Search Results - nanomaterials

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Nanoparticle Method to Stabilize Suspension-Based pMDI HFA Formulations

Novel nanoparticle-based drug compositions and methods that improve and expand therapeutic drug delivery to the lungs through pressurized meter-dose inhalers (pMDIs). A large variety of approaches have been developed at WSU aimed at improving the aerosol characteristics and expanding the range of target species deliverable. These improved formulations...

Published: 11/11/2021 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Asthma, Drug Delivery, Formulation, Nanomaterials, Pharmaceuticals

Category(s): Drug Delivery, Life Science, Nano-based, Therapeutics

Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases

Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC50...

Published: 11/11/2021 | Inventor(s): David Oupicky, Jing Li

Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals

Fabrication Methods for Anti-Reflection Surface on Transparent Materials

Development of a fabrication method that uses optical nanostructures as artificial materials that match refractive indices of a wide range of transparent substrates. The resulting surface is optically transparent and exhibits qualities required to see images and text clearly on an electronic display screen in a wide variety of light conditions. Electronic...

Published: 9/10/2021 | Inventor(s): Yang Zhao, Jinsong Wang

Keywords(s): Anti-reflection, Nanomaterials

Category(s): Materials, Nanomaterials, Physical Sciences

Nanometer-Sized Drug Delivery Devices (Nanoparticles) that Demonstrate High Encapsulation Efficiency and Sustained Release of Water-Soluble Drugs and their Preparation

This technology is a nano‑meter size drug delivery system that is capable of encapsulating water‑soluble drugs with high efficiency, allowing sustained release of the drug in the body. Background & Unmet Need: There are a number of biological barriers to cellular drug delivery. Simple diffusion across the cell membrane is feasible...

Published: 4/9/2019 | Inventor(s): Jayanth Panyam, Mahesh Chavanpatil

Keywords(s): Drug Delivery, Nanomaterials

Category(s): Drug Delivery, Life Science, Nanomaterials, Therapeutics

Improved pDMI Inhaler Formulations

Novel biodegradable, non-toxic nanoparticles that act as stabilizing excipients with a wide variety of suspension drug candidates including polar & non-polar drug particles, bio-macromolecules (proteins/peptides), gene therapies (DNA/siRNA) as well as amorphous and crystalline therapeutics have been developed which provide a platform for improving...

Published: 11/11/2021 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Asthma, Drug Delivery, Formulation, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Life Science, Therapeutics, Nano-based