Search Results - anti-cancer




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Anti-Cancer Activity of a 2,5-Substituted Pyrimidine
This technology is a novel class of compounds that induce apoptosis in cancerous cells. BackgroundARR molecules (adamantyl-substituted retinoid-related) are a unique class of compounds which have been found to induce apoptosis, or cell death, in a large number of tumor types. SHP plays a role in cellular proliferation. Molecules that Interfere wi...
Published: 8/3/2017   |   Inventor(s): Joseph Fontana, Ramzi Mohammad, Lulu Farhana, Amro Aboukameel, Marcia Dawson, Zebin Xia
Keywords(s): Analog or Analogue, Anti-cancer
Category(s): Life Science, Oncology, Therapeutics, Diseases
Novel Anti-Cancer Therapeutic Strategy to Overcome Cancer Resistance and to Enable Tailoring Treatment
This technology is a gene therapy construct based on modified programmed-cell-death genes involved in intracellular apoptosis. Bypassing the main treatment-resistant mechanisms of cancer offers a new direction, away from broad-spectrum treatments, towards individualized therapies for cancer treatment that carry fewer side-effects. Background &...
Published: 8/3/2017   |   Inventor(s): Karli Rosner
Keywords(s): Anti-cancer, Cancer, Disease, Gene, Melanoma, Target, Therapeutics
Category(s): Life Science, Therapeutics, Diseases, Oncology, Biologicals, Genes
SH80 Combinations
BackgroundSH35/SH80 evolved from an effort to improve upon the anti-tumor activity of XK469. XK469 is a compound, currently in Phase 1 clinical trials. The clinical trials include patients with bladder, breast, colorectal, esophageal, head and neck, kidney, liver, lung, mesothelioma, pancreas and sarcoma cancers. Moving a chlorine atom from one ...
Published: 8/3/2017   |   Inventor(s): Lisa Polin
Keywords(s): Anti-cancer, Compound
Category(s): Life Science, Oncology, Therapeutics
Activated T Cells and Activated T Cells Armed with BiSpecific Antibodies Directed at Cancer Antigens are Poor Responders to Alloantigens May Help Engraftment and Improve Anti-Tumor Effects
BackgroundThe treatment of hematologic malignancies with allogeneic stem cell transplant is limited by the numbers of allogeneic donors. Umbilical cord blood stem transplants have been an important alternative source of hematopoietic stem cells. However, failure or delayed engraftment remains the critical barrier to the success of the transplants...
Published: 8/3/2017   |   Inventor(s): Lawrence Lum
Keywords(s): Anti-cancer
Category(s): Life Science, Therapeutics, Diseases, Infectious disease
Para-Amino Substituent on the D Ring of Green Tea Polyphenol Epigallocatechin-3-Gallate as Novel Proteasome Inhibitor and Cancer Apoptosis Inducer
This technology is a group of (-)EGCG analogs with stable and improved anti-tumor activities. Background & Unmet Need:Catechins are a type of plant-derived antioxidant whose biological activities may play an effect on cancer prevention. Green tea has long been lauded to have ingredients that protect cells from the DNA damage that causes cancer...
Published: 8/3/2017   |   Inventor(s): Qingping Dou, Kristin Landis-Piwowar, Tak-Hang Chan, Kumi Osanai
Keywords(s): Anti-cancer, Breast Cancer, Compound, Prostate Cancer
Category(s): Life Science, Oncology, Therapeutics, Diseases
Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors
Background: Often referred to as the crucial "drug discovery tool", cell based technology is one of the most significant sectors of pharmaceutical research and development. Of particular importance has been the development of information-rich cellular assays that determine drug candidate efficacy and safety (target identification, valida...
Published: 8/14/2013   |   Inventor(s): Leon Carlock, Maria Cypher
Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics
Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines
GlyB4 Fusion with Neuregulin Heparin-Targeting Domain to Block Neuregulin Signaling
We have harnessed this natural targeting ability of NRG by fusing the HBD of NRG to soluble HER4. This fusion protein retains high affinity heparin binding to heparin and to cells that express heparan sulfates resulting in a more potent NRG antagonist. In vivo, it is targeted to peripheral nerve segments where it blocks the activity of NRG as a Sch...
Published: 5/16/2011   |   Inventor(s): Jeffrey Loeb, Qunfang Lee
Keywords(s): Anti-cancer, Biotechnology, Cancer risk, Cancer Therapies, Drug Delivery, Drug Target, Epilepsy
Category(s): Life Science, Drug Delivery, Other
Repurposing AKT Inhibitors for the Treatment of Protein Misfolding and Protein Trafficking Diseases
WSU researchers have generated a reagent to understand the degenerative processes occurring in Pelizaeus‑Merzbacher disease (PMD) and to study the intracellular signaling that occurs because of these diseased processes. They have deduced that the use of AKT inhibitors may reduce disease severity in patients with a wide range of degenerative ...
Published: 6/22/2010   |   Inventor(s): Alexander Gow, Cherie Southwood
Keywords(s): Alzheimer's Disease, Anti-cancer, Neuro-disorders, Parkinson's
Category(s): Life Science, Neurological disorders, Therapeutics, Diseases
Hox B4
This invention is a novel therapy for cancer using Hox B4 to induce apoptosis in leukemia cell lines. Background & Unmet Need: B‑cell chronic lymphocytic leukemia is the most common type of leukemia in adults. The B cells grow uncontrollably and invade the bone marrow and blood where they crowd out the healthy cells. There is a need to...
Published: 5/18/2010   |   Inventor(s): Kamal Mubarak, Ramzi Mohammad, Robert Pauley, Larry Tait
Keywords(s): Anti-cancer, Gene, Protein
Category(s): Therapeutics, Life Science, Oncology, Diseases
Method For Treating and/or Imaging Breast Cancer Using Radioactive Iodine
This invention involves treating a breast cancer patient by the administration of a radioisotope of iodine in a dosage of between 5 and 50 milliCuries over the course of a day. The therapeutic composition is designed for mammary tissue uptake and includes an inorganic radioactive iodide salt (e.g., alkali metal, alkali earth or transition met...
Published: 5/18/2010   |   Inventor(s): James Rillema
Keywords(s): Anti-cancer, Breast Cancer, Cancer Therapies, Imaging, Therapeutics
Category(s): Therapeutics, Life Science, Oncology, Receptors/targets, Diagnostic, Imaging