Description:
A novel 9‑compartment physiologically based pharmacokinetic model that predicts drug distribution and exposure in the human brain and brain tumors to improve treatment outcomes. SpatialCNS-PBPK is an advanced, web-based platform implementing a 9-compartment PBPK model that simulates spatial pharmacokinetics of drugs within the central nervous system, accounting for complex barriers like the blood-brain barrier and blood-brain tumor barrier. It enables accurate predictions of drug concentrations in brain blood, parenchyma, cerebrospinal fluid, and tumor regions, validated against established pharmacokinetic simulators, and supports drug development and clinical optimization.
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Key Advantages:
- Comprehensive 9-compartment model capturing anatomical and physiological brain complexity
- User-friendly web-based R/Shiny interface for easy simulation and analysis
- Validated accuracy through correlation with established software (Simcyp Simulator)
- Facilitates sensitivity analyses to optimize drug delivery strategies
- Detailed user guide enhancing accessibility for researchers and clinicians
- Improves the prediction of drug penetration across the blood-brain and blood-brain tumor barriers
- Novel tool for spatial pharmacokinetic modeling in the central nervous system
- Minimizes difficulties in optimizing brain-targeted therapies due to heterogeneous drug distribution
- Reduces complexity in designing effective clinical trials for brain disorders and tumors
Market Opportunities:
- Drug development pipelines targeting central nervous system disorders and brain cancers
- Clinical trial design and optimization for brain-penetrant therapeutics
- Pharmacokinetic research in neuroscience and oncology
- Personalized medicine approaches to improve drug efficacy in brain diseases
- Academic and pharmaceutical research tools for CNS drug delivery studies
Stage of Development:
Pre-Clinical
Patent Status:
Pending
References & Publications:
2024, Jing Li, Charuka Wickramasinghe, Andrew Wu, Yuanyuan Jiang, Jun Jiang, Artak Tovmasyan, Seongho Kim, Nader Sanai PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING OF SPATIAL HETEROGENEITY OF DRUG PENETRATION AND EXPOSURE IN THE HUMAN BRAIN AND BRAIN TUMORS NEURO-ONCOLOGY, 2024
