Search Results - drug delivery

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An in vivo QQ-systemic protein delivery technology and applications

BackgroundThis invention contains a new composition of our researchers’ previously patented QQ-protein delivery technology and the in vivo applications of this protein delivery technology via systemic administered proteins for cancer diagnosis and therapy. Many proteins and peptides are used as highly specific and effective therapeutic agent...

Published: 8/3/2017 | Inventor(s): Jianjun Wang, Qianqian Li, Quan Jiang, Feng Jiang, Michael Chopp

Keywords(s): Cancer Therapies, Drug Delivery

Category(s): Diagnostics, Drug Delivery, Life Science, Oncology, Research tools, Therapeutics

A protein-induced In situ cell-conversion technology and applications

BackgroundCell reprogramming and trans-differentiation are techniques that convert somatic cells of individuals into either stem cells, including embryonic and adult stem cells (reprogramming) or the other type of somatic cells (trans-differentiation). These techniques are usually performed in the cell culture settings using viral gene delivery an...

Published: 8/3/2017 | Inventor(s): Jianjun Wang, Qianqian Li, Feng Jiang, Michael Chopp, Guojun Wu

Keywords(s): Cancer Therapies, Drug Delivery

Category(s): Drug Delivery, Life Science, Research tools

Targeted Drug Delivery for Spinal Cord Injury

Technology Summary: WSU researchers have developed a new nanoparticle-drug conjugate for treating cervical spinal cord injury (SCI) that can restore respiratory function to the paralyzed hemi diaphragm. Using the nano-conjugate enables targeted delivery of the drug directly to the respiratory centers resulting in dramatically lower effective dosag...

Published: 5/19/2017 | Inventor(s): Harry Goshgarian, Guangzhao Mao, Yi Zou, Sunxi Wang

Keywords(s): Central Nervous System, Drug Delivery, Neuroscience, Therapeutics

Category(s): Therapeutics, Life Science, Drug Delivery, Medical, Chemical Processing/Systhesis, Nanomaterials, Neurological disorders, Receptors/targets

Co-polymer Stabilizers for Pressured Metered Dose Inhalers (pMDIs)

A series of novel co polymer surfactants with the general structure LAmEOnLAm were developed along with a Colloidal Probe Microscopy (CPM) method to optimize the surfactant composition using adhesion forces to improve stabilization of drug dispersions. This expands the range of biomolecules and micronized drug particles that can be formulated with ...

Published: 8/14/2013 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Assay, Asthma, Compound, Device, Drug Delivery, Formulation, Instrumentation, Method, Pharmaceuticals, Process, Therapeutics

Category(s): Chemicals, Drug Delivery, Pharmaceuticals, Instrumentation, Materials

Nanoparticle Method to Stabilize Suspension-Based pMDI HFA Formulations

Novel nanoparticle-based drug compositions and methods that improve and expand therapeutic drug delivery to the lungs through pressurized meter-dose inhalers (pMDIs). A large variety of approaches have been developed at WSU aimed at improving the aerosol characteristics and expanding the range of target species deliverable. These improved formulati...

Published: 4/23/2013 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Asthma, Drug Delivery, Formulation, Nanomaterials, Pharmaceuticals

Category(s): Drug Delivery, Life Science, Nano-based, Therapeutics

Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases

Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC...

Published: 9/10/2012 | Inventor(s): David Oupicky, Jing Li

Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals

GlyB4 Fusion with Neuregulin Heparin-Targeting Domain to Block Neuregulin Signaling

We have harnessed this natural targeting ability of NRG by fusing the HBD of NRG to soluble HER4. This fusion protein retains high affinity heparin binding to heparin and to cells that express heparan sulfates resulting in a more potent NRG antagonist. In vivo, it is targeted to peripheral nerve segments where it blocks the activity of NRG as a Sch...

Published: 5/16/2011 | Inventor(s): Jeffrey Loeb, Qunfang Lee

Keywords(s): Anti-cancer, Biotechnology, Cancer risk, Cancer Therapies, Drug Delivery, Drug Target, Epilepsy

Category(s): Life Science, Drug Delivery, Other

Visual Prostheses Based Upon Fiber-Optic Uncaging of Neurotransmitter Substances

This drug delivery system selectively delivers drugs to various types of neurological cells to stimulate neurological tissue. This system can be used to develop visual and cortical prostheses. Background & Unmet Need: There are several types of prosthetic devices used for stimulation of neural tissue or neurons. There are visual prostheses us...

Published: 5/18/2010 | Inventor(s): Patrick Mcallister, Raymond Iezzi, Gregory Auner, Gary Abrams

Keywords(s): Drug Delivery, Neurological, Neuroscience

Category(s): Life Science, Neurological disorders, Therapeutics, Drug Delivery, Diseases

Nanometer-Sized Drug Delivery Devices (Nanoparticles) that Demonstrate High Encapsulation Efficiency and Sustained Release of Water-Soluble Drugs and their Preparation

This technology is a nano‑meter size drug delivery system that is capable of encapsulating water‑soluble drugs with high efficiency, allowing sustained release of the drug in the body. Background & Unmet Need: There are a number of biological barriers to cellular drug delivery. Simple diffusion across the cell membrane is feasibl...

Published: 5/7/2010 | Inventor(s): Jayanth Panyam, Mahesh Chavanpatil

Keywords(s): Drug Delivery, Nanomaterials

Category(s): Drug Delivery, Life Science, Nanomaterials, Therapeutics

New Immunotherapies for Cancer

Background Wayne State University researchers have developed a novel strategy to fight cancer and eradicate tumors through stimulation of the immune system. Curing cancer via the activation of patients’ immune system is considered an ideal strategy due to the potentially high potency and specificity of the human immune system to eradicate tum...

Published: 5/6/2010 | Inventor(s): Zhongwu Guo, Qianli Wang, Shouchu Tang

Keywords(s): Cancer Therapies, Drug Delivery, Pharmaceuticals, Therapeutics, Vaccines

Category(s): Therapeutics, Life Science, Diseases, Oncology

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