Search Results - biotechnology

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Tx2 metal-binding tag for purification and identification of recombinant proteins

Tx2 Metal-Binding Tag for Purification and Identification of Recombinant Proteins WSU Tech#: 11-1058Technology Summary: The technology is a new method of protein purification similar to the principles behind that of a histidine and Ni column system. The new technology uses a different amino acid sequence for generating a metal-binding cluster:T: “H...

Published: 2/28/2022 | Inventor(s): Jian-Ping Jin

Keywords(s): Assay, Biotechnology, Process, Protein, Reagents, Tool

Category(s): Life Science, Research tools, Protein/peptides

Ambulatory systemic blood pressure telemonitoring

A non-invasive sensor method to determine ambulatory systemic blood pressure in the adult or pediatric population through the use of telemonitoring.Background & Unmet Need:Currently, non-invasive systems to measure blood pressure suffer from inaccuracies. They can vary significantly and there is no easy-to-use accurate way to determine ambulatory...

Published: 4/26/2022 | Inventor(s): Sean Wu, Gaurav Kapur, Yong Xu, Lingguang Chen, William Lyman

Keywords(s): Biotechnology, Device, Patient Monitoring

Category(s): Medical Devices, Life Science

ERK-Mediated Grb7 Phosphorylation: A Biomarker and Potential Therapeutic Target in Her2/Grb7 Amplified Cancers

This invention is a new bio-marker for breast and other cancers that have Her2 and Grb7 gene amplifications, thus providing a therapeutic intervention in Her2/Grb7 amplified cancers.Background40% of breast cancers, as well as several other cancer types, display increased activation of tyrosine kinases from the ErbB family, with Her2 found amplified...

Published: 3/12/2018 | Inventor(s): Guri Tzivion, Deborah Leicht, Alexander Kaplun, Stephen Ethier

Keywords(s): Biomarker, Biotechnology, Cancer, Cancer Therapies, Therapeutics

Category(s): Diagnostic, Life Science, Oncology

Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging

Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI...

Published: 5/1/2018 | Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf

Keywords(s): Biotechnology, Imaging

Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools

GlyB4 Fusion with Neuregulin Heparin-Targeting Domain to Block Neuregulin Signaling

We have harnessed this natural targeting ability of NRG by fusing the HBD of NRG to soluble HER4. This fusion protein retains high affinity heparin binding to heparin and to cells that express heparan sulfates resulting in a more potent NRG antagonist. In vivo, it is targeted to peripheral nerve segments where it blocks the activity of NRG as a Schwann...

Published: 12/6/2022 | Inventor(s): Jeffrey Loeb, Qunfang Lee

Keywords(s): Anti-cancer, Biotechnology, Cancer risk, Cancer Therapies, Drug Delivery, Drug Target, Epilepsy

Category(s): Life Science, Drug Delivery, Other

Microfluidic Particle Concentration and Separator

Researchers at the Wayne State University Smart Sensors and Integrated Microsystems (SSIM) laboratory have developed a micro-scale concentrator and separator applicable to several microfluidic applications. Initially the device was developed to concentrate and separate bacteria from other impurities to test water quality however the micro separator...

Published: 9/10/2021 | Inventor(s): Gregory Auner, Chung-Chu Chen

Keywords(s): Biotechnology

Category(s): Physical Sciences, Microfluidics, MEMS

Folate Receptor Targeted Therapeutics for Cancer

WSU researchers, in collaboration with Duquesne University, have developed a series of novel folate analogs that show selective toxicity toward tumor cells expressing high levels of the surface protein folate receptor. This invention has potential in the development of targeted antitumor drugs. Background & Unmet Need: Folate metabolism plays...

Published: 11/19/2021 | Inventor(s): Larry Matherly, Aleem Gangjee

Keywords(s): Biotechnology, Cancer, Cancer Therapies

Category(s): Therapeutics, Life Science, Oncology, Diseases