Search Results - %22Life+Science%22+and+%22Therapeutics%22+and+%22Drug+delivery%22

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Fc-folate conjugate for the treatment of triple negative breast cancer

Approximately 13% of women in the United States will develop breast cancer according to the American Cancer Society. That makes breast cancer the second leading cause of cancer death in women right behind lung cancer. Triple negative breast cancer (TNBC) represents about 10 – 20% of all breast cancers. Triple negative refers to cancer cells...

Published: 12/7/2022 | Inventor(s): Cecilia Speyer

Keywords(s): Anti-cancer, Breast Cancer, Cancer, Cancer Therapies

Category(s): Antibodies, Assays, Biology, Biomedical, Chemical Processing/Synthesis, Diseases, Drug Delivery, Life Science, Oncology, Protein/peptides, Receptors/targets, Small molecule, Therapeutics

Using nanotechnology to target aggressive cancers with a novel small molecule inhibitor of the DNA damage tolerance pathway

Background: Nanotechnology is emerging as a promising tool to target cancer cells. Gold nanoparticles (GNPs) are preferentially taken up by cancer cells when injected into the blood stream and their safety has been demonstrated in human clinical trials. WSU researchers have designed a unique nanoparticle conjugate that combines a GNP with a small molecule...

Published: 8/29/2018 | Inventor(s): Malathy Shekhar, Guangzhao Mao, Yanhua Zhang

Keywords(s):

Category(s): Life Science, Oncology, Small molecule, Receptors/targets, Nano-based, Drug Delivery, Therapeutics, Diseases

An in vivo QQ-systemic protein delivery technology and applications

BackgroundThis invention contains a new composition of our researchers’ previously patented QQ-protein delivery technology and the in vivo applications of this protein delivery technology via systemic administered proteins for cancer diagnosis and therapy. Many proteins and peptides are used as highly specific and effective therapeutic agents....

Published: 11/9/2021 | Inventor(s): Jianjun Wang, Qianqian Li, Quan Jiang, Feng Jiang, Michael Chopp

Keywords(s): Cancer Therapies, Drug Delivery

Category(s): Diagnostics, Drug Delivery, Life Science, Oncology, Research tools, Therapeutics

Targeted Drug Delivery for Spinal Cord Injury

Technology Summary: WSU researchers have developed a new nanoparticle-drug conjugate for treating cervical spinal cord injury (SCI) that can restore respiratory function to the paralyzed hemi diaphragm. Using the nano-conjugate enables targeted delivery of the drug directly to the respiratory centers resulting in dramatically lower effective dosages...

Published: 11/11/2021 | Inventor(s): Harry Goshgarian, Guangzhao Mao, Yi Zou, Sunxi Wang

Keywords(s): Central Nervous System, Drug Delivery, Neuroscience, Therapeutics

Category(s): Therapeutics, Life Science, Drug Delivery, Medical, Chemical Processing/Systhesis, Nanomaterials, Neurological disorders, Receptors/targets

Nanoparticle Method to Stabilize Suspension-Based pMDI HFA Formulations

Novel nanoparticle-based drug compositions and methods that improve and expand therapeutic drug delivery to the lungs through pressurized meter-dose inhalers (pMDIs). A large variety of approaches have been developed at WSU aimed at improving the aerosol characteristics and expanding the range of target species deliverable. These improved formulations...

Published: 11/11/2021 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Asthma, Drug Delivery, Formulation, Nanomaterials, Pharmaceuticals

Category(s): Drug Delivery, Life Science, Nano-based, Therapeutics

Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases

Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC50...

Published: 11/11/2021 | Inventor(s): David Oupicky, Jing Li

Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals

Visual Prostheses Based Upon Fiber-Optic Uncaging of Neurotransmitter Substances

This drug delivery system selectively delivers drugs to various types of neurological cells to stimulate neurological tissue. This system can be used to develop visual and cortical prostheses. Background & Unmet Need: There are several types of prosthetic devices used for stimulation of neural tissue or neurons. There are visual prostheses used...

Published: 8/28/2019 | Inventor(s): Patrick Mcallister, Raymond Iezzi, Gregory Auner, Gary Abrams

Keywords(s): Drug Delivery, Neurological, Neuroscience

Category(s): Life Science, Neurological disorders, Therapeutics, Drug Delivery, Diseases

Nanometer-Sized Drug Delivery Devices (Nanoparticles) that Demonstrate High Encapsulation Efficiency and Sustained Release of Water-Soluble Drugs and their Preparation

This technology is a nano‑meter size drug delivery system that is capable of encapsulating water‑soluble drugs with high efficiency, allowing sustained release of the drug in the body. Background & Unmet Need: There are a number of biological barriers to cellular drug delivery. Simple diffusion across the cell membrane is feasible...

Published: 4/9/2019 | Inventor(s): Jayanth Panyam, Mahesh Chavanpatil

Keywords(s): Drug Delivery, Nanomaterials

Category(s): Drug Delivery, Life Science, Nanomaterials, Therapeutics

Improved pDMI Inhaler Formulations

Novel biodegradable, non-toxic nanoparticles that act as stabilizing excipients with a wide variety of suspension drug candidates including polar & non-polar drug particles, bio-macromolecules (proteins/peptides), gene therapies (DNA/siRNA) as well as amorphous and crystalline therapeutics have been developed which provide a platform for improving...

Published: 11/11/2021 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Asthma, Drug Delivery, Formulation, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Life Science, Therapeutics, Nano-based