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Co-polymer Stabilizers for Pressured Metered Dose Inhalers (pMDIs)

A series of novel co polymer surfactants with the general structure LAmEOnLAm were developed along with a Colloidal Probe Microscopy (CPM) method to optimize the surfactant composition using adhesion forces to improve stabilization of drug dispersions. This expands the range of biomolecules and micronized drug particles that can be formulated with pMDIs....

Published: 11/11/2021 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Assay, Asthma, Compound, Device, Drug Delivery, Formulation, Instrumentation, Method, Pharmaceuticals, Process, Therapeutics

Category(s): Chemicals, Drug Delivery, Pharmaceuticals, Instrumentation, Materials

Ruthenium-based caging of nitrile-containing enzyme inhibitors

Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the pathophysiology...

Published: 10/27/2023 | Inventor(s): Jeremy Kodanko, Claudia Turro

Keywords(s): Cancer, Pharmaceuticals

Category(s): Chemicals, Drug Delivery, Life Science, Physical Sciences, Other

Next Generation MRI Contrast Imaging Agent

WSU has developed a new class of contrast agents that are effective at ultra-high field strengths (>3 tesla) in magnetic resonance imaging (MRI) where current clinical agents severely decline in effectiveness. Our new agents are based on the metal Eu(II) which is novel compared to current agents that are based on Gd(III). The difference between the...

Published: 11/8/2021 | Inventor(s): Matthew Allen, Nipuni Gamage, Yujiang Mei, Joel Garcia, Jeremiah Moore

Keywords(s): Compound, Diagnostic, Imaging, MRI, Positive Imaging Agent

Category(s): Imaging, Chemicals, Life Science, MRI, Physical Sciences, Specialty compounds

Solid Zn-base Catalysts for Simultaneous Transesterification and Esterification

Description: WSU researchers have developed a series of novel heterogeneous catalysts for simultaneous transesterifrication and esterifrication of fats and oils that can be used in the production of biodiesel. These catalysts are solids, a mixture of zinc oxide and other metal oxides species which provide the potential to convert all kinds of oil feedstocks...

Published: 3/3/2020 | Inventor(s): Shuli Yan, Ka Yuen Simon Ng, Steven Salley

Keywords(s): Biodiesel

Category(s): Chemicals, Catalysts, Energy & Environment, Physical Sciences, Renewable Fuels

Dispersion-optimized Silicon nanoparticle (SiNP)/Graphene composite anode for high performance Lithium ion battery (LIB)

WSU researchers have invented a novel method to produce dispersion-optimized SiNP within a conducting Graphene matrix forming a standalone composite anode material. The method creates small clusters to lone particle distributions maximizing the nanomaterial properties of SiNP yielding anodes with improved capacity retention and rate performance. It...

Published: 8/26/2021 | Inventor(s): Rhet C De Guzman, Ka Yuen Simon Ng, Steven Salley

Keywords(s):

Category(s): Chemicals, Materials, Energy & Environment, Energy Storage/Battery, Nanomaterials, Physical Sciences

First Row Transition Metal Diazadiene Film Growth Precursors

Technology Overview Wayne State University researchers have developed a new class of thermally stable, volatile transition chemical compounds that have desirable properties for the growth of thin films of transition metal-containing materials. These novel film precursors have high potential for use in the growth of thin films by chemical vapor...

Published: 3/12/2018 | Inventor(s): Charles Winter, Thomas Knisley

Keywords(s):

Category(s): Chemicals, Materials, Other, Physical Sciences, Thin films

Combined Homogeneous and Heterogeneous Catalytic Transesterification Process for Biodiesel Production

WSU researchers developed a combined heterogeneous and homogeneous catalyst that reduces overall production costs, expands feedstock options, and enables large volume production in a continuous process as compared to traditional homogeneous biodiesel catalysts. This unique catalytic transesterification process works better with ethanol compared to...

Published: 2/7/2022 | Inventor(s): Manhoe Kim, Steven Salley, Ka Yuen Simon Ng

Keywords(s):

Category(s): Catalysts, Chemicals, Physical Sciences, Renewable Fuels, Energy & Environment

Biologically active ATP-Analogs for tagging phosphoproteins

A novel Photo Cross Linking Assay (PCLA) for targeting protein phosphorylation Protein phosphorylation catalyzed by kinases and phosphatases act at critical control points that regulates many cellular processes. This central role makes them an attractive target for identifying largely untapped and important biomarkers for disease diagnostics. Understanding...

Published: 11/11/2021 | Inventor(s): Mary Pflum

Keywords(s):

Category(s): Chemicals, Life Science, Research tools, Assays, Reagents

Development of TiO2 Anatase Thin Films Grown by Pulsed DC Magnetron Reactive Sputtering for Device Applications

WSU researchers have developed a novel procedure for creating Titanium Dioxide (TiO2) thin films using anatase material. Procedure uses TiO2 thin film with single phase a textured material and reproducible with different thickness on amorphous and crystalline substrates. Anatase is attracting much interest for its unique properties and has valuable...

Published: 9/10/2021 | Inventor(s): Ibrahim Al-Houmoudi, Golam Newaz, Gregory Auner, Ratna Naik

Keywords(s): Anti Reflection, Sensors

Category(s): Chemicals, Materials, Thin films, Physical Sciences, Sensors, Industrial & Manufacturing, Other

Effect of Natural and Synthetic Antioxidants on the Oxidative Stability of Biodiesel

Researchers at WSU’s National Biofuels Energy Laboratory have identified antioxidant additives for biodiesel fuel made from a variety of feedstock that provide advantages to current technologies. A significant problem associated with the commercial acceptance of biodiesel fuel is poor oxidative stability. The presence of high levels of unsaturated fatty...

Published: 3/3/2020 | Inventor(s): Ka Yuen Simon Ng, Steven Salley, Haiying Tang

Keywords(s): Biodiesel

Category(s): Renewable Fuels, Physical Sciences, Energy & Environment, Chemicals, Specialty compounds

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