Search Results - diseases




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A method to induce ferroptosis and to downregulate androgen receptor/androgen receptor splice variant in prostate cancer cells
Prostate cancer (PCa) effects approximately three million men in the United States every year. About 10-20% of the cases of prostate cancer are castrate-resistant prostate cancer (CRPC). This form of PCa is highly resistant to what Is known as androgen depletion therapy and is often fatal. All types of PCa are sensitive to androgen receptor signaling...
Published: 11/19/2020   |   Inventor(s): Zhihui Qin, Liping Xu
Keywords(s): Anti-cancer, Cancer, Cancer Therapies, Drug Delivery, Drug Target, Prostate Cancer
Category(s): Medical, Diseases, Drug Discovery, Pharmaceuticals, Oncology
Fc-folate conjugate for the treatment of triple negative breast cancer
Approximately 13% of women in the United States will develop breast cancer according to the American Cancer Society. That makes breast cancer the second leading cause of cancer death in women right behind lung cancer. Triple negative breast cancer (TNBC) represents about 10 – 20% of all breast cancers. Triple negative refers to cancer cells...
Published: 11/19/2020   |   Inventor(s): Cecilia Speyer
Keywords(s): Anti-cancer, Breast Cancer, Cancer, Cancer Therapies
Category(s): Antibodies, Assays, Biology, Biomedical, Chemical Processing/Synthesis, Diseases, Drug Delivery, Life Science, Oncology, Protein/peptides, Receptors/targets, Small molecule, Therapeutics
Ultra-Specific and Ultra-Sensitive Platform for Highly-Reliable and High-Precision SARS-CoV-2 Detection
Background:The technology described is based on the use of two unique sets of detection molecules that are specific to a protein contained in the viral shell of SARS CoV-2 and Covid-19 that is unique from other known common cold causing coronaviruses. The proposed system uses two different fluorescent probes for two different regions of the viral shell...
Published: 5/26/2020   |   Inventor(s): Rodrigo Fernandez-Valdivia
Keywords(s): Coronavirus, COVID-19, Diagnostic, Virus
Category(s): Diagnostic, Biomedical, Medical, Diseases, Infectious disease
Microfluidic platforms for live-cell imaging and bio/pathomimetic tissue models
Background:Methodologies to image and quantify tissue models using high-content analysis (HCI) and functional analyses of 3D avatars are needed as such avatars better recapitulate the phenotype of pathobiological processes and better predict efficacy of, and resistance to, a wide variety of therapies. Furthermore, changes in morphometry, viability,...
Published: 4/6/2020   |   Inventor(s): Bonnie Sloane, Kamiar Moin, Kyungmin Ji, Kingsley Osuala, Yong Xu, Hongen Tu
Keywords(s):  
Category(s): Specialty compounds, Research tools, Oncology, Microfluidics, Life Science, Instrumentation, Imaging, Diseases, Devices, Cell lines
SALT-FORMULATED VALPROATE AS A TOPICAL ANTI-FUNGAL TREATMENT
In 2018, the global antifungal drugs market size was valued at USD 11.6 billion. Generally speaking, 54.3% of sales are prescription and 45.7% is over-the counter OTC/Alternative. It is anticipated that the OTC/Alternative portion of the global antifungal market will continue to grow. Science is indicating that both the number of systemic infections...
Published: 4/6/2020   |   Inventor(s): Miriam Greenberg, Rania Deranieh
Keywords(s):  
Category(s): Diseases, Infectious disease, Life Science, Small molecule, Pharmaceuticals
Using nanotechnology to target aggressive cancers with a novel small molecule inhibitor of the DNA damage tolerance pathway
Background: Nanotechnology is emerging as a promising tool to target cancer cells. Gold nanoparticles (GNPs) are preferentially taken up by cancer cells when injected into the blood stream and their safety has been demonstrated in human clinical trials. WSU researchers have designed a unique nanoparticle conjugate that combines a GNP with a small molecule...
Published: 8/15/2017   |   Inventor(s): Malathy Shekhar, Guangzhao Mao, Yanhua Zhang
Keywords(s):  
Category(s): Life Science, Oncology, Small molecule, Receptors/targets, Nano-based, Drug Delivery, Therapeutics, Diseases
Inhibitors of the ubiquitin E3 ligase BCA2 as anti-cancer therapeutic agents
Background:Breast cancer associated protein 2 (BCA2) is a ubiquitin E3 ligase found in invasive breast cancer. Studies have shown that by decreasing its activity, breast cancer cell growth and invasiveness are diminished. Targeting this ligase and inhibiting its activity could play a role in treatment of breast cancer. A molecular approach to inhibiting...
Published: 8/3/2017   |   Inventor(s): Angelika Burger, Andrew Westwell
Keywords(s): Analog or Analogue, Breast Cancer, Cancer, Disease, Drug Target, Enzyme
Category(s): Diseases, Oncology, Therapeutics, Life Science, Research tools
Anti-Cancer Activity of a 2,5-Substituted Pyrimidine
This technology is a novel class of compounds that induce apoptosis in cancerous cells. BackgroundARR molecules (adamantyl-substituted retinoid-related) are a unique class of compounds which have been found to induce apoptosis, or cell death, in a large number of tumor types. SHP plays a role in cellular proliferation. Molecules that Interfere with...
Published: 8/3/2017   |   Inventor(s): Joseph Fontana, Ramzi Mohammad, Lulu Farhana, Amro Aboukameel, Marcia Dawson, Zebin Xia
Keywords(s): Analog or Analogue, Anti-cancer
Category(s): Life Science, Oncology, Therapeutics, Diseases
Novel Anti-Cancer Therapeutic Strategy to Overcome Cancer Resistance and to Enable Tailoring Treatment
This technology is a gene therapy construct based on modified programmed-cell-death genes involved in intracellular apoptosis. Bypassing the main treatment-resistant mechanisms of cancer offers a new direction, away from broad-spectrum treatments, towards individualized therapies for cancer treatment that carry fewer side-effects. Background &...
Published: 8/3/2017   |   Inventor(s): Karli Rosner
Keywords(s): Anti-cancer, Cancer, Disease, Gene, Melanoma, Target, Therapeutics
Category(s): Life Science, Therapeutics, Diseases, Oncology, Biologicals, Genes
Modified Ectodomain of Human EGFR as a Potential Anticancer Agent
Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion of...
Published: 8/3/2017   |   Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu
Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics
Category(s): Life Science, Biologicals, Diseases, Oncology
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