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A series of farnesol and geranylgeraniol analogs that block the prenylation of proteins in cells. The diphosphate derivatives of these compounds are potent inhibitors of protein prenyltransferases in vitro. One allylfarnesol compound specifically inhibits the farnesylation of proteins and one allylgeranylgeraniol compound specifically inhibits the...

Published: 5/18/2010 | Inventor(s): Richard Gibbs

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Category(s): Therapeutics, Life Science, Small molecule