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Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging

Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI...

Published: 5/1/2018 | Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf

Keywords(s): Biotechnology, Imaging

Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools

Sub-monolayer detection with surface selective vibrational spectroscopy

This invention describes a new system and method for performing surface-selective spectroscopic detection with high sensitivity and low detection limits particularly in the visible and fingerprint mid-infrared spectral regions. The method offers a substantial improvement, 10-fold or more, over existing techniques. This invention has already been reduced...

Published: 11/11/2021 | Inventor(s): Alexander Benderskii, Igor Stiopkin, Himali Jayathilake

Keywords(s): Device, Instrumentation, Method, Nanotechnology, Optical, Photonic

Category(s): Instrumentation, Spectroscopy, Physical Sciences

Imaging Tandem Mass Spectrometry: Reduction to Practice

Currently, tandem mass spectrometry is typically performed by selecting a single mass peak in a time of flight or quadrupole mass spectrometer, which is then fragmented through collision, after which the products are mass-selected in a quadrupole or similar secondary mass spectrometer. A Wayne State University researcher has developed an alternative...

Published: 5/19/2017 | Inventor(s): Arthur Suits, Myung Kim, Brian Leskiw

Keywords(s): Diagnostics, Instrumentation, Method

Category(s): Instrumentation, Physical Sciences, Spectroscopy, Imaging, Other