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Liposomal Vancomycin-Cefazolin Nanoparticle for Treating Infections
A novel liposomal nanoparticle delivering vancomycin and cefazolin enhanced with targeting ligands improves treatment efficacy of Staphylococcus aureus infections, including MRSA, while reducing kidney toxicity.
Technology Summary
“Methicillin-resistant Staphylococcus aureus (MRSA) represents one of the most significant...
Published: 4/21/2026
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Inventor(s): Arun Iyer, Michael Rybak, Samaresh Sau, Ketki Bhise, Razie Kebriael
Keywords(s):
Category(s): Technology Category > Life Science, Technology Category > Drug Delivery, Technology Category > Infectious disease, Technology Category > Driving Lifelong Health
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Insulin Crystals Removal Platform
Description:
A platform technology for improving insulin delivery by removing insulin-derived fibrils through polyester membrane filtration.
This invention employs membrane filters integrated into insulin delivery systems to selectively remove insulin-derived fibrils (IDFs) from insulin formulations. By filtering out fibrils while preserving active...
Published: 1/27/2026
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Inventor(s): Ulrike Klueh
Keywords(s):
Category(s): Technology Category > Biomedical, Technology Category > Devices, Technology Category > Drug Delivery, Technology Category > Life Science, Technology Category > Medical Devices
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“Smart” Glucose-Responsive Insulin
Technology Summary
A "smart" or glucose-responsive insulin that can automatically respond to changes in a patient’s blood stream and help treat patients with type 1 diabetes. This technology comprises compositions that integrate a zwitterionic polymer, insulin moieties, saccharide moieties, and saccharide binding molecules to create...
Published: 1/9/2026
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Inventor(s): Zhiqiang Cao
Keywords(s):
Category(s): Technology Category > Biological materials, Technology Category > Chemical Processing/Synthesis, Technology Category > Drug Delivery, Technology Category > Process/Procedure, Technology Category > Small molecule, Technology Category > Therapeutics, Technology Category > Life Science
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Portable Thermal Nitric Oxide Generation Technology
Novel chemical composition that enables pure NO gas release upon heat.
Technology Summary
This technology enables safe, efficient, and portable generation of medical-grade nitric oxide (NO) by thermally activating a bench-stable solid-state NO-releasing molecule embedded in a porous polymer matrix. FDA approved Inhaled nitric...
Published: 12/16/2025
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Inventor(s): James Bour, Shuxiao Li
Keywords(s):
Category(s): Technology Category, Technology Category > Medical Devices, Technology Category > Drug Delivery, Technology Category > Driving Lifelong Health, Technology Category > Life Science
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Methods For The Prediction Of Drug Penetration and Exposure In The Human Brain
Description:
A novel 9‑compartment physiologically based pharmacokinetic model was developed and fully validated for prediction of heterogeneous drug distribution and exposure in the human central nervous system (CNS) and brain tumors. The 9-compartment model accounts for the general anatomical structure and pathophysiology of the human CNS and brain...
Published: 11/21/2025
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Inventor(s): Jing Li, Seongho Kim, Charuka Wickramasinghe
Keywords(s):
Category(s): Technology Category > Life Science, Technology Category > Method, Technology Category > Drug Screening, Technology Category > Drug Delivery
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Ruthenium-based caging of nitrile-containing enzyme inhibitors
Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the pathophysiology...
Published: 9/15/2025
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Inventor(s): Jeremy Kodanko, Claudia Turro
Keywords(s): Cancer, Pharmaceuticals
Category(s): Technology Category > Physical Sciences, Technology Category > Other, Technology Category > Life Science, Technology Category > Drug Delivery, Technology Category > Chemicals
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