Search Results - Neurological+disorders

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Targeted Drug Delivery for Spinal Cord Injury

Technology Summary: WSU researchers have developed a new nanoparticle-drug conjugate for treating cervical spinal cord injury (SCI) that can restore respiratory function to the paralyzed hemi diaphragm. Using the nano-conjugate enables targeted delivery of the drug directly to the respiratory centers resulting in dramatically lower effective dosages...

Published: 11/11/2021 | Inventor(s): Harry Goshgarian, Guangzhao Mao, Yi Zou, Sunxi Wang

Keywords(s): Central Nervous System, Drug Delivery, Neuroscience, Therapeutics

Category(s): Therapeutics, Life Science, Drug Delivery, Medical, Chemical Processing/Systhesis, Nanomaterials, Neurological disorders, Receptors/targets

Repurposing AKT Inhibitors for the Treatment of Protein Misfolding and Protein Trafficking Diseases

WSU researchers have generated a reagent to understand the degenerative processes occurring in Pelizaeus‑Merzbacher disease (PMD) and to study the intracellular signaling that occurs because of these diseased processes. They have deduced that the use of AKT inhibitors may reduce disease severity in patients with a wide range of degenerative diseases. Background...

Published: 2/8/2022 | Inventor(s): Alexander Gow, Cherie Southwood

Keywords(s): Alzheimer's Disease, Anti-cancer, Neuro-disorders, Parkinson's

Category(s): Life Science, Neurological disorders, Therapeutics, Diseases

Visual Prostheses Based Upon Fiber-Optic Uncaging of Neurotransmitter Substances

This drug delivery system selectively delivers drugs to various types of neurological cells to stimulate neurological tissue. This system can be used to develop visual and cortical prostheses. Background & Unmet Need: There are several types of prosthetic devices used for stimulation of neural tissue or neurons. There are visual prostheses used...

Published: 8/28/2019 | Inventor(s): Patrick Mcallister, Raymond Iezzi, Gregory Auner, Gary Abrams

Keywords(s): Drug Delivery, Neurological, Neuroscience

Category(s): Life Science, Neurological disorders, Therapeutics, Drug Delivery, Diseases

CNS Compounds Specific for the Monoamine Transporter Systems

This invention includes novel compounds that have neuropharmacological activity with the dopamine receptor and the method of using them to treat central nervous system disorders. Background & Unmet Need: The dopamine transporter (DAT) plays an important role in processes of the central nervous system. In cocaine addiction, binding of cocaine...

Published: 2/8/2022 | Inventor(s): Aloke Dutta

Keywords(s): Addiction Treatment, Antidepressants, Neuroscience, Parkinson's

Category(s): Therapeutics, Life Science, Diseases, Neurological disorders

Novel Hybrid Series of Compound Derived from 2-Aminotetralin and Piperazine Based Derivatives: Characterization for D1, D2, D3, D4 and other Serotonin Receptor Subtypes Binding

A series of compounds derived from 2-aminotetralin and piperazine fragments have been synthesized, which exhibit high CNS activity in vivo and in vitro. Some of the selected lead compounds have exhibited potent in vivo activity in a Parkinson’s disease animal model with long extended duration of action. In particular, these compounds show high...

Published: 11/19/2021 | Inventor(s): Aloke Dutta, Xiang-Shu Fei

Keywords(s):

Category(s): Therapeutics, Diseases, Life Science, Small molecule, Neurological disorders