Search Results - Antibodies

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Fc-folate conjugate for the treatment of triple negative breast cancer

Approximately 13% of women in the United States will develop breast cancer according to the American Cancer Society. That makes breast cancer the second leading cause of cancer death in women right behind lung cancer. Triple negative breast cancer (TNBC) represents about 10 – 20% of all breast cancers. Triple negative refers to cancer cells...

Published: 12/7/2022 | Inventor(s): Cecilia Speyer

Keywords(s): Anti-cancer, Breast Cancer, Cancer, Cancer Therapies

Category(s): Antibodies, Assays, Biology, Biomedical, Chemical Processing/Synthesis, Diseases, Drug Delivery, Life Science, Oncology, Protein/peptides, Receptors/targets, Small molecule, Therapeutics

Polyclonal and Monoclonal Antibodies to TPH1 and TPH2

This technology is a set of antibodies that is used with immunohistochemistry techniques to differentiate between tryptophan hydroxylase 1 and 2, enabling scientists to study how the two enzymes are differentially regulated. Background & Unmet Need: The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode enzymes in serotonin biosynthesis....

Published: 11/19/2021 | Inventor(s): Donald Kuhn

Keywords(s): Antibody, Assay, Immunoassay

Category(s): Life Science, Research tools, Biological materials, Antibodies

"Generation of an affinity-purified rabbit anti-CREBH polyclonal antibody"

Generation of an Affinity-Purified Rabbit Anti-CREBH Polyclonal Antibody WSU Tech#: 15-1271Technology Summary: CREBH (also called CREB3L3) is a stress-inducible metabolic regulator that plays key roles in hepatic lipolysis, fatty acid oxidation, gluconeogenesis, and lipogenesis. CREBH is critically involved in fatty liver disease and its associated...

Published: 2/28/2022 | Inventor(s): Kezhong Zhang

Keywords(s):

Category(s): Research tools, Antibodies, Assays

SIRT2 Antibody

This technology is a novel rabbit antibody for SIRT2 ( Sirtuin 2) designed to follow human SIRT2 proteins in order to determine their role in gene regulation and apoptosis.Background & Unmet Need:The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress...

Published: 2/18/2022 | Inventor(s): Michael Tainsky, Sylvia Dryden

Keywords(s): Compound, Protein

Category(s): Diagnostic, Antibodies, Life Science, Research tools

Antibodies to a Novel Cell Cycle and Apoptosis Regulatory Protein (CARP) -1

Wayne State University researchers have identified a novel cDNA which encodes a pro-apoptotic protein called CARP-1 (Cell Cycle and Apoptosis Regulatory Protein-1), which is expressed in many cancer cell types including breast and colon carcinoma cells. This novel cDNA can be used as a diagnostic and prognostic tool for many types of cancer. Background...

Published: 2/8/2022 | Inventor(s): Arun Rishi, Joseph Fontana

Keywords(s): Antibody, Breast Cancer, Cancer, Drug Target

Category(s): Diagnostic, Life Science, Research tools, Antibodies

A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue

This invention is a new and simple method for the identification of active versus latent matrix metalloprotease enzymes (MMPs) in tissue. Background & Unmet Need: MMPs are involved in tumor progression and therefore are targets for anti-cancer drug therapies. However, most drug therapies directed at inhibition of MMPs have failed because there...

Published: 11/22/2021 | Inventor(s): Avraham Raz, Rafael Fridman, Pratima Nangia-Makker

Keywords(s): Biomarker, Cancer, Diagnostics, Enzyme, Method

Category(s): Life Science, Oncology, Research tools, Antibodies, Therapeutics, Diseases