Search Results - small molecule




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Using Nanotechnology to Target Aggressive Cancers
Background: Nanotechnology is emerging as a promising tool to target cancer cells. Gold nanoparticles (GNPs) are preferentially taken up by cancer cells when injected into the blood stream and their safety has been demonstrated in human clinical trials. WSU researchers have designed a unique nanoparticle conjugate that combines a GNP with a small m...
Published: 8/15/2017   |   Inventor(s): Malathy Shekhar, Guangzhao Mao, Yanhua Zhang
Keywords(s):  
Category(s): Life Science, Oncology, Small molecule, Receptors/targets, Nano-based, Drug Delivery, Therapeutics, Diseases
A method to identify patients at risk for subsequent stillbirth in the third trimester
A Method to Identify and Treat Patients at Risk for Stillbirth in the 3rd Trimester WSU Tech#: 12-1113 Technology Summary: This invention is a method of identifying patients at risk for subsequent stillbirth (only due to placental related disorder) in the third trimester using a maternal blood sample. A blood sample would be obtained at the ...
Published: 5/19/2017   |   Inventor(s): Tinnakorn Chaiworapongsa, Roberto Romero, Sonia Hassan
Keywords(s):  
Category(s): Medical, Diagnostic, Diagnostics, Prenatal, Small molecule, Specialty compounds, Therapeutics
Inhibitors of Matrix Metalloproteinases
Wayne State University researchers and academic collaborators have prepared the first reported mechanism-based inhibitors for matrix metalloproteinases (MMPs). One of the novel compounds (SB-3CT) shows selectivity for the gelatinases (two members of the MMP family), which have been implicated in various pathological conditions including, but n...
Published: 6/22/2010   |   Inventor(s): Shahriar Mobashery, Rafael Fridman
Keywords(s):  
Category(s): Therapeutics, Life Science, Small molecule, Diseases
Novel Prenyl Transferase Inhibitors
A series of farnesol and geranylgeraniol analogs that block the prenylation of proteins in cells. The diphosphate derivatives of these compounds are potent inhibitors of protein prenyltransferases in vitro. One allylfarnesol compound specifically inhibits the farnesylation of proteins and one allylgeranylgeraniol compound specifically inhibits the...
Published: 5/18/2010   |   Inventor(s): Richard Gibbs
Keywords(s):  
Category(s): Therapeutics, Life Science, Small molecule
Tumor Targeting by Small Molecule Therapeutics for a Proton-Coupled Folate Transporter (PCFT)
BackgroundPCFT plays an important role in intestinal folate absorption. The recently cloned proton-coupled folate transporter (PCFT/SLC46A1) is the primary transporter mediating intestinal folate absorption. PCFT displays optimal folate influx activity at acidic pH and recognizes folic acid, reduced folates (e.g. 6S-5-CH3-THF) and the antifolate ...
Published: 5/6/2010   |   Inventor(s): Larry Matherly, Aleem Gangjee
Keywords(s): Analog or Analogue, Breast Cancer, Cancer Therapies, Drug Delivery, Ovarian Cancer, Prostate Cancer
Category(s): Therapeutics, Life Science, Small molecule, Oncology, Diseases
Designer Aminoglycosides
Wayne State University researchers have synthesized a series of novel aminoglycoside antibiotics that have shown enhanced antibacterial activity, low susceptibility to existing resistance mechanisms and low toxicity when compared to currently marketed aminoglycosides. Aminoglycoside antibiotics have been used against a wide variety of bacteria...
Published: 5/6/2010   |   Inventor(s): Shahriar Mobashery, Lakshmi Kotra, Jalal Haddad
Keywords(s): Antibiotics
Category(s): Therapeutics, Life Science, Small molecule, Diseases, Infectious disease
Novel Hybrid Series of Compound Derived from 2-Aminotetralin and Piperazine Based Derivatives: Characterization for D1, D2, D3, D4 and other Serotonin Receptor Subtypes Binding
A series of compounds derived from 2-aminotetralin and piperazine fragments have been synthesized, which exhibit high CNS activity in vivo and in vitro. Some of the selected lead compounds have exhibited potent in vivo activity in a Parkinson?s disease animal model with long extended duration of action. In particular, these compounds show high...
Published: 5/6/2010   |   Inventor(s): Aloke Dutta, Xiang-Shu Fei
Keywords(s):  
Category(s): Therapeutics, Diseases, Life Science, Small molecule, Neurological disorders