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Multi-parametric Acoustic, Optical and Mechanical Imaging of Cervical Tissue Insufficiencies to Predict Preterm Birth
An enhanced image-guidance system that integrates ultrasound and photoacoustic into existing ablation systems to provide an enhanced image-guidance system for identification of cervical tissue changes during pregnancy and postpartum.
Technology Summary
Preterm delivery is a main cause of perinatal morbidity and mortality worldwide, which is associated...
Published: 9/15/2025
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Inventor(s): Mohammad Mehrmohammadi, Sonia Hassan, Edgar Hernandez-Andrade, Yan Yan, Maryam Basij
Keywords(s): Driving Lifelong Health
Category(s): Technology Category > Women's Health, Technology Category > Medical Devices, Technology Category > Life Science, Technology Category > Imaging, Technology Category > Acoustics
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Using Nanotechnology to Target Aggressive Cancers
A modified gold nanoparticle is used to target aggressive triple negative breast cancer and melanoma by inhibiting RAD6 which is overexpressed in aggressive and chemoresistant cancers.
Technology Summary
This technology utilizes gold nanoparticles (GNPs) conjugated with a small molecule inhibitor (SMI#9) designed to target RAD6, a protein overexpressed...
Published: 9/15/2025
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Inventor(s): Malathy Shekhar, Guangzhao Mao, Yanhua Zhang
Keywords(s): Breast Cancer, Nanotechnology
Category(s): Technology Category > Therapeutics, Technology Category > Oncology, Technology Category > Nanomaterials, Technology Category > Life Science, Technology Category > Drug Delivery, Technology Category > Cancer
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Imaging Tandem Mass Spectrometry: Reduction to Practice
Currently,
tandem mass spectrometry is typically performed by selecting a single mass peak
in a time of flight or quadrupole mass spectrometer, which is then fragmented
through collision, after which the products are mass-selected in a quadrupole or
similar secondary mass spectrometer. A Wayne State University researcher has
developed an alternative...
Published: 9/15/2025
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Inventor(s): Arthur Suits, Myung Kim, Brian Leskiw
Keywords(s): Diagnostics, Instrumentation, Method
Category(s): Technology Category > Spectroscopy, Technology Category > Physical Sciences, Technology Category > Other, Technology Category > Instrumentation, Technology Category > Imaging
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Wearable Ear Sensor for continuous health monitoring.
WSU researchers have developed an ultrasmall, low power technology to sense heart rate, pulse wave velocity (PWV), blood
oxygenation and blood pressure. The device uses a digital optical proximity sensor (OPS) which integrates LED light sources, detectors
and signal processors into a 4mm square and consumes <200 microwatts, which represents a 10X...
Published: 9/15/2025
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Inventor(s): Amar Basu
Keywords(s):
Category(s): Technology Category > Sensors, Technology Category > Medical Devices, Technology Category > Life Science, Technology Category > Electronics, Technology Category > Bioengineering
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CMOS Laddered Inverter Ring Oscillator
Low-Power, Multi-Phase, CMOS-based Ring Oscillator Circuit
Background:
CMOS technology is used for constructing integrated circuit (IC) chips, including microprocessors, microcontrollers, memory chips (including CMOS BIOS), and other analog and digital logic circuits. A CMOS ring oscillator circuit is an odd number (N) of inverting stages connected...
Published: 9/15/2025
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Inventor(s): Melvin Edwards II, Mohammad Alhawari
Keywords(s): IoT
Category(s): Technology Category > Physical Sciences, Technology Category > Electronics, Technology Category > Electrical, Technology Category > Communications
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Discovery of Well Defined Sulfated Glycopolymers as Specific Heparanase Inhibitors for Cancer Therapeutics
The remodeling of the extracellular matrix has been shown to be highly upregulated in cancer and inflammation and is critically linked to the processes of invasion and metastasis. The finding that heparanase is elevated in a wide variety of tumor types and is subsequently linked to the development of pathological processes has led to an explosion of...
Published: 9/15/2025
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Inventor(s): Hien Nguyen, Ravi Loka, Eric Sletten, Israel Vlodavsky
Keywords(s): Cancer, Cancer Therapies, Pharmaceuticals, Therapeutics
Category(s): Technology Category > Therapeutics, Technology Category > Pharmaceuticals, Technology Category > Oncology, Technology Category > Life Science
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A method to induce ferroptosis and to downregulate androgen receptor/androgen receptor splice variant in prostate cancer cells
Prostate cancer (PCa) effects approximately three million men in the United States every year. About 10-20% of the cases of prostate cancer are castrate-resistant prostate cancer (CRPC). This form of PCa is highly resistant to what Is known as androgen depletion therapy and is often fatal. All types of PCa are sensitive to androgen receptor signaling...
Published: 9/15/2025
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Inventor(s): Zhihui Qin, Liping Xu
Keywords(s): Anti-cancer, Cancer, Cancer Therapies, Drug Delivery, Drug Target, Prostate Cancer
Category(s): Technology Category > Pharmaceuticals, Technology Category > Oncology, Technology Category > Medical, Technology Category > Drug Discovery, Technology Category > Diseases
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Identification of Galeterone's mechanism of action leading to novel treatment therapies for castrate resistant prostate cancer (CRPC)
Castration-Resistant Prostate Cancer (CRPC) or Hormone Refractory Prostate Cancer (HRPC), is a type of prostate cancer that typically recurs after administering androgen deprivation therapy (ADT). The need for effective therapies for these difficult to treat cancers is gaining prominence in the prostate cancer market. The global CRPC market is poised...
Published: 9/15/2025
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Inventor(s): Qingping Dou, Huanjie Yang, Elisabeth Heath
Keywords(s):
Category(s): Technology Category > Therapeutics, Technology Category > Small molecule, Technology Category > Receptors/targets, Technology Category > Process/Procedure, Technology Category > Pharmaceuticals, Technology Category > Oncology, Technology Category > Life Science
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Ultra-Specific and Ultra-Sensitive Platform for Highly-Reliable and High-Precision SARS-CoV-2 Detection
Background:The technology described is based on the use of two unique sets of detection molecules that are specific to a protein contained in the viral shell of SARS CoV-2 and Covid-19 that is unique from other known common cold causing coronaviruses. The proposed system uses two different fluorescent probes for two different regions of the viral shell...
Published: 9/15/2025
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Inventor(s): Rodrigo Fernandez-Valdivia
Keywords(s): Coronavirus, COVID-19, Diagnostic, Virus
Category(s): Technology Category > Medical, Technology Category > Infectious disease, Technology Category > Diseases, Technology Category > Diagnostic, Technology Category > Biomedical
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Disulfide by Design 2.0: A web-based tool for disulfide engineering in proteins
Background:Immunoinformatics employs a computer-driven approach to identifying fragments of the target pathogen that would provide a suitable vaccine, avoiding potential safety concerns from the more traditional approach of using whole pathogens. Immunoinformatics now plays a crucial role in vaccine design, immunodiagnostic development, and antibody...
Published: 9/15/2025
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Inventor(s): Alan Dombkowski, Douglas Craig
Keywords(s): Coronavirus, COVID-19
Category(s): Technology Category > Software, Technology Category > Simulation & Modeling, Technology Category > Research tools, Technology Category > Protein/peptides, Technology Category > Life Science, Technology Category > Computer Software
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