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Ruthenium-based caging of nitrile-containing enzyme inhibitors

Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the pathophysiology...

Published: 10/27/2023 | Inventor(s): Jeremy Kodanko, Claudia Turro

Keywords(s): Cancer, Pharmaceuticals

Category(s): Chemicals, Drug Delivery, Life Science, Physical Sciences, Other

Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging

Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI...

Published: 5/1/2018 | Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf

Keywords(s): Biotechnology, Imaging

Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools

Nano-beaker array formation process and its use for high-throughput loading and crystallization screening and other lab-on-the-chip applications

Wayne State University researchers have invented a novel process to make array patterns and its use for high-throughput screening of crystallization conditions, liquid solution applications, and other lab-on-the-chip applications. The formation process is a variation of “particle lithography” in which microparticles such as polystyrene microparticles...

Published: 9/17/2019 | Inventor(s): Guangzhao Mao, Daniel Sobczynski, Sunxi Wang, Eugene Xhahysa, Pedram Jahanian

Keywords(s): Nanotechnology

Category(s): Physical Sciences, Microfluidics, MEMS, Life Science, Research tools, Other

GlyB4 Fusion with Neuregulin Heparin-Targeting Domain to Block Neuregulin Signaling

We have harnessed this natural targeting ability of NRG by fusing the HBD of NRG to soluble HER4. This fusion protein retains high affinity heparin binding to heparin and to cells that express heparan sulfates resulting in a more potent NRG antagonist. In vivo, it is targeted to peripheral nerve segments where it blocks the activity of NRG as a Schwann...

Published: 12/6/2022 | Inventor(s): Jeffrey Loeb, Qunfang Lee

Keywords(s): Anti-cancer, Biotechnology, Cancer risk, Cancer Therapies, Drug Delivery, Drug Target, Epilepsy

Category(s): Life Science, Drug Delivery, Other

First Row Transition Metal Diazadiene Film Growth Precursors

Technology Overview Wayne State University researchers have developed a new class of thermally stable, volatile transition chemical compounds that have desirable properties for the growth of thin films of transition metal-containing materials. These novel film precursors have high potential for use in the growth of thin films by chemical vapor...

Published: 3/12/2018 | Inventor(s): Charles Winter, Thomas Knisley

Keywords(s):

Category(s): Chemicals, Materials, Other, Physical Sciences, Thin films

Vibro-acoustic metamaterial with mass and flexible stem array

WSU researchers have developed a novel device combining the effects of negative effective elastic modulus and negative effective mass, acting as local resonators that can damp out vibrations and sound at multiple frequencies. This class of metamaterials has the superior ability to attenuate sound and have a much greater ability to block dynamic disturbances....

Published: 9/10/2021 | Inventor(s): Md Tofiqul Islam, Golam Newaz, Mohammad Hailat

Keywords(s):

Category(s): Materials, Industrial & Manufacturing, Other, Physical Sciences, Building & Construction

Guidance and Control System for Under Actuated Marine Surface Vessels

WSU researchers have developed a guidance system that yields a faster convergence rate of the ship to its desired trajectory than existing systems. The new algorithm varies the radius in the guidance algorithm exponentially as opposed to linear variations in existing schemes. This was done to prevent the system from over-reacting for small cross track...

Published: 9/10/2021 | Inventor(s): Nabil Chalhoub, Nassim Khaled

Keywords(s):

Category(s): Physical Sciences, Automotive & Transportation, Other, Software

Fuel Injector to Work as an Ionization Sensor and as an Injection Signal Detector in Electronically Controlled Fuel Injection Systems in Diesel and Direct Injection Gasoline Engines

Wayne State researchers have created an invention which uses one element in the engine, the fuel injector, to perform four tasks, injecting fuel, acting as an injection pulse detector, operating as a fuel injector malfunction detector and working as an ion sensor without modifying the fuel injector. Internal combustion engine control has become more...

Published: 12/5/2022 | Inventor(s): Fadi Estefanous

Keywords(s):

Category(s): Electronics, Automotive & Transportation, Physical Sciences, Powertrain, Sensors, Other

Austenitic (Non-Magnetic) Structural Steel

Wayne State University research has yielded both a novel composition and a lower cost processing technique for the creation of austenitic non-magnetic structural steel. This steel has advantages that include a high work hardening rate, good corrosion resistance, combination of strength and ductility and good creep resistance. Use of this steel...

Published: 3/3/2020 | Inventor(s): Susil Putatunda

Keywords(s): Transportation

Category(s): Materials, Automotive & Transportation, High strength, Other, Physical Sciences, Building & Construction, Industrial & Manufacturing

Broad Temperature Range MIS Hydrogen Sensors

WSU researchers have developed hydrogen sensors that differ from previous devices by employing aluminum nitride as an insulator in a metal insulator semiconductor structure. These new structures show a marked specificity for hydrogen under a wide range of conditions. Several prototype sensors with various applications have been tested results are available...

Published: 3/3/2020 | Inventor(s): Flaminia Serina, Gregory Auner, Ka Yuen Simon Ng, Ratna Naik

Keywords(s): Device, Security

Category(s): Sensors, Physical Sciences, Automotive & Transportation, Other

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