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Using Nanotechnology to Target Aggressive Cancers

A modified gold nanoparticle is used to target aggressive triple negative breast cancer and melanoma by inhibiting RAD6 which is overexpressed in aggressive and chemoresistant cancers. Technology Summary This technology utilizes gold nanoparticles (GNPs) conjugated with a small molecule inhibitor (SMI#9) designed to target RAD6, a protein overexpressed...

Published: 8/22/2025 | Inventor(s): Malathy Shekhar, Guangzhao Mao, Yanhua Zhang

Keywords(s): Breast Cancer, Nanotechnology

Category(s): Life Science, Oncology, Drug Delivery, Therapeutics, Cancer, Nanomaterials

Imaging Tandem Mass Spectrometry: Reduction to Practice

Currently, tandem mass spectrometry is typically performed by selecting a single mass peak in a time of flight or quadrupole mass spectrometer, which is then fragmented through collision, after which the products are mass-selected in a quadrupole or similar secondary mass spectrometer. A Wayne State University researcher has developed an alternative...

Published: 8/28/2025 | Inventor(s): Arthur Suits, Myung Kim, Brian Leskiw

Keywords(s): Diagnostics, Instrumentation, Method

Category(s): Instrumentation, Physical Sciences, Spectroscopy, Imaging, Other

Wearable Ear Sensor for continuous health monitoring.

WSU researchers have developed an ultrasmall, low power technology to sense heart rate, pulse wave velocity (PWV), blood oxygenation and blood pressure. The device uses a digital optical proximity sensor (OPS) which integrates LED light sources, detectors and signal processors into a 4mm square and consumes <200 microwatts, which represents a 10X...

Published: 7/15/2025 | Inventor(s): Amar Basu

Keywords(s):

Category(s): Bioengineering, Electronics, Medical Devices, Sensors, Life Science

CMOS Laddered Inverter Ring Oscillator

Low-Power, Multi-Phase, CMOS-based Ring Oscillator Circuit Background: CMOS technology is used for constructing integrated circuit (IC) chips, including microprocessors, microcontrollers, memory chips (including CMOS BIOS), and other analog and digital logic circuits. A CMOS ring oscillator circuit is an odd number (N) of inverting stages connected...

Published: 12/6/2022 | Inventor(s): Melvin Edwards II, Mohammad Alhawari

Keywords(s): IoT

Category(s): Communications, Physical Sciences, Electronics, Electrical

Discovery of Well Defined Sulfated Glycopolymers as Specific Heparanase Inhibitors for Cancer Therapeutics

The remodeling of the extracellular matrix has been shown to be highly upregulated in cancer and inflammation and is critically linked to the processes of invasion and metastasis. The finding that heparanase is elevated in a wide variety of tumor types and is subsequently linked to the development of pathological processes has led to an explosion of...

Published: 12/2/2020 | Inventor(s): Hein Nguyen, Ravi Loka, Eric Sletten, Israel Vlodavsky

Keywords(s): Cancer, Cancer Therapies, Pharmaceuticals, Therapeutics

Category(s): Life Science, Oncology, Pharmaceuticals, Therapeutics

A method to induce ferroptosis and to downregulate androgen receptor/androgen receptor splice variant in prostate cancer cells

Prostate cancer (PCa) effects approximately three million men in the United States every year. About 10-20% of the cases of prostate cancer are castrate-resistant prostate cancer (CRPC). This form of PCa is highly resistant to what Is known as androgen depletion therapy and is often fatal. All types of PCa are sensitive to androgen receptor signaling...

Published: 12/18/2024 | Inventor(s): Zhihui Qin, Liping Xu

Keywords(s): Anti-cancer, Cancer, Cancer Therapies, Drug Delivery, Drug Target, Prostate Cancer

Category(s): Medical, Diseases, Drug Discovery, Pharmaceuticals, Oncology

Identification of Galeterone's mechanism of action leading to novel treatment therapies for castrate resistant prostate cancer (CRPC)

Castration-Resistant Prostate Cancer (CRPC) or Hormone Refractory Prostate Cancer (HRPC), is a type of prostate cancer that typically recurs after administering androgen deprivation therapy (ADT). The need for effective therapies for these difficult to treat cancers is gaining prominence in the prostate cancer market. The global CRPC market is poised...

Published: 4/16/2025 | Inventor(s): Qingping Dou, Huanjie Yang, Elisabeth Heath

Keywords(s):

Category(s): Life Science, Oncology, Pharmaceuticals, Receptors/targets, Process/Procedure, Small molecule, Therapeutics

Ultra-Specific and Ultra-Sensitive Platform for Highly-Reliable and High-Precision SARS-CoV-2 Detection

Background:The technology described is based on the use of two unique sets of detection molecules that are specific to a protein contained in the viral shell of SARS CoV-2 and Covid-19 that is unique from other known common cold causing coronaviruses. The proposed system uses two different fluorescent probes for two different regions of the viral shell...

Published: 8/7/2025 | Inventor(s): Rodrigo Fernandez-Valdivia

Keywords(s): Coronavirus, COVID-19, Diagnostic, Virus

Category(s): Diagnostic, Biomedical, Medical, Diseases, Infectious disease

Disulfide by Design 2.0: A web-based tool for disulfide engineering in proteins

Background:Immunoinformatics employs a computer-driven approach to identifying fragments of the target pathogen that would provide a suitable vaccine, avoiding potential safety concerns from the more traditional approach of using whole pathogens. Immunoinformatics now plays a crucial role in vaccine design, immunodiagnostic development, and antibody...

Published: 4/18/2022 | Inventor(s): Alan Dombkowski, Douglas Craig

Keywords(s): Coronavirus, COVID-19

Category(s): Life Science, Software, Simulation & Modeling, Research tools, Computer Software, Protein/peptides

Microfluidic platforms for live-cell imaging and bio/pathomimetic tissue models

Background:Methodologies to image and quantify tissue models using high-content analysis (HCI) and functional analyses of 3D avatars are needed as such avatars better recapitulate the phenotype of pathobiological processes and better predict efficacy of, and resistance to, a wide variety of therapies. Furthermore, changes in morphometry, viability,...

Published: 2/14/2022 | Inventor(s): Bonnie Sloane, Kamiar Moin, Kyungmin Ji, Kingsley Osuala, Yong Xu, Hongen Tu

Keywords(s):

Category(s): Specialty compounds, Research tools, Oncology, Microfluidics, Life Science, Instrumentation, Imaging, Diseases, Devices, Cell lines

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