Search Results - pharmaceuticals

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Co-polymer Stabilizers for Pressured Metered Dose Inhalers (pMDIs)

A series of novel co polymer surfactants with the general structure LAmEOnLAm were developed along with a Colloidal Probe Microscopy (CPM) method to optimize the surfactant composition using adhesion forces to improve stabilization of drug dispersions. This expands the range of biomolecules and micronized drug particles that can be formulated with ...

Published: 8/14/2013 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Assay, Asthma, Compound, Device, Drug Delivery, Formulation, Instrumentation, Method, Pharmaceuticals, Process, Therapeutics

Category(s): Chemicals, Drug Delivery, Pharmaceuticals, Instrumentation, Materials

Ruthenium-based caging of nitrile-containing enzyme inhibitors

Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the p...

Published: 4/29/2013 | Inventor(s): Jeremy Kodanko, Claudia Turro

Keywords(s): Cancer, Pharmaceuticals

Category(s): Chemicals, Drug Delivery, Life Science, Physical Sciences, Other

Nanoparticle Method to Stabilize Suspension-Based pMDI HFA Formulations

Novel nanoparticle-based drug compositions and methods that improve and expand therapeutic drug delivery to the lungs through pressurized meter-dose inhalers (pMDIs). A large variety of approaches have been developed at WSU aimed at improving the aerosol characteristics and expanding the range of target species deliverable. These improved formulati...

Published: 4/23/2013 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Asthma, Drug Delivery, Formulation, Nanomaterials, Pharmaceuticals

Category(s): Drug Delivery, Life Science, Nano-based, Therapeutics

Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases

Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC...

Published: 9/10/2012 | Inventor(s): David Oupicky, Jing Li

Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals

New Immunotherapies for Cancer

Background Wayne State University researchers have developed a novel strategy to fight cancer and eradicate tumors through stimulation of the immune system. Curing cancer via the activation of patients’ immune system is considered an ideal strategy due to the potentially high potency and specificity of the human immune system to eradicate tum...

Published: 5/6/2010 | Inventor(s): Zhongwu Guo, Qianli Wang, Shouchu Tang

Keywords(s): Cancer Therapies, Drug Delivery, Pharmaceuticals, Therapeutics, Vaccines

Category(s): Therapeutics, Life Science, Diseases, Oncology

Improved pDMI Inhaler Formulations

Novel biodegradable, non-toxic nanoparticles that act as stabilizing excipients with a wide variety of suspension drug candidates including polar & non-polar drug particles, bio-macromolecules (proteins/peptides), gene therapies (DNA/siRNA) as well as amorphous and crystalline therapeutics have been developed which provide a platform for improv...

Published: 5/6/2010 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Asthma, Drug Delivery, Formulation, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Life Science, Therapeutics, Nano-based