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Methods For The Prediction Of Drug Penetration and Exposure In The Human Brain
Description:
A novel 9‑compartment physiologically based pharmacokinetic model that predicts drug distribution and exposure in the human brain and brain tumors to improve treatment outcomes. SpatialCNS-PBPK is an advanced, web-based platform implementing a 9-compartment PBPK model that simulates spatial pharmacokinetics of drugs within the central...
Published: 11/6/2025
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Inventor(s): Jing Li, Seongho Kim, Charuka Wickramasinghe
Keywords(s):
Category(s): Technology Category > Life Science, Technology Category > Method, Technology Category > Drug Screening, Technology Category > Drug Delivery
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Method for Constructing a Lateral Material Sourcing Database
Description:
This technology revolutionizes traditional supply chains by focusing on hyperlocal sourcing of materials typically overlooked or discarded within communities. Using advanced AI to analyze public and contextual data alongside geographic information—such as addresses, coordinates, and regional identifiers, the tool identifies novel...
Published: 11/6/2025
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Inventor(s): Kwame Robinson
Keywords(s):
Category(s): Technology Category > AI (Artificial Intelligence), Technology Category > Data Storage & Security, Technology Category > Physical Sciences, Technology Category > Software
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Thermal Atomic Layer Etching of Cobalt and Other Transition Metal Films
A novel stepwise chemical etching method for precise and controlled removal of metal surfaces using protic compounds.
Technology Summary
This technology introduces a method for etching metal or element surfaces by initially contacting the surface with a protic compound to create a modified layer, followed by exposure to a protic ligand-forming compound...
Published: 10/28/2025
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Inventor(s): Charles Winter
Keywords(s):
Category(s): Technology Category > Assays, Technology Category > Chemical Processing/Synthesis, Technology Category > Chemicals, Technology Category > Life Science, Technology Category > Materials, Technology Category > Physical Sciences, Technology Category > Physics, Technology Category > Process/Procedure, Technology Category > Small molecule, Technology Category > Specialty compounds, Technology Category > Thin films
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High Capacity Hybrid Frame-Wall Intended for Cold-formed Steel Construction
High-Capacity Hybrid Frame-Wall Intended for Cold-formed Steel Construction
WSU Tech#: 23-1735
Technology Summary
This innovative hybrid frame-wall system integrates cold formed steel columns that support gravitational loads with a steel braced frame embedded within the wall plane to resist lateral forces. The frame uses concentric and eccentric...
Published: 10/24/2025
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Inventor(s): Fatmir Menkulasi, Salih Rakici
Keywords(s):
Category(s): Technology Category > Physical Sciences, Technology Category > Building & Construction, Technology Category > Engineering
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Multi-parametric Acoustic, Optical and Mechanical Imaging of Cervical Tissue Insufficiencies to Predict Preterm Birth
An enhanced image-guidance system that integrates ultrasound and photoacoustic into existing ablation systems to provide an enhanced image-guidance system for identification of cervical tissue changes during pregnancy and postpartum.
Technology Summary
Preterm delivery is a main cause of perinatal morbidity and mortality worldwide, which is associated...
Published: 10/1/2025
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Inventor(s): Mohammad Mehrmohammadi, Sonia Hassan, Edgar Hernandez-Andrade, Yan Yan, Maryam Basij
Keywords(s): Driving Lifelong Health
Category(s): Technology Category > Women's Health, Technology Category > Medical Devices, Technology Category > Life Science, Technology Category > Imaging, Technology Category > Acoustics
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Using Nanotechnology to Target Aggressive Cancers
A modified gold nanoparticle is used to target aggressive triple negative breast cancer and melanoma by inhibiting RAD6 which is overexpressed in aggressive and chemo resistant cancers.
Technology Summary
This technology utilizes gold nanoparticles (GNPs) conjugated with a small molecule inhibitor (SMI#9) designed to target RAD6, a protein overexpressed...
Published: 9/26/2025
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Inventor(s): Malathy Shekhar, Guangzhao Mao, Yanhua Zhang
Keywords(s): Breast Cancer, Driving Lifelong Health, Nanotechnology
Category(s): Technology Category > Therapeutics, Technology Category > Oncology, Technology Category > Nanomaterials, Technology Category > Life Science, Technology Category > Drug Delivery, Technology Category > Cancer, Technology Category > Women's Health
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Wearable Ear Sensor for continuous health monitoring.
WSU researchers have developed an ultrasmall, low power technology to sense heart rate, pulse wave velocity (PWV), blood
oxygenation and blood pressure. The device uses a digital optical proximity sensor (OPS) which integrates LED light sources, detectors
and signal processors into a 4mm square and consumes <200 microwatts, which represents a 10X...
Published: 9/15/2025
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Inventor(s): Amar Basu
Keywords(s):
Category(s): Technology Category > Sensors, Technology Category > Medical Devices, Technology Category > Life Science, Technology Category > Electronics, Technology Category > Bioengineering
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CMOS Laddered Inverter Ring Oscillator
Low-Power, Multi-Phase, CMOS-based Ring Oscillator Circuit
Background:
CMOS technology is used for constructing integrated circuit (IC) chips, including microprocessors, microcontrollers, memory chips (including CMOS BIOS), and other analog and digital logic circuits. A CMOS ring oscillator circuit is an odd number (N) of inverting stages connected...
Published: 10/6/2025
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Inventor(s): Melvin Edwards II, Mohammad Alhawari
Keywords(s): IoT
Category(s): Technology Category > Physical Sciences, Technology Category > Electronics, Technology Category > Electrical, Technology Category > Communications
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Discovery of Well Defined Sulfated Glycopolymers as Specific Heparanase Inhibitors for Cancer Therapeutics
The remodeling of the extracellular matrix has been shown to be highly upregulated in cancer and inflammation and is critically linked to the processes of invasion and metastasis. The finding that heparanase is elevated in a wide variety of tumor types and is subsequently linked to the development of pathological processes has led to an explosion of...
Published: 9/15/2025
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Inventor(s): Hien Nguyen, Ravi Loka, Eric Sletten, Israel Vlodavsky
Keywords(s): Cancer, Cancer Therapies, Pharmaceuticals, Therapeutics
Category(s): Technology Category > Therapeutics, Technology Category > Pharmaceuticals, Technology Category > Oncology, Technology Category > Life Science
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A method to induce ferroptosis and to downregulate androgen receptor/androgen receptor splice variant in prostate cancer cells
Prostate cancer (PCa) effects approximately three million men in the United States every year. About 10-20% of the cases of prostate cancer are castrate-resistant prostate cancer (CRPC). This form of PCa is highly resistant to what Is known as androgen depletion therapy and is often fatal. All types of PCa are sensitive to androgen receptor signaling...
Published: 9/15/2025
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Inventor(s): Zhihui Qin, Liping Xu
Keywords(s): Anti-cancer, Cancer, Cancer Therapies, Drug Delivery, Drug Target, Prostate Cancer
Category(s): Technology Category > Pharmaceuticals, Technology Category > Oncology, Technology Category > Medical, Technology Category > Drug Discovery, Technology Category > Diseases
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