Search Results - enzyme

2 Results

Sort By:

Inhibitors of the ubiquitin E3 ligase BCA2 as anti-cancer therapeutic agents

Background:Breast cancer associated protein 2 (BCA2) is a ubiquitin E3 ligase found in invasive breast cancer. Studies have shown that by decreasing its activity, breast cancer cell growth and invasiveness are diminished. Targeting this ligase and inhibiting its activity could play a role in treatment of breast cancer. A molecular approach to inhibiting...

Published: 3/12/2018 | Inventor(s): Angelika Burger, Andrew Westwell

Keywords(s): Analog or Analogue, Breast Cancer, Cancer, Disease, Drug Target, Enzyme

Category(s): Diseases, Oncology, Therapeutics, Life Science, Research tools

A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue

This invention is a new and simple method for the identification of active versus latent matrix metalloprotease enzymes (MMPs) in tissue. Background & Unmet Need: MMPs are involved in tumor progression and therefore are targets for anti-cancer drug therapies. However, most drug therapies directed at inhibition of MMPs have failed because there...

Published: 11/22/2021 | Inventor(s): Avraham Raz, Rafael Fridman, Pratima Nangia-Makker

Keywords(s): Biomarker, Cancer, Diagnostics, Enzyme, Method

Category(s): Life Science, Oncology, Research tools, Antibodies, Therapeutics, Diseases