Search Results - rafael fridman




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Inhibitors of Matrix Metalloproteinases
Wayne State University researchers and academic collaborators have prepared the first reported mechanism-based inhibitors for matrix metalloproteinases (MMPs). One of the novel compounds (SB-3CT) shows selectivity for the gelatinases (two members of the MMP family), which have been implicated in various pathological conditions including, but not...
Published: 6/22/2010   |   Inventor(s): Shahriar Mobashery, Rafael Fridman
Keywords(s):  
Category(s): Therapeutics, Life Science, Small molecule, Diseases
A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue
This invention is a new and simple method for the identification of active versus latent matrix metalloprotease enzymes (MMPs) in tissue. Background & Unmet Need: MMPs are involved in tumor progression and therefore are targets for anti-cancer drug therapies. However, most drug therapies directed at inhibition of MMPs have failed because there...
Published: 5/6/2010   |   Inventor(s): Avraham Raz, Rafael Fridman, Pratima Nangia-Makker
Keywords(s): Biomarker, Cancer, Diagnostics, Enzyme, Method
Category(s): Life Science, Oncology, Research tools, Antibodies, Therapeutics, Diseases