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CMOS Laddered Inverter Ring Oscillator
​​Low-Power, Multi-Phase, CMOS-based Ring Oscillator Circuit Background: CMOS technology is used for constructing integrated circuit (IC) chips, including microprocessors, microcontrollers, memory chips (including CMOS BIOS), and other analog and digital logic circuits. A CMOS ring oscillator circuit is an odd number (N) of inverting stages connected...
Published: 10/19/2021   |   Inventor(s): Melvin Edwards II, Mohammad Alhawari
Keywords(s): IoT
Category(s): Communications, Physical Sciences, Electronics, Electrical
Discovery of Well Defined Sulfated Glycopolymers as Specific Heparanase Inhibitors for Cancer Therapeutics
The remodeling of the extracellular matrix has been shown to be highly upregulated in cancer and inflammation and is critically linked to the processes of invasion and metastasis. The finding that heparanase is elevated in a wide variety of tumor types and is subsequently linked to the development of pathological processes has led to an explosion of...
Published: 12/2/2020   |   Inventor(s): Hein Nguyen, Ravi Loka, Eric Sletten, Israel Vlodavsky
Keywords(s): Cancer, Cancer Therapies, Pharmaceuticals, Therapeutics
Category(s): Life Science, Oncology, Pharmaceuticals, Therapeutics
A method to induce ferroptosis and to downregulate androgen receptor/androgen receptor splice variant in prostate cancer cells
Prostate cancer (PCa) effects approximately three million men in the United States every year. About 10-20% of the cases of prostate cancer are castrate-resistant prostate cancer (CRPC). This form of PCa is highly resistant to what Is known as androgen depletion therapy and is often fatal. All types of PCa are sensitive to androgen receptor signaling...
Published: 11/19/2020   |   Inventor(s): Zhihui Qin, Liping Xu
Keywords(s): Anti-cancer, Cancer, Cancer Therapies, Drug Delivery, Drug Target, Prostate Cancer
Category(s): Medical, Diseases, Drug Discovery, Pharmaceuticals, Oncology
Identification of Galeterone's mechanism of action leading to novel treatment therapies for castrate resistant prostate cancer (CRPC)
Castration-Resistant Prostate Cancer (CRPC) or Hormone Refractory Prostate Cancer (HRPC), is a type of prostate cancer that typically recurs after administering androgen deprivation therapy (ADT). The need for effective therapies for these difficult to treat cancers is gaining prominence in the prostate cancer market. The global CRPC market is poised...
Published: 11/19/2020   |   Inventor(s): Qingping Dou, Huanjie Yang, Elisabeth Heath
Keywords(s):  
Category(s): Life Science, Oncology, Pharmaceuticals, Receptors/targets, Process/Procedure, Small molecule, Therapeutics
Fc-folate conjugate for the treatment of triple negative breast cancer
Approximately 13% of women in the United States will develop breast cancer according to the American Cancer Society. That makes breast cancer the second leading cause of cancer death in women right behind lung cancer. Triple negative breast cancer (TNBC) represents about 10 – 20% of all breast cancers. Triple negative refers to cancer cells...
Published: 11/19/2020   |   Inventor(s): Cecilia Speyer
Keywords(s): Anti-cancer, Breast Cancer, Cancer, Cancer Therapies
Category(s): Antibodies, Assays, Biology, Biomedical, Chemical Processing/Synthesis, Diseases, Drug Delivery, Life Science, Oncology, Protein/peptides, Receptors/targets, Small molecule, Therapeutics
Ultra-Specific and Ultra-Sensitive Platform for Highly-Reliable and High-Precision SARS-CoV-2 Detection
Background:The technology described is based on the use of two unique sets of detection molecules that are specific to a protein contained in the viral shell of SARS CoV-2 and Covid-19 that is unique from other known common cold causing coronaviruses. The proposed system uses two different fluorescent probes for two different regions of the viral shell...
Published: 5/26/2020   |   Inventor(s): Rodrigo Fernandez-Valdivia
Keywords(s): Coronavirus, COVID-19, Diagnostic, Virus
Category(s): Diagnostic, Biomedical, Medical, Diseases, Infectious disease
Disulfide by Design 2.0: A web-based tool for disulfide engineering in proteins
Background:Immunoinformatics employs a computer-driven approach to identifying fragments of the target pathogen that would provide a suitable vaccine, avoiding potential safety concerns from the more traditional approach of using whole pathogens. Immunoinformatics now plays a crucial role in vaccine design, immunodiagnostic development, and antibody...
Published: 4/29/2020   |   Inventor(s): Alan Dombkowski, Douglas Craig
Keywords(s): Coronavirus, COVID-19
Category(s): Life Science, Software, Simulation & Modeling, Research tools, Computer Software, Protein/peptides
Microfluidic platforms for live-cell imaging and bio/pathomimetic tissue models
Background:Methodologies to image and quantify tissue models using high-content analysis (HCI) and functional analyses of 3D avatars are needed as such avatars better recapitulate the phenotype of pathobiological processes and better predict efficacy of, and resistance to, a wide variety of therapies. Furthermore, changes in morphometry, viability,...
Published: 4/6/2020   |   Inventor(s): Bonnie Sloane, Kamiar Moin, Kyungmin Ji, Kingsley Osuala, Yong Xu, Hongen Tu
Keywords(s):  
Category(s): Specialty compounds, Research tools, Oncology, Microfluidics, Life Science, Instrumentation, Imaging, Diseases, Devices, Cell lines
SALT-FORMULATED VALPROATE AS A TOPICAL ANTI-FUNGAL TREATMENT
In 2018, the global antifungal drugs market size was valued at USD 11.6 billion. Generally speaking, 54.3% of sales are prescription and 45.7% is over-the counter OTC/Alternative. It is anticipated that the OTC/Alternative portion of the global antifungal market will continue to grow. Science is indicating that both the number of systemic infections...
Published: 4/6/2020   |   Inventor(s): Miriam Greenberg, Rania Deranieh
Keywords(s):  
Category(s): Diseases, Infectious disease, Life Science, Small molecule, Pharmaceuticals
Polyclonal and Monoclonal Antibodies to TPH1 and TPH2
This technology is a set of antibodies that is used with immunohistochemistry techniques to differentiate between tryptophan hydroxylase 1 and 2, enabling scientists to study how the two enzymes are differentially regulated. Background & Unmet Need: The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode enzymes in serotonin biosynthesis....
Published: 12/4/2019   |   Inventor(s): Donald Kuhn
Keywords(s): Antibody, Assay, Immunoassay
Category(s): Life Science, Research tools, Biological materials, Antibodies
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