2‑based vaccines for the treatment of aggressive breast cancer. Background & Unmet Need: The human epidermal growth factor 2 (HER2) is overexpressed in approximately 20-30% of all breast cancers and is associated with more aggressive and proliferative...

Published: 3/24/2022 | Inventor(s): Wei-Zen Wei

Keywords(s): Breast Cancer

Category(s): Cell lines, Life Science, Research tools, Biological materials

Transgenic Mice Carrying Wild Type Human Her-2 Under the Whey Acidic Promoter

This technology is an animal model designed to help pharmaceutical and biotechnology industries develop Her-2 based vaccines or immunotherapeutic agents. Background & Unmet Need: Her-2 positive breast cancer is a breast cancer that is positive for a protein called human epidermal growth factor receptor 2 (Her-2). Presence of Her-2 promotes...

Published: 5/13/2025 | Inventor(s): Wei-Zen Wei, Ye-Shih Ho, Marie Piechocki

Keywords(s): Animal Model, Breast Cancer, Research Tool

Category(s): Animal models, Life Science, Research tools

A Gene Knockout Mouse Model to Study Lung Disease and a Lung Disease Drug Target

Our researchers have created a gene knockout mouse model that lacks the cytochrome c oxidase subunit IV-2 in order to study the gene’s effects on controlling asthma. Background & Unmeet Need: Asthma is an inflammatory disease of the airways that affects 155 million people of all ages worldwide. Cytochome c oxidase (CcO) is a multi-subunit...

Published: 12/17/2024 | Inventor(s): Maik Huettemann, Lawrence Grossman, David Bassett

Keywords(s): Asthma, Disease, Drug Target, Gene, Knock-out, Lung, Mouse Model

Category(s): Animal models, Biological materials, Life Science, Research tools, Protein/peptides

Generation of gp78 null mice

Generation of gp78 null mice WSU Tech#: 15-1291 Technology: Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis,...

Published: 11/22/2021 | Inventor(s): Avraham Raz, Andrei Golovko

Keywords(s):

Category(s): Animal models, Biology, Biomedical, Biotechnology, Drug Delivery, Drug Discovery, Drug Screening, Genomics/Genetics, Life Science, Oncology, Research tools

Lyophilized Ready to Use & Load PCR Master Mix

PCR and Enzyme Lyophilization and Stabilization Formulation WSU Tech#: 13-1183Technology Summary: Wayne State University has discovered methods in which to formulate PCR related enzymes and reagents so they can be lyophilized. This stabilizes the proteins, nucleotides and buffers so they can be shipped and stored at room temperature. Our research...

Published: 2/28/2022 | Inventor(s): Jian-Ping Jin

Keywords(s):

Category(s): Biological materials, Research tools, Life Science

CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines

CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines WSU Tech#: 15-1256 Technology Summary: CJ4.1A and CJ4.3C are rat conjunctival epithelial cell lines. The cell lines were developed to investigate antigen translocation across a mucosal barrier. Conjuctival epithelial cells from Fischer 344 rats were immortalized with pSV3(neo) resulting...

Published: 12/5/2024 | Inventor(s): Nancy O'sullivan, Alfred Baylor Iii, Paul Montgomery

Keywords(s):

Category(s): Cell lines, Life Science, Research tools

Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging

Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI...

Published: 5/1/2018 | Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf

Keywords(s): Biotechnology, Imaging

Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools

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