CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines

Case ID:
14-1256

CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines  

WSU Tech#: 15-1256

Technology Summary:

CJ4.1A and CJ4.3C are rat conjunctival epithelial cell lines. The cell lines were developed to investigate antigen translocation across a mucosal barrier. Conjuctival epithelial cells from Fischer 344 rats were immortalized with pSV3(neo) resulting in cell lines CJ4.1A and CJ4.3C. Cells express SV40 T-Antigen, conjunctiva specific cytokeratin 4, goblet cell specific cytokeratin 7 and negative for epithelial cell-specific cytokeratin 12.  The cells were passaged over 60 times with established doubling times.

 

Competitive Advantages

 

No competitors found for this line.

 

Benefit Analysis:

 

These are the only rat conjunctival cell lines known to inventors. They are useful in studying/modeling the conjunctival epithelial barrier. Studying the ability of soluble and particulate antigens ability to cross the conjunctival barrier.

 Stage of Development: Available

No further development planned.

 

Patent Status:

 

Controlled by NDA.

 

Licensing Opportunity:

WSU is looking for a commercial partners interested in furthering the validation of this technology and bringing the technology to market.  The inventors would be open to assist in the generation of SBIR/STTR  grants to fund the further development of this technology.

 

Contact for Further Information:  

Frank Urban, MS, CBA, BA.   email: frank.urban@wayne.edu   Phone (mobile): (734) 355-0730

Patent Information:
For Information, Contact:
John Shallman
Wayne State University
dd2514@wayne.edu
Inventors:
Nancy O'Sullivan
Alfred Baylor III
Paul Montgomery
Keywords: