Search Results - "Life Science" and "Therapeutics" and "Small molecule"




5 Results Sort By:
Inhibitors of Matrix Metalloproteinases
Wayne State University researchers and academic collaborators have prepared the first reported mechanism-based inhibitors for matrix metalloproteinases (MMPs). One of the novel compounds (SB-3CT) shows selectivity for the gelatinases (two members of the MMP family), which have been implicated in various pathological conditions including, but n...
Published: 6/22/2010   |   Inventor(s): Shahriar Mobashery, Rafael Fridman
Keywords(s):  
Category(s): Therapeutics, Life Science, Small molecule, Diseases
Novel Prenyl Transferase Inhibitors
A series of farnesol and geranylgeraniol analogs that block the prenylation of proteins in cells. The diphosphate derivatives of these compounds are potent inhibitors of protein prenyltransferases in vitro. One allylfarnesol compound specifically inhibits the farnesylation of proteins and one allylgeranylgeraniol compound specifically inhibits the...
Published: 5/18/2010   |   Inventor(s): Richard Gibbs
Keywords(s):  
Category(s): Therapeutics, Life Science, Small molecule
Tumor Targeting by Small Molecule Therapeutics for a Proton-Coupled Folate Transporter (PCFT)
WSU researchers, in collaboration with Duquesne University, have isolated a unique series of pyrrolopyrimidine antifolate analogs that show selective cytotoxicity toward solid tumors such as ovarian, prostate, or breast cancer cells. Background & Unmet Need: Protein-coupled folate transporters (PCFT) play an important role in intestinal folate ...
Published: 5/6/2010   |   Inventor(s): Larry Matherly, Aleem Gangjee
Keywords(s): Analog or Analogue, Breast Cancer, Cancer Therapies, Drug Delivery, Ovarian Cancer, Prostate Cancer
Category(s): Therapeutics, Life Science, Small molecule, Oncology, Diseases
Designer Aminoglycosides
Wayne State University researchers have synthesized a series of novel aminoglycoside antibiotics that have shown enhanced antibacterial activity, low susceptibility to existing resistance mechanisms and low toxicity when compared to currently marketed aminoglycosides. Aminoglycoside antibiotics have been used against a wide variety of bacteria...
Published: 5/6/2010   |   Inventor(s): Shahriar Mobashery, Lakshmi Kotra, Jalal Haddad
Keywords(s): Antibiotics
Category(s): Therapeutics, Life Science, Small molecule, Diseases, Infectious disease
Novel Hybrid Series of Compound Derived from 2-Aminotetralin and Piperazine Based Derivatives: Characterization for D1, D2, D3, D4 and other Serotonin Receptor Subtypes Binding
A series of compounds derived from 2-aminotetralin and piperazine fragments have been synthesized, which exhibit high CNS activity in vivo and in vitro. Some of the selected lead compounds have exhibited potent in vivo activity in a Parkinson?s disease animal model with long extended duration of action. In particular, these compounds show high...
Published: 5/6/2010   |   Inventor(s): Aloke Dutta, Xiang-Shu Fei
Keywords(s):  
Category(s): Therapeutics, Diseases, Life Science, Small molecule, Neurological disorders