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Search Results - cancer
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Discovery of Well Defined Sulfated Glycopolymers as Specific Heparanase Inhibitors for
Cancer
Therapeutics
The remodeling of the extracellular matrix has been shown to be highly upregulated in
cancer
and inflammation and is critically linked to the processes of invasion and metastasis. The finding that heparanase is elevated in a wide variety of tumor types and is subsequently linked to the development of pathological processes has led to an explosion of...
Published: 12/2/2020
|
Inventor(s):
Hein Nguyen
,
Ravi Loka
,
Eric Sletten
,
Israel Vlodavsky
Keywords(s):
Cancer
,
Cancer
Therapies
,
Pharmaceuticals
,
Therapeutics
Category(s):
Life Science
,
Oncology
,
Pharmaceuticals
,
Therapeutics
A method to induce ferroptosis and to downregulate androgen receptor/androgen receptor splice variant in prostate
cancer
cells
Prostate
cancer
(PCa) effects approximately three million men in the United States every year. About 10-20% of the cases of prostate cancer are castrate-resistant prostate cancer (CRPC). This form of PCa is highly resistant to what Is known as androgen depletion therapy and is often fatal. All types of PCa are sensitive to androgen receptor signaling...
Published: 12/18/2024
|
Inventor(s):
Zhihui Qin
,
Liping Xu
Keywords(s):
Anti-
cancer
,
Cancer
,
Cancer
Therapies
,
Drug Delivery
,
Drug Target
,
Prostate
Cancer
Category(s):
Medical
,
Diseases
,
Drug Discovery
,
Pharmaceuticals
,
Oncology
Ruthenium-based caging of nitrile-containing enzyme inhibitors
Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the pathophysiology...
Published: 10/27/2023
|
Inventor(s):
Jeremy Kodanko
,
Claudia Turro
Keywords(s):
Cancer
,
Pharmaceuticals
Category(s):
Chemicals
,
Drug Delivery
,
Life Science
,
Physical Sciences
,
Other
A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in
Cancer
Tissue
This invention is a new and simple method for the identification of active versus latent matrix metalloprotease enzymes (MMPs) in tissue. Background & Unmet Need: MMPs are involved in tumor progression and therefore are targets for anti-
cancer
drug therapies. However, most drug therapies directed at inhibition of MMPs have failed because there...
Published: 11/22/2021
|
Inventor(s):
Avraham Raz
,
Rafael Fridman
,
Pratima Nangia-Makker
Keywords(s):
Biomarker
,
Cancer
,
Diagnostics
,
Enzyme
,
Method
Category(s):
Life Science
,
Oncology
,
Research tools
,
Antibodies
,
Therapeutics
,
Diseases