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Ruthenium-based caging of nitrile-containing enzyme inhibitors

Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the pathophysiology...

Published: 10/27/2023 | Inventor(s): Jeremy Kodanko, Claudia Turro

Keywords(s): Cancer, Pharmaceuticals

Category(s): Chemicals, Drug Delivery, Life Science, Physical Sciences, Other

Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging

Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI...

Published: 5/1/2018 | Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf

Keywords(s): Biotechnology, Imaging

Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools

First Row Transition Metal Diazadiene Film Growth Precursors

Technology Overview Wayne State University researchers have developed a new class of thermally stable, volatile transition chemical compounds that have desirable properties for the growth of thin films of transition metal-containing materials. These novel film precursors have high potential for use in the growth of thin films by chemical vapor...

Published: 3/12/2018 | Inventor(s): Charles Winter, Thomas Knisley

Keywords(s):

Category(s): Chemicals, Materials, Other, Physical Sciences, Thin films

Vibro-acoustic metamaterial with mass and flexible stem array

WSU researchers have developed a novel device combining the effects of negative effective elastic modulus and negative effective mass, acting as local resonators that can damp out vibrations and sound at multiple frequencies. This class of metamaterials has the superior ability to attenuate sound and have a much greater ability to block dynamic disturbances....

Published: 9/10/2021 | Inventor(s): Md Tofiqul Islam, Golam Newaz, Mohammad Hailat

Keywords(s):

Category(s): Materials, Industrial & Manufacturing, Other, Physical Sciences, Building & Construction

Guidance and Control System for Under Actuated Marine Surface Vessels

WSU researchers have developed a guidance system that yields a faster convergence rate of the ship to its desired trajectory than existing systems. The new algorithm varies the radius in the guidance algorithm exponentially as opposed to linear variations in existing schemes. This was done to prevent the system from over-reacting for small cross track...

Published: 9/10/2021 | Inventor(s): Nabil Chalhoub, Nassim Khaled

Keywords(s):

Category(s): Physical Sciences, Automotive & Transportation, Other, Software

Fuel Injector to Work as an Ionization Sensor and as an Injection Signal Detector in Electronically Controlled Fuel Injection Systems in Diesel and Direct Injection Gasoline Engines

Wayne State researchers have created an invention which uses one element in the engine, the fuel injector, to perform four tasks, injecting fuel, acting as an injection pulse detector, operating as a fuel injector malfunction detector and working as an ion sensor without modifying the fuel injector. Internal combustion engine control has become more...

Published: 12/5/2022 | Inventor(s): Fadi Estefanous

Keywords(s):

Category(s): Electronics, Automotive & Transportation, Physical Sciences, Powertrain, Sensors, Other

Ultra-Sensitive Piezoresistive Accelerometer Based on Decoupled Piezoresistors

Ultra-sensitive piezoresistive accelerometer that has advantages over traditional piezoresistive accelerometers in both the sensitivity and minimum detectable acceleration.Wayne State University researchers have developed an ultra-sensitive piezoresistive accelerometer that has advantages over traditional piezoresistive accelerometers in both the sensitivity...

Published: 5/19/2017 | Inventor(s): Yong Xu, Zhou Wang

Keywords(s): Military, Sound_monitoring

Category(s): Electronics, Other, Physical Sciences, Sensors

Development of TiO2 Anatase Thin Films Grown by Pulsed DC Magnetron Reactive Sputtering for Device Applications

WSU researchers have developed a novel procedure for creating Titanium Dioxide (TiO2) thin films using anatase material. Procedure uses TiO2 thin film with single phase a textured material and reproducible with different thickness on amorphous and crystalline substrates. Anatase is attracting much interest for its unique properties and has valuable...

Published: 9/10/2021 | Inventor(s): Ibrahim Al-Houmoudi, Golam Newaz, Gregory Auner, Ratna Naik

Keywords(s): Anti Reflection, Sensors

Category(s): Chemicals, Materials, Thin films, Physical Sciences, Sensors, Industrial & Manufacturing, Other

Imaging Tandem Mass Spectrometry: Reduction to Practice

Currently, tandem mass spectrometry is typically performed by selecting a single mass peak in a time of flight or quadrupole mass spectrometer, which is then fragmented through collision, after which the products are mass-selected in a quadrupole or similar secondary mass spectrometer. A Wayne State University researcher has developed an alternative...

Published: 6/30/2025 | Inventor(s): Arthur Suits, Myung Kim, Brian Leskiw

Keywords(s): Diagnostics, Instrumentation, Method

Category(s): Instrumentation, Physical Sciences, Spectroscopy, Imaging, Other

Volatile Thermally Stable Transition Metal Precursors for Thin Film Growth

Wayne State researchers have developed a new class of thermally stable, volatile transition chemical compounds that have desirable properties for the growth of thin films of transition metal-containing materials by atomic layer deposition and chemical vapor deposition.Commercial Applications ? Microelectronic devices o Automotive applications...

Published: 5/19/2017 | Inventor(s): Charles Winter, Mahesh Karunrathne

Keywords(s): Batteries, Coatings, Electronics

Category(s): Materials, Chemicals, Other, Physical Sciences, Thin films

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