Search Results - biotechnology

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Generation of gp78 null mice WSU Tech#: 15-1291 Technology: Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis,...

Published: 11/22/2021 | Inventor(s): Avraham Raz, Andrei Golovko

Keywords(s):

Category(s): Animal models, Biology, Biomedical, Biotechnology, Drug Delivery, Drug Discovery, Drug Screening, Genomics/Genetics, Life Science, Oncology, Research tools

Sarcoidosis and TB Biomarkers

Sarcoidosis and TB Biomarkers WSU Tech#: 15-1276 Technology Summary: This technology includes a new method for generating phage libraries and clones that are useful in discovering biomarkers from human blood samples. The inventors looked at the change in immune cells versus that of the infected tissue (BAL and blood) used this to generate biomarkers...

Published: 3/2/2020 | Inventor(s): Lobelia Samavati, Harvinder Talwar, Felix Madrid, Rita Rosati, Jia Li

Keywords(s):

Category(s): Assays, Biotechnology, Diagnostic

Population Control of Invasive Plant Species by Gene Silencing and Restoration of Native Plant Communities

Population Control of Invasive Plant Species by Gene Silencing and Restoration of Native Plant Communities WSU Tech#: 13-1173 Technology Summary: The invention utilizes a gene silencing processes to control the spread of invasion plant species and to restore native plant communities. Developed a gene-silencing vector that has been successfully...

Published: 3/3/2020 | Inventor(s): Edward Golenberg, Carl Freeman

Keywords(s):

Category(s): Agriculture, Biologics, Biotechnology, Environment, Gene Therapy

GENERATION OF 5-FLUOROURACIL + OXALIPLATIN RESISTANT COLON CANCER CELLS: A TOOL TO STUDY CANCER RECURRENCE AND DRUG RESISTANCE

Generation of 5-Fluorouracil + Oxaliplatin Resistant Colon Cancer Cells WSU Tech#: 13-1154 Technology Summary: A significant obstacle for the successful management of patients with colorectal cancer (CRC) is intrinsic drug resistance or, in patients who respond to chemotherapy, acquired drug resistance. Drug resistance can occur through a variety...

Published: 11/19/2021 | Inventor(s): Adhip Majumdar, Yingjie Yu

Keywords(s):

Category(s): Biomedical, Biotechnology, Cell lines, Characterization, Drug Discovery, Oncology, Research tools

Development of a multimolecular and multimodular biomarker panel for the early screening, molecular distinction and clinical follow-up of patients developing preeclampsia/HELLP syndrome and its preparation for preclinical testing

Development of a Multimolecular and Multimodular Biomarker Panel for the Early Screening, Molecular Distinction and Clinical Follow-Up of Patients Developing Preeclampsia/HELLP Syndrome and its Preparation for Preclinical Testing WSU Tech#: 12-1110 Technology Summary: Preeclampsia is a pregnancy complication characterized by high blood pressure and...

Published: 3/3/2020 | Inventor(s): Nandor Than, Adi Tarca, Gabor Juhasz, Adrienna Kekesi, Hamutal Meiri, Zoltan Papp, Roberto Romero

Keywords(s):

Category(s): Medical, Biotechnology, Diagnostic, Diagnostics, Genomics/Genetics, Prenatal, Proteomics

Long non-protein-coding RNA molecules as therapeutics for epilepsy.

Long Non-Coding RNA Molecules as Therapeutics for Epilepsy WSU Tech#: 12-1089 Technology Summary: Long Non-coding RNA (lncRNA) were first described in 2002 from mouse, making this a relatively new technology. lncRNA transcripts far exceed the number of protein coding mRNAs in the mammalian transcriptome, but in lower copy numbers. Inventors...

Published: 10/5/2023 | Inventor(s): Jeffrey Loeb, Leonard Lipovich

Keywords(s):

Category(s): Medical, Bioinformatics, Biomedical, Biotechnology, Diagnostic, Diagnostics, Drug Discovery, Pharmaceuticals, Therapeutics

Sentinel Cell

Sentry Cell (Macrophage Hazardous Material Detection) WSU Tech#: 10-991 Technology Summary: This technology is designed around an isolated cell system for the detection of an energetic material comprising of an isolated stationary macrophage cell isolated from a vestibular labyrinth of a Opsanus sp. This macrophage cell is plated in...

Published: 1/9/2023 | Inventor(s): Robert Silver

Keywords(s): Imaging, Process, Research Tool

Category(s): Process/Procedure, Biotechnology, Environment, Safety

Toxicological high throughput screens based on prioritized differentiation of mouse viable potency reporter, and viable first differentiated lineage reporter, mouse embryonic stem cells

Toxicological High-Throughput Screens Based on Prioritized Differentiation of Mouse Viable Potency Reporter, and Viable First Differentiated Lineage Reporter, Mouse Embryonic Stem Cells WSU Tech#: 15-1279 Technology Summary: This technology provides systems and methods to detect stress in stem cells where the detected stressor might affect all stem...

Published: 3/3/2020 | Inventor(s): Daniel Rappolee, Elizabeth Puscheck

Keywords(s):

Category(s): Drug Screening, Biotechnology

Regulators of Peritoneal Healing and Adhesion Development

WSU researchers have identified a novel approach to reduce postoperative adhesion development. This invention identifies new targets for regulation of healing and fibrosis, so as to decrease or increase the process depending on the clinical need. NF-kappa has shown to be differently expressed in fibroblasts from normal peritoneum and adhesions....

Published: 4/30/2014 | Inventor(s): Michael Diamond, Ghassan Saed

Keywords(s):

Category(s): Biotechnology

High Efficient Reagent that Transfers Protein into the Living Mammalian Cells

This invention is a new protein transduction method for efficient delivery of exogenous proteins into mammalian cells. In contrast to known protein transduction methods, this new approach has the capability of targeting transduced proteins to different cellular compartments, as well as protecting the proteins from degradation by cellular proteases....

Published: 11/9/2021 | Inventor(s): Qianqian Li, Jianjun Wang

Keywords(s): Protein

Category(s): Biotechnology, Life Science, Reagents, Research tools

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