Search Results - "Research Tools"




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An in vivo QQ-systemic protein delivery technology and applications
BackgroundThis invention contains a new composition of our researchers’ previously patented QQ-protein delivery technology and the in vivo applications of this protein delivery technology via systemic administered proteins for cancer diagnosis and therapy. Many proteins and peptides are used as highly specific and effective therapeutic agent...
Published: 8/3/2017   |   Inventor(s): Jianjun Wang, Qianqian Li, Quan Jiang, Feng Jiang, Michael Chopp
Keywords(s): Cancer Therapies, Drug Delivery
Category(s): Diagnostics, Drug Delivery, Life Science, Oncology, Research tools, Therapeutics
A protein-induced In situ cell-conversion technology and applications
BackgroundCell reprogramming and trans-differentiation are techniques that convert somatic cells of individuals into either stem cells, including embryonic and adult stem cells (reprogramming) or the other type of somatic cells (trans-differentiation). These techniques are usually performed in the cell culture settings using viral gene delivery an...
Published: 8/3/2017   |   Inventor(s): Jianjun Wang, Qianqian Li, Feng Jiang, Michael Chopp, Guojun Wu
Keywords(s): Cancer Therapies, Drug Delivery
Category(s): Drug Delivery, Life Science, Research tools
Inhibitors of the ubiquitin E3 ligase BCA2 as anti-cancer therapeutic agents
Background:Breast cancer associated protein 2 (BCA2) is a ubiquitin E3 ligase found in invasive breast cancer. Studies have shown that by decreasing its activity, breast cancer cell growth and invasiveness are diminished. Targeting this ligase and inhibiting its activity could play a role in treatment of breast cancer. A molecular approach to in...
Published: 8/3/2017   |   Inventor(s): Angelika Burger, Andrew Westwell
Keywords(s): Analog or Analogue, Breast Cancer, Cancer, Disease, Drug Target, Enzyme
Category(s): Diseases, Oncology, Therapeutics, Life Science, Research tools
Generation of gp78 null mice
Generation of gp78 null mice WSU Tech#: 15-1291 Technology: Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis...
Published: 5/19/2017   |   Inventor(s): Avraham Raz, Andrei Golovko
Keywords(s):  
Category(s): Animal models, Biology, Biomedical, Biotechnology, Drug Delivery, Drug Discovery, Drug Screening, Genomics/Genetics, Life Science, Oncology, Research tools
"Generation of an affinity-purified rabbit anti-CREBH polyclonal antibody"
Generation of an Affinity-Purified Rabbit Anti-CREBH Polyclonal Antibody WSU Tech#: 15-1271 Technology Summary: CREBH (also called CREB3L3) is a stress-inducible metabolic regulator that plays key roles in hepatic lipolysis, fatty acid oxidation, gluconeogenesis, and lipogenesis. CREBH is critically involved in fatty liver disease and its assoc...
Published: 5/19/2017   |   Inventor(s): Kezhong Zhang
Keywords(s):  
Category(s): Research tools, Antibodies, Assays
Lyophilized Ready to Use & Load PCR Master Mix
PCR and Enzyme Lyophilization and Stabilization Formulation WSU Tech#: 13-1183Technology Summary: Wayne State University has discovered methods in which to formulate PCR related enzymes and reagents so they can be lyophilized. This stabilizes the proteins, nucleotides and buffers so they can be shipped and stored at room temperature. Our researc...
Published: 5/19/2017   |   Inventor(s): Jian-Ping Jin
Keywords(s):  
Category(s): Biological materials, Research tools, Life Science
GENERATION OF 5-FLUOROURACIL + OXALIPLATIN RESISTANT COLON CANCER CELLS: A TOOL TO STUDY CANCER RECURRENCE AND DRUG RESISTANCE
Generation of 5-Fluorouracil + Oxaliplatin Resistant Colon Cancer Cells WSU Tech#: 13-1154 Technology Summary: A significant obstacle for the successful management of patients with colorectal cancer (CRC) is intrinsic drug resistance or, in patients who respond to chemotherapy, acquired drug resistance. Drug resistance can occur through a v...
Published: 5/19/2017   |   Inventor(s): Adhip Majumdar, Yingjie Yu
Keywords(s):  
Category(s): Biomedical, Biotechnology, Cell lines, Characterization, Drug Discovery, Oncology, Research tools
CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines
CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines WSU Tech#: 15-1256 Technology Summary: CJ4.1A and CJ4.3C are rat conjunctival epithelial cell lines. The cell lines were developed to investigate antigen translocation across a mucosal barrier. Conjuctival epithelial cells from Fischer 344 rats were immortalized with pSV3(neo) resulting in...
Published: 1/30/2017   |   Inventor(s): Nancy O'Sullivan, Alfred Baylor III, Paul Montgomery
Keywords(s):  
Category(s): Cell lines, Life Science, Research tools
Whole body model of a 10-year-old child for pediatric injury prediction
Technology A computational whole body 10-year-old (YO) FE (Finite Element) model which is anatomically accurate based on the clinical images. The model was composed ofhigh quality elements for accurate stress/strain predictions and possessed high biofidelity to accurately predict body responses under external mechanical loadings. Preliminary verifi...
Published: 10/11/2013   |   Inventor(s): Haojie Mao, King-Hay Yang
Keywords(s):  
Category(s): Automotive & Transportation, Research tools
Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors
Background: Often referred to as the crucial "drug discovery tool", cell based technology is one of the most significant sectors of pharmaceutical research and development. Of particular importance has been the development of information-rich cellular assays that determine drug candidate efficacy and safety (target identification, valida...
Published: 8/14/2013   |   Inventor(s): Leon Carlock, Maria Cypher
Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics
Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines
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