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Discovery of Well Defined Sulfated Glycopolymers as Specific Heparanase Inhibitors for Cancer Therapeutics

The remodeling of the extracellular matrix has been shown to be highly upregulated in cancer and inflammation and is critically linked to the processes of invasion and metastasis. The finding that heparanase is elevated in a wide variety of tumor types and is subsequently linked to the development of pathological processes has led to an explosion of...

Published: 12/2/2020 | Inventor(s): Hein Nguyen, Ravi Loka, Eric Sletten, Israel Vlodavsky

Keywords(s): Cancer, Cancer Therapies, Pharmaceuticals, Therapeutics

Category(s): Life Science, Oncology, Pharmaceuticals, Therapeutics

Identification of Galeterone's mechanism of action leading to novel treatment therapies for castrate resistant prostate cancer (CRPC)

Castration-Resistant Prostate Cancer (CRPC) or Hormone Refractory Prostate Cancer (HRPC), is a type of prostate cancer that typically recurs after administering androgen deprivation therapy (ADT). The need for effective therapies for these difficult to treat cancers is gaining prominence in the prostate cancer market. The global CRPC market is poised...

Published: 11/19/2020 | Inventor(s): Qingping Dou, Huanjie Yang, Elisabeth Heath

Keywords(s):

Category(s): Life Science, Oncology, Pharmaceuticals, Receptors/targets, Process/Procedure, Small molecule, Therapeutics

Fc-folate conjugate for the treatment of triple negative breast cancer

Approximately 13% of women in the United States will develop breast cancer according to the American Cancer Society. That makes breast cancer the second leading cause of cancer death in women right behind lung cancer. Triple negative breast cancer (TNBC) represents about 10 – 20% of all breast cancers. Triple negative refers to cancer cells...

Published: 10/31/2024 | Inventor(s): Cecilia Speyer

Keywords(s): Anti-cancer, Breast Cancer, Cancer, Cancer Therapies

Category(s): Antibodies, Assays, Biology, Biomedical, Chemical Processing/Synthesis, Diseases, Drug Delivery, Life Science, Oncology, Protein/peptides, Receptors/targets, Small molecule, Therapeutics

Disulfide by Design 2.0: A web-based tool for disulfide engineering in proteins

Background:Immunoinformatics employs a computer-driven approach to identifying fragments of the target pathogen that would provide a suitable vaccine, avoiding potential safety concerns from the more traditional approach of using whole pathogens. Immunoinformatics now plays a crucial role in vaccine design, immunodiagnostic development, and antibody...

Published: 4/18/2022 | Inventor(s): Alan Dombkowski, Douglas Craig

Keywords(s): Coronavirus, COVID-19

Category(s): Life Science, Software, Simulation & Modeling, Research tools, Computer Software, Protein/peptides

Microfluidic platforms for live-cell imaging and bio/pathomimetic tissue models

Background:Methodologies to image and quantify tissue models using high-content analysis (HCI) and functional analyses of 3D avatars are needed as such avatars better recapitulate the phenotype of pathobiological processes and better predict efficacy of, and resistance to, a wide variety of therapies. Furthermore, changes in morphometry, viability,...

Published: 2/14/2022 | Inventor(s): Bonnie Sloane, Kamiar Moin, Kyungmin Ji, Kingsley Osuala, Yong Xu, Hongen Tu

Keywords(s):

Category(s): Specialty compounds, Research tools, Oncology, Microfluidics, Life Science, Instrumentation, Imaging, Diseases, Devices, Cell lines

SALT-FORMULATED VALPROATE AS A TOPICAL ANTI-FUNGAL TREATMENT

In 2018, the global antifungal drugs market size was valued at USD 11.6 billion. Generally speaking, 54.3% of sales are prescription and 45.7% is over-the counter OTC/Alternative. It is anticipated that the OTC/Alternative portion of the global antifungal market will continue to grow. Science is indicating that both the number of systemic infections...

Published: 1/21/2022 | Inventor(s): Miriam Greenberg, Rania Deranieh

Keywords(s):

Category(s): Diseases, Infectious disease, Life Science, Small molecule, Pharmaceuticals

Polyclonal and Monoclonal Antibodies to TPH1 and TPH2

This technology is a set of antibodies that is used with immunohistochemistry techniques to differentiate between tryptophan hydroxylase 1 and 2, enabling scientists to study how the two enzymes are differentially regulated. Background & Unmet Need: The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode enzymes in serotonin biosynthesis....

Published: 11/19/2021 | Inventor(s): Donald Kuhn

Keywords(s): Antibody, Assay, Immunoassay

Category(s): Life Science, Research tools, Biological materials, Antibodies

Drugs that disrupt interactions between ELK1 and the androgen receptor to suppress growth of both early stage and castration resistant prostate cancer

Background:Prostate cancer is the second-most commonly diagnosed cancer among men and the fifth most common cause of male cancer death worldwide. Although tumors are often initially sensitive to medical or surgical therapies that decrease levels of testosterone, continued disease progression generally represents a transition to the lethal variant. In...

Published: 10/22/2019 | Inventor(s): Manohar Ratnam, Rayna Rosati, Mugdha Patki

Keywords(s):

Category(s): Life Science, Therapeutics, Oncology, Drug Discovery, Pharmaceuticals

EL4-E2 Cell Line

This technology is a targeted anti-HER2 cell line that can be used as a research tool to develop HER2‑based vaccines for the treatment of aggressive breast cancer. Background & Unmet Need: The human epidermal growth factor 2 (HER2) is overexpressed in approximately 20-30% of all breast cancers and is associated with more aggressive and proliferative...

Published: 3/24/2022 | Inventor(s): Wei-Zen Wei

Keywords(s): Breast Cancer

Category(s): Cell lines, Life Science, Research tools, Biological materials

Transgenic Mice Carrying Wild Type Human Her-2 Under the Whey Acidic Promoter

This technology is an animal model designed to help pharmaceutical and biotechnology industries develop Her-2 based vaccines or immunotherapeutic agents. Background & Unmet Need: Her-2 positive breast cancer is a breast cancer that is positive for a protein called human epidermal growth factor receptor 2 (Her-2). Presence of Her-2 promotes...

Published: 9/9/2024 | Inventor(s): Wei-Zen Wei, Ye-Shih Ho, Marie Piechocki

Keywords(s): Animal Model, Breast Cancer, Research Tool

Category(s): Animal models, Life Science, Research tools

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