Search Results - aloke+dutta

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CNS Compounds Specific for the Monoamine Transporter Systems

This invention includes novel compounds that have neuropharmacological activity with the dopamine receptor and the method of using them to treat central nervous system disorders. Background & Unmet Need: The dopamine transporter (DAT) plays an important role in processes of the central nervous system. In cocaine addiction, binding of cocaine...

Published: 2/8/2022 | Inventor(s): Aloke Dutta

Keywords(s): Addiction Treatment, Antidepressants, Neuroscience, Parkinson's

Category(s): Therapeutics, Life Science, Diseases, Neurological disorders

Novel Hybrid Series of Compound Derived from 2-Aminotetralin and Piperazine Based Derivatives: Characterization for D1, D2, D3, D4 and other Serotonin Receptor Subtypes Binding

A series of compounds derived from 2-aminotetralin and piperazine fragments have been synthesized, which exhibit high CNS activity in vivo and in vitro. Some of the selected lead compounds have exhibited potent in vivo activity in a Parkinson’s disease animal model with long extended duration of action. In particular, these compounds show high...

Published: 11/19/2021 | Inventor(s): Aloke Dutta, Xiang-Shu Fei

Keywords(s):

Category(s): Therapeutics, Diseases, Life Science, Small molecule, Neurological disorders