Search Results - prostate+cancer

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A method to induce ferroptosis and to downregulate androgen receptor/androgen receptor splice variant in prostate cancer cells

Prostate cancer (PCa) effects approximately three million men in the United States every year. About 10-20% of the cases of prostate cancer are castrate-resistant prostate cancer (CRPC). This form of PCa is highly resistant to what Is known as androgen depletion therapy and is often fatal. All types of PCa are sensitive to androgen receptor signaling...

Published: 10/26/2023 | Inventor(s): Zhihui Qin, Liping Xu

Keywords(s): Anti-cancer, Cancer, Cancer Therapies, Drug Delivery, Drug Target, Prostate Cancer

Category(s): Medical, Diseases, Drug Discovery, Pharmaceuticals, Oncology

Para-Amino Substituent on the D Ring of Green Tea Polyphenol Epigallocatechin-3-Gallate as Novel Proteasome Inhibitor and Cancer Apoptosis Inducer

This technology is a group of (-)EGCG analogs with stable and improved anti-tumor activities. Background & Unmet Need:Catechins are a type of plant-derived antioxidant whose biological activities may play an effect on cancer prevention. Green tea has long been lauded to have ingredients that protect cells from the DNA damage that causes cancer....

Published: 2/28/2022 | Inventor(s): Qingping Dou, Kristin Landis-Piwowar, Tak-Hang Chan, Kumi Osanai

Keywords(s): Anti-cancer, Breast Cancer, Compound, Prostate Cancer

Category(s): Life Science, Oncology, Therapeutics, Diseases

Establishment of a Prostate Carcinoma Bone Tumor Model in Mice

This technology is a new tumorigenic cell line from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/IF, when implanted in the femurs of nude mice, provide a xenograft tumor model of bone metastatic prostate carcinoma. The PC-3/IF cell lines are highly tumorigenic, with tumor cells replacing the marrow cells in the bone...

Published: 12/6/2022 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Prostate Cancer, Research Tool

Category(s): Animal models, Life Science, Research tools, Oncology, Diseases

Establishment of a Metastatic Prostate Carcinoma Tumor Model in Mice

This technology is a new tumorigenic cell line from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/PI, are highly tumorigenic when implanted in the prostate of nude mice, providing a xenograft tumor model of prostate carcinoma. In this model, lymph node metastases form from the primary tumor, similar to what occurs in...

Published: 9/16/2019 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Prostate Cancer, Research Tool

Category(s): Animal models, Life Science, Oncology, Research tools, Diseases