Search Results - Drug Discovery




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Generation of gp78 null mice
Generation of gp78 null mice WSU Tech#: 15-1291 Technology: Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis...
Published: 5/19/2017   |   Inventor(s): Avraham Raz, Andrei Golovko
Keywords(s):  
Category(s): Animal models, Biology, Biomedical, Biotechnology, Drug Delivery, Drug Discovery, Drug Screening, Genomics/Genetics, Life Science, Oncology, Research tools
Use of Raman Spectroscopy to Decrease Time to Identify the Species of Candida and bacterial Growth in Cultures.
Use of Raman Spectroscopy to Decrease Time to Identify MRSA Verses MSSA and the Subspecies of Candida and bacterial Growth in Cultures WSU Tech#: 15-1270 Technology Summary: New Technology for the identification of MRSA versus MSSA and sub-species for both bacterial staph Aureus (SA) and Candida in one package, using Raman Spectroscopy. This wo...
Published: 5/19/2017   |   Inventor(s): Nitin Chouthai
Keywords(s):  
Category(s): Imaging, Drug Discovery, Infectious disease, Instrumentation, Software
GENERATION OF 5-FLUOROURACIL + OXALIPLATIN RESISTANT COLON CANCER CELLS: A TOOL TO STUDY CANCER RECURRENCE AND DRUG RESISTANCE
Generation of 5-Fluorouracil + Oxaliplatin Resistant Colon Cancer Cells WSU Tech#: 13-1154 Technology Summary: A significant obstacle for the successful management of patients with colorectal cancer (CRC) is intrinsic drug resistance or, in patients who respond to chemotherapy, acquired drug resistance. Drug resistance can occur through a v...
Published: 5/19/2017   |   Inventor(s): Adhip Majumdar, Yingjie Yu
Keywords(s):  
Category(s): Biomedical, Biotechnology, Cell lines, Characterization, Drug Discovery, Oncology, Research tools
Long non-protein-coding RNA molecules as therapeutics for epilepsy.
Long Non-Coding RNA Molecules as Therapeutics for Epilepsy WSU Tech#: 12-1089 Technology Summary: Long Non-coding RNA (lncRNA) were first described in 2002 from mouse, making this a relatively new technology. lncRNA transcripts far exceed the number of protein coding mRNAs in the mammalian transcriptome, but in lower copy numbers. Invento...
Published: 5/19/2017   |   Inventor(s): Jeffrey Loeb, Leonard Lipovich
Keywords(s):  
Category(s): Medical, Bioinformatics, Biomedical, Biotechnology, Diagnostic, Diagnostics, Drug Discovery, Pharmaceuticals, Therapeutics
CARP-1/CCAR1 Functional Mimetics (CFMs): Novel small molecule suppressors of human breast cancer cell growth.
BackgroundCARP-1 (Cell cycle and apoptosis regulator protein) is a regulator of cell growth signaling. CARP-1 plays an important role in apoptosis (cell death) induction in human breast cancer (HBC) cells in the presence of the chemotherapy agent Adriamycin. The researchers have found that CARP-1 inhibits cell growth by binding with the anapha...
Published: 5/19/2017   |   Inventor(s): Arun Rishi
Keywords(s):  
Category(s): Medical, Drug Discovery, Life Science, Oncology, Pharmaceuticals
Topical treatment with TGFbeta3 to facilitate skin and corneal wound healing in diabetic patients
Topical Treatment with TGFb3 to Facilitate Skin and Corneal Wound Healing in Diabetic Patients WSU Tech#: 14-1207 Technology Summary: TGFb3 has been implicated in the reduction of scar formation in wound healing. Renovo Group PLC, is a European based biopharmaceutical company developing drugs to reduce scaring, improve wound healing and enhance...
Published: 2/10/2017   |   Inventor(s): Fu-Shin Yu
Keywords(s):  
Category(s): Medical, Biologicals, Biomedical, Drug Discovery, Metabolic disorders, Protein/peptides, Therapeutics, Life Science
Topical IL-1Ra (anakinra) in the form of gel to treat persistent diabetic skin and corneal wounds
BackgroundAnakinra (aka. Kineret) is a recombinant human IL-1Ra that was developed by Amgen. It is currently used to treat moderately to severely active rheumatoid arthritis, but also treats neonatal-onset multisystem inflammatory disease (NOMID). Anakinra is given as an IV dose and the drug is no longer under patent. The properties of Anakinra a...
Published: 5/25/2016   |   Inventor(s): Fu-Shin Yu
Keywords(s):  
Category(s): Biologicals, Drug Discovery, Pharmaceuticals, Therapeutics
An In Vitro Model System for Studying Development of Human Preneoplastic Breast Disease
This technology is a novel model/assay system that recapitulates in vitro the in vivo processes that lead to breast cancer development and progression from preneoplastic tissue. This model is the first that demonstrates in vitro the de novo development and neoplastic conversion of functional alveolar units. Background & Unmet Need: Although ...
Published: 5/7/2010   |   Inventor(s): Malathy Shekhar, Larry Tait
Keywords(s): Assay, Breast Cancer
Category(s): Drug Discovery, Assays, Life Science, Oncology, Research tools, Diseases