Search Results - Biologicals

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Topical treatment with TGFbeta3 to facilitate skin and corneal wound healing in diabetic patients

Background: Diabetes affects approximately 170 million people worldwide, including 20.8 million in the USA, and by 2030 these numbers are projected to double. Diabetics often experience slow or limited wound healing. Slow wound healing allows longer time for the development of infections and can contribute to the formation of bed sores and ulcers....

Published: 9/16/2019 | Inventor(s): Fu-Shin Yu

Keywords(s): Diabetes

Category(s): Medical, Biologicals, Biomedical, Drug Discovery, Metabolic disorders, Protein/peptides, Therapeutics, Life Science

Modified Ectodomain of Human EGFR as a Potential Anticancer Agent

Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion of...

Published: 8/16/2021 | Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu

Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics

Category(s): Life Science, Biologicals, Diseases, Oncology

Topical IL-1Ra (anakinra) in the form of gel to treat persistent diabetic skin and corneal wounds

BackgroundAnakinra (aka. Kineret) is a recombinant human IL-1Ra that was developed by Amgen. It is currently used to treat moderately to severely active rheumatoid arthritis, but also treats neonatal-onset multisystem inflammatory disease (NOMID). Anakinra is given as an IV dose and the drug is no longer under patent. The properties of Anakinra are...

Published: 9/3/2019 | Inventor(s): Fu-Shin Yu

Keywords(s):

Category(s): Biologicals, Drug Discovery, Pharmaceuticals, Therapeutics

Antibacterial activity of natural compounds and their synthetic analogue: A potential new antibiotic with potent activity against multiple drug resistant bacterial pathogens

Our researchers have developed novel compounds that are potential new anti-infective therapeutics useful for treatment against the deadly bacteria MRSA (methicillin-resistant Staphylococcus aureus), VRE (vancomycin-resistant Enterococcus faecium), and several other well-known common infectious agents.Background & Unmet Need:Before antibiotics became...

Published: 8/9/2022 | Inventor(s): Hossein Salimnia, Fazlul Sarkar, Subhash Padhye, Bernhard Biersack

Keywords(s): Analog or Analogue, Antibiotics, Anti-infective, Anti-microbial, Disease

Category(s): Biologicals, Diseases, Infectious disease, Life Science, Therapeutics

Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases

Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC50...

Published: 11/11/2021 | Inventor(s): David Oupicky, Jing Li

Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals

Peptides Representing Genus-Specific Chlamydial Antigens for Vaccine Peptide Vaccines for Chlamydia to be Delivered Orally or by Other Mucosal Routes

Wayne State University inventors have developed several peptide Chlamydia vaccine candidates that are genus specific, conformational, and easy to manufacture. Background & Unmet Need: Despite increased surveillance and treatment, Chlamydial genital tract infections continue to rise. It is estimated that over 20 million new cases of infection...

Published: 12/7/2022 | Inventor(s): Judith Whittum-Hudson, Alan Hudson

Keywords(s): Vaccines

Category(s): Biologicals, Life Science, Therapeutics, Vaccines

Novel Mammalian Putative Phosphatidylinositol-4-Phosphate-5-Kinase

This invention is a novel mammalian gene involved in membrane trafficking, more specifically, insulin‑induced translocation of the fat/muscle-specific glucose transporter GLUT4. Background & Unmet Need: Both Type I (Juvenile onset) and Type II (Maturity onset) Diabetes Mellitus result in a profound state of high glucose in the circulation....

Published: 2/14/2022 | Inventor(s): Assia Shisheva

Keywords(s): DNA, Drug Target, Therapeutics

Category(s): Diseases, Life Science, Metabolic disorders, Therapeutics, Biologicals