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Fc-folate conjugate for the treatment of triple negative breast cancer

Approximately 13% of women in the United States will develop breast cancer according to the American Cancer Society. That makes breast cancer the second leading cause of cancer death in women right behind lung cancer. Triple negative breast cancer (TNBC) represents about 10 – 20% of all breast cancers. Triple negative refers to cancer cells...

Published: 10/31/2024 | Inventor(s): Cecilia Speyer

Keywords(s): Anti-cancer, Breast Cancer, Cancer, Cancer Therapies

Category(s): Antibodies, Assays, Biology, Biomedical, Chemical Processing/Synthesis, Diseases, Drug Delivery, Life Science, Oncology, Protein/peptides, Receptors/targets, Small molecule, Therapeutics

Ultra-Specific and Ultra-Sensitive Platform for Highly-Reliable and High-Precision SARS-CoV-2 Detection

Background:The technology described is based on the use of two unique sets of detection molecules that are specific to a protein contained in the viral shell of SARS CoV-2 and Covid-19 that is unique from other known common cold causing coronaviruses. The proposed system uses two different fluorescent probes for two different regions of the viral shell...

Published: 10/26/2023 | Inventor(s): Rodrigo Fernandez-Valdivia

Keywords(s): Coronavirus, COVID-19, Diagnostic, Virus

Category(s): Diagnostic, Biomedical, Medical, Diseases, Infectious disease

Topical treatment with TGFbeta3 to facilitate skin and corneal wound healing in diabetic patients

Background: Diabetes affects approximately 170 million people worldwide, including 20.8 million in the USA, and by 2030 these numbers are projected to double. Diabetics often experience slow or limited wound healing. Slow wound healing allows longer time for the development of infections and can contribute to the formation of bed sores and ulcers....

Published: 9/16/2019 | Inventor(s): Fu-Shin Yu

Keywords(s): Diabetes

Category(s): Medical, Biologicals, Biomedical, Drug Discovery, Metabolic disorders, Protein/peptides, Therapeutics, Life Science

Generation of gp78 null mice

Generation of gp78 null mice WSU Tech#: 15-1291 Technology: Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis,...

Published: 11/22/2021 | Inventor(s): Avraham Raz, Andrei Golovko

Keywords(s):

Category(s): Animal models, Biology, Biomedical, Biotechnology, Drug Delivery, Drug Discovery, Drug Screening, Genomics/Genetics, Life Science, Oncology, Research tools

Secure Aliquoting Machine (SAM): An error free automated system for labeling and aliquoting clinical samples

Safe, Simple, Speedy Sample Transferring System (4STS) WSU Tech#: 14-1202 Technology Summary: The Vacutainer blood collection tubes (BD) have been optimized for various tests. One of the innovations in the Vacutainer collection tubes is the addition of a special gel to the tube that allows the separation of serum or plasma from cellular component...

Published: 9/12/2019 | Inventor(s): Hossein Salimnia

Keywords(s):

Category(s): Medical, Biomedical, Devices, Medical Devices

Easy Cell Block Device for Cytopathology and Surgical Pathology Specimens

Cell Block Device for Cytopathology and Surgical Pathology Specimens WSU Tech#: 13-1174 Technology Summary: Preparation of cell blocks is indicated from swaps or collected fluids where cells or small tissue fragments are examined. Veterinary sciences and many research labs also need good methodology to prepare high quality cell blocks with...

Published: 3/3/2020 | Inventor(s): Vinod Shidham, Anjani Shidham

Keywords(s):

Category(s): Medical, Biomedical, Diagnostic, Microscopy

GENERATION OF 5-FLUOROURACIL + OXALIPLATIN RESISTANT COLON CANCER CELLS: A TOOL TO STUDY CANCER RECURRENCE AND DRUG RESISTANCE

Generation of 5-Fluorouracil + Oxaliplatin Resistant Colon Cancer Cells WSU Tech#: 13-1154 Technology Summary: A significant obstacle for the successful management of patients with colorectal cancer (CRC) is intrinsic drug resistance or, in patients who respond to chemotherapy, acquired drug resistance. Drug resistance can occur through a variety...

Published: 11/19/2021 | Inventor(s): Adhip Majumdar, Yingjie Yu

Keywords(s):

Category(s): Biomedical, Biotechnology, Cell lines, Characterization, Drug Discovery, Oncology, Research tools

Vaginal microbiome snapshot (VMS)

Vaginal Microbiome Sanpshot; a Method for Diagnosing Bacterial Vaginosis and Other Vaginal Disorders WSU Tech#: 13-1141 Technology Summary: Bacterial vaginosis (BV) is a disease of the vagina caused by an imbalance of naturally occurring bacterial flora and is often confused with yeast infection (candidiasis) or infection with Trichomonas vaginalis...

Published: 10/27/2020 | Inventor(s): Robert Akins, Jack Sobel

Keywords(s):

Category(s): Assays, Biomedical, Diagnostic, Diagnostics, Infectious disease

Level of Galectin-3 protein in human blood improves PSA test results

Level of Galectin-3 Protein in Human Blood Improves PSA Test Results WSU Tech#: 13-1133 Technology Summary: For determining prostate cancer aggressiveness, PSA alone is not reliable, as it gives a high number of false positive and false negative results. There are about 25,000 publications on other markers in addition to PSA and as of yet, none...

Published: 3/3/2020 | Inventor(s): Avraham Raz, Vitaly Balan, Elisabeth Heath, Lance Heilbrun

Keywords(s):

Category(s): Medical, Biomedical, Diagnostics, Oncology

Long non-protein-coding RNA molecules as therapeutics for epilepsy.

Long Non-Coding RNA Molecules as Therapeutics for Epilepsy WSU Tech#: 12-1089 Technology Summary: Long Non-coding RNA (lncRNA) were first described in 2002 from mouse, making this a relatively new technology. lncRNA transcripts far exceed the number of protein coding mRNAs in the mammalian transcriptome, but in lower copy numbers. Inventors...

Published: 10/5/2023 | Inventor(s): Jeffrey Loeb, Leonard Lipovich

Keywords(s):

Category(s): Medical, Bioinformatics, Biomedical, Biotechnology, Diagnostic, Diagnostics, Drug Discovery, Pharmaceuticals, Therapeutics