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Discovery of Well Defined Sulfated Glycopolymers as Specific Heparanase Inhibitors for Cancer Therapeutics

The remodeling of the extracellular matrix has been shown to be highly upregulated in cancer and inflammation and is critically linked to the processes of invasion and metastasis. The finding that heparanase is elevated in a wide variety of tumor types and is subsequently linked to the development of pathological processes has led to an explosion of...

Published: 12/2/2020 | Inventor(s): Hein Nguyen, Ravi Loka, Eric Sletten, Israel Vlodavsky

Keywords(s): Cancer, Cancer Therapies, Pharmaceuticals, Therapeutics

Category(s): Life Science, Oncology, Pharmaceuticals, Therapeutics

Targeted Drug Delivery for Spinal Cord Injury

Technology Summary: WSU researchers have developed a new nanoparticle-drug conjugate for treating cervical spinal cord injury (SCI) that can restore respiratory function to the paralyzed hemi diaphragm. Using the nano-conjugate enables targeted delivery of the drug directly to the respiratory centers resulting in dramatically lower effective dosages...

Published: 6/10/2025 | Inventor(s): Harry Goshgarian, Guangzhao Mao, Yi Zou, Sunxi Wang

Keywords(s): Central Nervous System, Drug Delivery, Neuroscience, Therapeutics

Category(s): Therapeutics, Life Science, Drug Delivery, Medical, Chemical Processing/Systhesis, Nanomaterials, Neurological disorders, Receptors/targets