Search Results - pharmaceuticals




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Discovery of Well Defined Sulfated Glycopolymers as Specific Heparanase Inhibitors for Cancer Therapeutics
The remodeling of the extracellular matrix has been shown to be highly upregulated in cancer and inflammation and is critically linked to the processes of invasion and metastasis. The finding that heparanase is elevated in a wide variety of tumor types and is subsequently linked to the development of pathological processes has led to an explosion of...
Published: 12/2/2020   |   Inventor(s): Hein Nguyen, Ravi Loka, Eric Sletten, Israel Vlodavsky
Keywords(s): Cancer, Cancer Therapies, Pharmaceuticals, Therapeutics
Category(s): Life Science, Oncology, Pharmaceuticals, Therapeutics
A method to induce ferroptosis and to downregulate androgen receptor/androgen receptor splice variant in prostate cancer cells
Prostate cancer (PCa) effects approximately three million men in the United States every year. About 10-20% of the cases of prostate cancer are castrate-resistant prostate cancer (CRPC). This form of PCa is highly resistant to what Is known as androgen depletion therapy and is often fatal. All types of PCa are sensitive to androgen receptor signaling...
Published: 11/19/2020   |   Inventor(s): Zhihui Qin, Liping Xu
Keywords(s): Anti-cancer, Cancer, Cancer Therapies, Drug Delivery, Drug Target, Prostate Cancer
Category(s): Medical, Diseases, Drug Discovery, Pharmaceuticals, Oncology
Identification of Galeterone's mechanism of action leading to novel treatment therapies for castrate resistant prostate cancer (CRPC)
Castration-Resistant Prostate Cancer (CRPC) or Hormone Refractory Prostate Cancer (HRPC), is a type of prostate cancer that typically recurs after administering androgen deprivation therapy (ADT). The need for effective therapies for these difficult to treat cancers is gaining prominence in the prostate cancer market. The global CRPC market is poised...
Published: 11/19/2020   |   Inventor(s): Qingping Dou, Huanjie Yang, Elisabeth Heath
Keywords(s):  
Category(s): Life Science, Oncology, Pharmaceuticals, Receptors/targets, Process/Procedure, Small molecule, Therapeutics
SALT-FORMULATED VALPROATE AS A TOPICAL ANTI-FUNGAL TREATMENT
In 2018, the global antifungal drugs market size was valued at USD 11.6 billion. Generally speaking, 54.3% of sales are prescription and 45.7% is over-the counter OTC/Alternative. It is anticipated that the OTC/Alternative portion of the global antifungal market will continue to grow. Science is indicating that both the number of systemic infections...
Published: 4/6/2020   |   Inventor(s): Miriam Greenberg, Rania Deranieh
Keywords(s):  
Category(s): Diseases, Infectious disease, Life Science, Small molecule, Pharmaceuticals
Drugs that disrupt interactions between ELK1 and the androgen receptor to suppress growth of both early stage and castration resistant prostate cancer
Background:Prostate cancer is the second-most commonly diagnosed cancer among men and the fifth most common cause of male cancer death worldwide. Although tumors are often initially sensitive to medical or surgical therapies that decrease levels of testosterone, continued disease progression generally represents a transition to the lethal variant. In...
Published: 10/22/2019   |   Inventor(s): Manohar Ratnam, Rayna Rosati, Mugdha Patki
Keywords(s):  
Category(s): Life Science, Therapeutics, Oncology, Drug Discovery, Pharmaceuticals
Long non-protein-coding RNA molecules as therapeutics for epilepsy.
Long Non-Coding RNA Molecules as Therapeutics for Epilepsy WSU Tech#: 12-1089 Technology Summary: Long Non-coding RNA (lncRNA) were first described in 2002 from mouse, making this a relatively new technology. lncRNA transcripts far exceed the number of protein coding mRNAs in the mammalian transcriptome, but in lower copy numbers. Inventors have...
Published: 5/19/2017   |   Inventor(s): Jeffrey Loeb, Leonard Lipovich
Keywords(s):  
Category(s): Medical, Bioinformatics, Biomedical, Biotechnology, Diagnostic, Diagnostics, Drug Discovery, Pharmaceuticals, Therapeutics
CARP-1/CCAR1 Functional Mimetics (CFMs): Novel small molecule suppressors of human breast cancer cell growth.
BackgroundCARP-1 (Cell cycle and apoptosis regulator protein) is a regulator of cell growth signaling. CARP-1 plays an important role in apoptosis (cell death) induction in human breast cancer (HBC) cells in the presence of the chemotherapy agent Adriamycin. The researchers have found that CARP-1 inhibits cell growth by binding with the anaphase...
Published: 5/19/2017   |   Inventor(s): Arun Rishi
Keywords(s):  
Category(s): Medical, Drug Discovery, Life Science, Oncology, Pharmaceuticals
Topical IL-1Ra (anakinra) in the form of gel to treat persistent diabetic skin and corneal wounds
BackgroundAnakinra (aka. Kineret) is a recombinant human IL-1Ra that was developed by Amgen. It is currently used to treat moderately to severely active rheumatoid arthritis, but also treats neonatal-onset multisystem inflammatory disease (NOMID). Anakinra is given as an IV dose and the drug is no longer under patent. The properties of Anakinra are...
Published: 5/25/2016   |   Inventor(s): Fu-Shin Yu
Keywords(s):  
Category(s): Biologicals, Drug Discovery, Pharmaceuticals, Therapeutics
Co-polymer Stabilizers for Pressured Metered Dose Inhalers (pMDIs)
A series of novel co polymer surfactants with the general structure LAmEOnLAm were developed along with a Colloidal Probe Microscopy (CPM) method to optimize the surfactant composition using adhesion forces to improve stabilization of drug dispersions. This expands the range of biomolecules and micronized drug particles that can be formulated with pMDIs....
Published: 8/14/2013   |   Inventor(s): Sandro Da Rocha, Libo Wu
Keywords(s): Assay, Asthma, Compound, Device, Drug Delivery, Formulation, Instrumentation, Method, Pharmaceuticals, Process, Therapeutics
Category(s): Chemicals, Drug Delivery, Pharmaceuticals, Instrumentation, Materials
Peptide Antimicrobial
In vivo Display Technology for the Isolation of Antimicrobial Peptides Professor Philip R. Cunningham, Ph.D. Department of Biological Sciences @ Wayne State University Interest in peptides as antimicrobial agents has increased dramatically in recent years, driven primarily by the development of new technologies for producing, screening and analyzing...
Published: 5/3/2011   |   Inventor(s): Philip Cunningham, Wes Colangelo
Keywords(s):  
Category(s): Pharmaceuticals, Life Science, Research tools, Assays, Biological materials, Protein/peptides
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