CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines

Case ID:

CJ4.1A and CJ4.3C Rat Conjunctival Epithelial Cell Lines  

WSU Tech#: 15-1256

Technology Summary:

CJ4.1A and CJ4.3C are rat conjunctival epithelial cell lines. The cell lines were developed to investigate antigen translocation across a mucosal barrier. Conjuctival epithelial cells from Fischer 344 rats were immortalized with pSV3(neo) resulting in cell lines CJ4.1A and CJ4.3C. Cells express SV40 T-Antigen, conjunctiva specific cytokeratin 4, goblet cell specific cytokeratin 7 and negative for epithelial cell-specific cytokeratin 12.  The cells were passaged over 60 times with established doubling times.


Competitive Advantages


No competitors found for this line.


Benefit Analysis:


These are the only rat conjunctival cell lines known to inventors. They are useful in studying/modeling the conjunctival epithelial barrier. Studying the ability of soluble and particulate antigens ability to cross the conjunctival barrier.

 Stage of Development: Available

No further development planned.


Patent Status:


Controlled by NDA.


Licensing Opportunity:

WSU is looking for a commercial partners interested in furthering the validation of this technology and bringing the technology to market.  The inventors would be open to assist in the generation of SBIR/STTR  grants to fund the further development of this technology.



Patent Information:
For Information, Contact:
Robert Olson
Wayne State University
Nancy O'sullivan
Alfred Baylor Iii
Paul Montgomery