Search Results - biomarker

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ERK-Mediated Grb7 Phosphorylation: A Biomarker and Potential Therapeutic Target in Her2/Grb7 Amplified Cancers

This invention is a new bio-marker for breast and other cancers that have Her2 and Grb7 gene amplifications, thus providing a therapeutic intervention in Her2/Grb7 amplified cancers.Background40% of breast cancers, as well as several other cancer types, display increased activation of tyrosine kinases from the ErbB family, with Her2 found amplified...

Published: 3/12/2018 | Inventor(s): Guri Tzivion, Deborah Leicht, Alexander Kaplun, Stephen Ethier

Keywords(s): Biomarker, Biotechnology, Cancer, Cancer Therapies, Therapeutics

Category(s): Diagnostic, Life Science, Oncology

A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue

This invention is a new and simple method for the identification of active versus latent matrix metalloprotease enzymes (MMPs) in tissue. Background & Unmet Need: MMPs are involved in tumor progression and therefore are targets for anti-cancer drug therapies. However, most drug therapies directed at inhibition of MMPs have failed because there...

Published: 11/22/2021 | Inventor(s): Avraham Raz, Rafael Fridman, Pratima Nangia-Makker

Keywords(s): Biomarker, Cancer, Diagnostics, Enzyme, Method

Category(s): Life Science, Oncology, Research tools, Antibodies, Therapeutics, Diseases