Search Results - assays

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Fc-folate conjugate for the treatment of triple negative breast cancer

Approximately 13% of women in the United States will develop breast cancer according to the American Cancer Society. That makes breast cancer the second leading cause of cancer death in women right behind lung cancer. Triple negative breast cancer (TNBC) represents about 10 – 20% of all breast cancers. Triple negative refers to cancer cells...

Published: 10/31/2024 | Inventor(s): Cecilia Speyer

Keywords(s): Anti-cancer, Breast Cancer, Cancer, Cancer Therapies

Category(s): Antibodies, Assays, Biology, Biomedical, Chemical Processing/Synthesis, Diseases, Drug Delivery, Life Science, Oncology, Protein/peptides, Receptors/targets, Small molecule, Therapeutics

Sarcoidosis and TB Biomarkers

Sarcoidosis and TB Biomarkers WSU Tech#: 15-1276 Technology Summary: This technology includes a new method for generating phage libraries and clones that are useful in discovering biomarkers from human blood samples. The inventors looked at the change in immune cells versus that of the infected tissue (BAL and blood) used this to generate biomarkers...

Published: 3/2/2020 | Inventor(s): Lobelia Samavati, Harvinder Talwar, Felix Madrid, Rita Rosati, Jia Li

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Category(s): Assays, Biotechnology, Diagnostic

"Generation of an affinity-purified rabbit anti-CREBH polyclonal antibody"

Generation of an Affinity-Purified Rabbit Anti-CREBH Polyclonal Antibody WSU Tech#: 15-1271Technology Summary: CREBH (also called CREB3L3) is a stress-inducible metabolic regulator that plays key roles in hepatic lipolysis, fatty acid oxidation, gluconeogenesis, and lipogenesis. CREBH is critically involved in fatty liver disease and its associated...

Published: 2/28/2022 | Inventor(s): Kezhong Zhang

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Category(s): Research tools, Antibodies, Assays

Vaginal microbiome snapshot (VMS)

Vaginal Microbiome Sanpshot; a Method for Diagnosing Bacterial Vaginosis and Other Vaginal Disorders WSU Tech#: 13-1141 Technology Summary: Bacterial vaginosis (BV) is a disease of the vagina caused by an imbalance of naturally occurring bacterial flora and is often confused with yeast infection (candidiasis) or infection with Trichomonas vaginalis...

Published: 10/27/2020 | Inventor(s): Robert Akins, Jack Sobel

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Category(s): Assays, Biomedical, Diagnostic, Diagnostics, Infectious disease

Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors

Background: Often referred to as the crucial "drug discovery tool", cell based technology is one of the most significant sectors of pharmaceutical research and development. Of particular importance has been the development of information-rich cellular assays that determine drug candidate efficacy and safety (target identification, validation...

Published: 4/17/2022 | Inventor(s): Leon Carlock, Maria Cypher

Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics

Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines, Oncology

Peptide Antimicrobial

In vivo Display Technology for the Isolation of Antimicrobial Peptides Professor Philip R. Cunningham, Ph.D. Department of Biological Sciences @ Wayne State University Interest in peptides as antimicrobial agents has increased dramatically in recent years, driven primarily by the development of new technologies for producing, screening and analyzing...

Published: 12/7/2022 | Inventor(s): Philip Cunningham, Wes Colangelo

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Category(s): Pharmaceuticals, Life Science, Research tools, Assays, Biological materials, Protein/peptides

Fluorescence-Based Assay for Demethylation

Detailed Description WSU researchers have developed a fluorescence-based assay for the dealkylation activity of the non-heme iron (II) a-ketoglutarate-dependent dioxygenase family of enzymes. This assay uses formaldehyde dehydrogenase to convert formaldehyde to formic acid and monitors the creation of an NADH analog using fluorescence. The technology...

Published: 11/26/2019 | Inventor(s): Ashok Bhagwat, Todd Roy

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Category(s): Assays, Life Science, Research tools

Biologically active ATP-Analogs for tagging phosphoproteins

A novel Photo Cross Linking Assay (PCLA) for targeting protein phosphorylation Protein phosphorylation catalyzed by kinases and phosphatases act at critical control points that regulates many cellular processes. This central role makes them an attractive target for identifying largely untapped and important biomarkers for disease diagnostics. Understanding...

Published: 11/11/2021 | Inventor(s): Mary Pflum

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Category(s): Chemicals, Life Science, Research tools, Assays, Reagents