Search Results - biomarker




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ERK-Mediated Grb7 Phosphorylation: A Biomarker and Potential Therapeutic Target in Her2/Grb7 Amplified Cancers
This invention is a new bio-marker for breast and other cancers that have Her2 and Grb7 gene amplifications, thus providing a therapeutic intervention in Her2/Grb7 amplified cancers.Background40% of breast cancers, as well as several other cancer types, display increased activation of tyrosine kinases from the ErbB family, with Her2 found amplified...
Published: 8/3/2017   |   Inventor(s): Guri Tzivion, Deborah Leicht, Alexander Kaplun, Stephen Ethier
Keywords(s): Biomarker, Biotechnology, Cancer, Cancer Therapies, Therapeutics
Category(s): Diagnostic, Life Science, Oncology
Biologically active ATP-Analogs for tagging phosphoproteins
A novel Photo Cross Linking Assay (PCLA) for targeting protein phosphorylation Protein phosphorylation catalyzed by kinases and phosphatases act at critical control points that regulates many cellular processes. This central role makes them an attractive target for identifying largely untapped and important biomarkers for disease diagnostics. Under...
Published: 5/11/2010   |   Inventor(s): Mary Pflum
Keywords(s): Assay, Biomarker, Protein
Category(s): Chemicals, Life Science, Research tools, Assays, Reagents
A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue
This invention is a new and simple method for the identification of active versus latent matrix metalloprotease enzymes (MMPs) in tissue. Background & Unmet Need: MMPs are involved in tumor progression and therefore are targets for anti-cancer drug therapies. However, most drug therapies directed at inhibition of MMPs have failed because there...
Published: 5/6/2010   |   Inventor(s): Avraham Raz, Rafael Fridman, Pratima Nangia-Maker
Keywords(s): Biomarker, Cancer, Diagnostics, Enzyme, Method
Category(s): Life Science, Oncology, Research tools, Antibodies, Therapeutics, Diseases