Search Results - cell+lines

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Microfluidic platforms for live-cell imaging and bio/pathomimetic tissue models

Background:Methodologies to image and quantify tissue models using high-content analysis (HCI) and functional analyses of 3D avatars are needed as such avatars better recapitulate the phenotype of pathobiological processes and better predict efficacy of, and resistance to, a wide variety of therapies. Furthermore, changes in morphometry, viability,...

Published: 2/14/2022 | Inventor(s): Bonnie Sloane, Kamiar Moin, Kyungmin Ji, Kingsley Osuala, Yong Xu, Hongen Tu

Keywords(s):

Category(s): Specialty compounds, Research tools, Oncology, Microfluidics, Life Science, Instrumentation, Imaging, Diseases, Devices, Cell lines

EL4-E2 Cell Line

This technology is a targeted anti-HER2 cell line that can be used as a research tool to develop HER2‑based vaccines for the treatment of aggressive breast cancer. Background & Unmet Need: The human epidermal growth factor 2 (HER2) is overexpressed in approximately 20-30% of all breast cancers and is associated with more aggressive and proliferative...

Published: 3/24/2022 | Inventor(s): Wei-Zen Wei

Keywords(s): Breast Cancer

Category(s): Cell lines, Life Science, Research tools, Biological materials

GENERATION OF 5-FLUOROURACIL + OXALIPLATIN RESISTANT COLON CANCER CELLS: A TOOL TO STUDY CANCER RECURRENCE AND DRUG RESISTANCE

Generation of 5-Fluorouracil + Oxaliplatin Resistant Colon Cancer Cells WSU Tech#: 13-1154 Technology Summary: A significant obstacle for the successful management of patients with colorectal cancer (CRC) is intrinsic drug resistance or, in patients who respond to chemotherapy, acquired drug resistance. Drug resistance can occur through a variety...

Published: 11/19/2021 | Inventor(s): Adhip Majumdar, Yingjie Yu

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Category(s): Biomedical, Biotechnology, Cell lines, Characterization, Drug Discovery, Oncology, Research tools

CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines

CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines WSU Tech#: 15-1256 Technology Summary: CJ4.1A and CJ4.3C are rat conjunctival epithelial cell lines. The cell lines were developed to investigate antigen translocation across a mucosal barrier. Conjuctival epithelial cells from Fischer 344 rats were immortalized with pSV3(neo) resulting in...

Published: 2/18/2022 | Inventor(s): Nancy O'sullivan, Alfred Baylor Iii, Paul Montgomery

Keywords(s):

Category(s): Cell lines, Life Science, Research tools

Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors

Background: Often referred to as the crucial "drug discovery tool", cell based technology is one of the most significant sectors of pharmaceutical research and development. Of particular importance has been the development of information-rich cellular assays that determine drug candidate efficacy and safety (target identification, validation...

Published: 4/17/2022 | Inventor(s): Leon Carlock, Maria Cypher

Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics

Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines, Oncology