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Multi-parametric Acoustic, Optical and Mechanical Imaging of Cervical Tissue Insufficiencies to Predict Preterm Birth
An enhanced image-guidance system that integrates ultrasound and photoacoustic into existing ablation systems to provide an enhanced image-guidance system for identification of cervical tissue changes during pregnancy and postpartum.
Technology Summary
Preterm delivery is a main cause of perinatal morbidity and mortality worldwide, which is associated...
Published: 10/1/2025
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Inventor(s): Mohammad Mehrmohammadi, Sonia Hassan, Edgar Hernandez-Andrade, Yan Yan, Maryam Basij
Keywords(s): Driving Lifelong Health
Category(s): Technology Category > Women's Health, Technology Category > Medical Devices, Technology Category > Life Science, Technology Category > Imaging, Technology Category > Acoustics
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Using Nanotechnology to Target Aggressive Cancers
A modified gold nanoparticle is used to target aggressive triple negative breast cancer and melanoma by inhibiting RAD6 which is overexpressed in aggressive and chemo resistant cancers.
Technology Summary
This technology utilizes gold nanoparticles (GNPs) conjugated with a small molecule inhibitor (SMI#9) designed to target RAD6, a protein overexpressed...
Published: 9/26/2025
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Inventor(s): Malathy Shekhar, Guangzhao Mao, Yanhua Zhang
Keywords(s): Breast Cancer, Driving Lifelong Health, Nanotechnology
Category(s): Technology Category > Therapeutics, Technology Category > Oncology, Technology Category > Nanomaterials, Technology Category > Life Science, Technology Category > Drug Delivery, Technology Category > Cancer, Technology Category > Women's Health
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Polyclonal and Monoclonal Antibodies to TPH1 and TPH2
This technology is a set of antibodies that is used with immunohistochemistry techniques to differentiate between tryptophan hydroxylase 1 and 2, enabling scientists to study how the two enzymes are differentially regulated.
Technology Summary
The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode enzymes in serotonin biosynthesis. Variants...
Published: 9/26/2025
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Inventor(s): Donald Kuhn
Keywords(s): Antibody, Assay, Driving Lifelong Health, Immunoassay
Category(s): Technology Category > Research tools, Technology Category > Life Science, Technology Category > Biological materials, Technology Category > Research tools > Antibodies
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Transgenic Mice Carrying Wild Type Human Her-2 Under the Whey Acidic Promoter
This transgenic line expresses the human ERBB2 (HER2) gene in mammary gland and brain, displays tolerance to ERBB2 antigen and may be useful in testing ERBB2-based vaccines and immunotherapies.
Technology Summary
Her-2 positive breast cancer is a breast cancer that is positive for a protein called human epidermal growth factor receptor 2 (Her-2)....
Published: 9/26/2025
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Inventor(s): Wei-Zen Wei, Ye-Shih Ho, Marie Piechocki
Keywords(s): Animal Model, Breast Cancer, Driving Lifelong Health, Research Tool
Category(s): Technology Category > Research tools, Technology Category > Life Science, Technology Category > Animal models
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A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue
This invention is a new and simple method for the identification of active versus latent matrix metalloprotease enzymes (MMPs) in tissue.
Technology Summary
MMPs are involved in tumor progression and therefore are targets for anti-cancer drug therapies. However, most drug therapies directed at inhibition of MMPs have failed because there is no reliable...
Published: 9/26/2025
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Inventor(s): Avraham Raz, Rafael Fridman, Pratima Nangia-Makker
Keywords(s): Biomarker, Cancer, Driving Lifelong Health, Enzyme, Method
Category(s): Technology Category > Therapeutics, Technology Category > Research tools, Technology Category > Oncology, Technology Category > Life Science, Technology Category > Diseases, Technology Category > Research tools > Antibodies
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