Search Results - method

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Co-polymer Stabilizers for Pressured Metered Dose Inhalers (pMDIs)

A series of novel co polymer surfactants with the general structure LAmEOnLAm were developed along with a Colloidal Probe Microscopy (CPM) method to optimize the surfactant composition using adhesion forces to improve stabilization of drug dispersions. This expands the range of biomolecules and micronized drug particles that can be formulated with pMDIs....

Published: 11/11/2021 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Assay, Asthma, Compound, Device, Drug Delivery, Formulation, Instrumentation, Method, Pharmaceuticals, Process, Therapeutics

Category(s): Chemicals, Drug Delivery, Pharmaceuticals, Instrumentation, Materials

Method to Produce Immunostimulatory Proteins and Tether Them to the Membrane of Enveloped Virus Vaccines

This technology is a method to produce immunostimulatory cytokine proteins and tether them to the membrane of enveloped virus vaccines produced in cell culture in order to improve vaccine efficacy. Background & Unmet Need: The successful elimination of pathogens following immunization depends on the ability of the host's immune system to become...

Published: 3/2/2022 | Inventor(s): Roy Sundick, Paul Roberts, Yufang Yang

Keywords(s): Method, Vaccines, Virus

Category(s): Therapeutics, Life Science, Vaccines

A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue

This invention is a new and simple method for the identification of active versus latent matrix metalloprotease enzymes (MMPs) in tissue. Background & Unmet Need: MMPs are involved in tumor progression and therefore are targets for anti-cancer drug therapies. However, most drug therapies directed at inhibition of MMPs have failed because there...

Published: 11/22/2021 | Inventor(s): Avraham Raz, Rafael Fridman, Pratima Nangia-Makker

Keywords(s): Biomarker, Cancer, Diagnostics, Enzyme, Method

Category(s): Life Science, Oncology, Research tools, Antibodies, Therapeutics, Diseases

Sub-monolayer detection with surface selective vibrational spectroscopy

This invention describes a new system and method for performing surface-selective spectroscopic detection with high sensitivity and low detection limits particularly in the visible and fingerprint mid-infrared spectral regions. The method offers a substantial improvement, 10-fold or more, over existing techniques. This invention has already been reduced...

Published: 11/11/2021 | Inventor(s): Alexander Benderskii, Igor Stiopkin, Himali Jayathilake

Keywords(s): Device, Instrumentation, Method, Nanotechnology, Optical, Photonic

Category(s): Instrumentation, Spectroscopy, Physical Sciences

Imaging Tandem Mass Spectrometry: Reduction to Practice

Currently, tandem mass spectrometry is typically performed by selecting a single mass peak in a time of flight or quadrupole mass spectrometer, which is then fragmented through collision, after which the products are mass-selected in a quadrupole or similar secondary mass spectrometer. A Wayne State University researcher has developed an alternative...

Published: 5/19/2017 | Inventor(s): Arthur Suits, Myung Kim, Brian Leskiw

Keywords(s): Diagnostics, Instrumentation, Method

Category(s): Instrumentation, Physical Sciences, Spectroscopy, Imaging, Other