Search Results - Research tools




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Polyclonal and Monoclonal Antibodies to TPH1 and TPH2
This technology is a set of antibodies that is used with immunohistochemistry techniques to differentiate between tryptophan hydroxylase 1 and 2, enabling scientists to study how the two enzymes are differentially regulated. Background & Unmet Need: The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode enzymes in serotonin biosynthesis. ...
Published: 12/4/2019   |   Inventor(s): Donald Kuhn
Keywords(s): Antibody, Assay, Immunoassay
Category(s): Life Science, Research tools, Biological materials, Antibodies
EL4-E2 Cell Line
This technology is a targeted anti-HER2 cell line that can be used as a research tool to develop HER2‑based vaccines for the treatment of aggressive breast cancer. Background & Unmet Need: The human epidermal growth factor 2 (HER2) is overexpressed in approximately 20-30% of all breast cancers and is associated with more aggressive and proliferative...
Published: 9/17/2019   |   Inventor(s): Wei-Zen Wei
Keywords(s): Breast Cancer
Category(s): Cell lines, Life Science, Research tools, Biological materials
Transgenic Mice Carrying Wild Type Human Her-2 Under the Whey Acidic Promoter
This technology is an animal model designed to help pharmaceutical and biotechnology industries develop Her-2 based vaccines or immunotherapeutic agents. Background & Unmet Need: Her-2 positive breast cancer is a breast cancer that is positive for a protein called human epidermal growth factor receptor 2 (Her-2).  Presence of Her-2 promotes the growth...
Published: 9/17/2019   |   Inventor(s): Wei-Zen Wei, Ye-Shih Ho, Marie Piechocki
Keywords(s): Animal Model, Breast Cancer, Research Tool
Category(s): Animal models, Life Science, Research tools
Tx2 metal-binding tag for purification and identification of recombinant proteins
Tx2 Metal-Binding Tag for Purification and Identification of Recombinant Proteins  WSU Tech#: 11-1058Technology Summary: The technology is a new method of protein purification similar to the principles behind that of a histidine and Ni column system.  The new technology uses a different amino acid sequence for generating a metal-binding cluster:T: “H...
Published: 9/17/2019   |   Inventor(s): Jian-Ping Jin
Keywords(s): Assay, Biotechnology, Process, Protein, Reagents, Tool
Category(s): Life Science, Research tools, Protein/peptides
A Gene Knockout Mouse Model to Study Lung Disease and a Lung Disease Drug Target
Our researchers have created a gene knockout mouse model that lacks the cytochrome c oxidase subunit IV-2 in order to study the gene’s effects on controlling asthma. Background & Unmeet Need: Asthma is an inflammatory disease of the airways that affects 155 million people of all ages worldwide.  Cytochome c oxidase (CcO) is a multi-subunit enzyme located...
Published: 9/17/2019   |   Inventor(s): Maik Huttemann, Lawrence Grossman, David Bassett
Keywords(s): Asthma, Disease, Drug Target, Gene, Knock-out, Lung, Mouse Model
Category(s): Animal models, Biological materials, Life Science, Research tools, Protein/peptides
Multisystemic therapy-Health Care (MST-HC)
This invention is an evidence-based behavioral treatment developed for monitoring youths with chronic health conditions and a history of poor illness management. Background & Unmet Need: The main technology for monitoring chronically ill patients with poor adherence is disease management programs.  While these programs may be helpful, they are focused...
Published: 11/28/2017   |   Inventor(s): Deborah Ellis, Sylvie Naar-King
Keywords(s): Asthma, Diabetes, Patient Monitoring
Category(s): Life Science, Research tools, Other
An in vivo QQ-systemic protein delivery technology and applications
BackgroundThis invention contains a new composition of our researchers’ previously patented QQ-protein delivery technology and the in vivo applications of this protein delivery technology via systemic administered proteins for cancer diagnosis and therapy.  Many proteins and peptides are used as highly specific and effective therapeutic agents.  Their...
Published: 8/3/2017   |   Inventor(s): Jianjun Wang, Qianqian Li, Quan Jiang, Feng Jiang, Michael Chopp
Keywords(s): Cancer Therapies, Drug Delivery
Category(s): Diagnostics, Drug Delivery, Life Science, Oncology, Research tools, Therapeutics
A protein-induced In situ cell-conversion technology and applications
BackgroundCell reprogramming and trans-differentiation are techniques that convert somatic cells of individuals into either stem cells, including embryonic and adult stem cells (reprogramming) or the other type of somatic cells (trans-differentiation).  These techniques are usually performed in the cell culture settings using viral gene delivery and...
Published: 8/3/2017   |   Inventor(s): Jianjun Wang, Qianqian Li, Feng Jiang, Michael Chopp, Guojun Wu
Keywords(s): Cancer Therapies, Drug Delivery
Category(s): Drug Delivery, Life Science, Research tools
Inhibitors of the ubiquitin E3 ligase BCA2 as anti-cancer therapeutic agents
Background:Breast cancer associated protein 2 (BCA2) is a ubiquitin E3 ligase found in invasive breast cancer.  Studies have shown that by decreasing its activity, breast cancer cell growth and invasiveness are diminished.  Targeting this ligase and inhibiting its activity could play a role in treatment of breast cancer.  A molecular approach to inhibiting...
Published: 8/3/2017   |   Inventor(s): Angelika Burger, Andrew Westwell
Keywords(s): Analog or Analogue, Breast Cancer, Cancer, Disease, Drug Target, Enzyme
Category(s): Diseases, Oncology, Therapeutics, Life Science, Research tools
Generation of gp78 null mice
Generation of gp78 null mice WSU Tech#: 15-1291 Technology: Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis,...
Published: 5/19/2017   |   Inventor(s): Avraham Raz, Andrei Golovko
Keywords(s):  
Category(s): Animal models, Biology, Biomedical, Biotechnology, Drug Delivery, Drug Discovery, Drug Screening, Genomics/Genetics, Life Science, Oncology, Research tools
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