Search Results - biologicals




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Novel Anti-Cancer Therapeutic Strategy to Overcome Cancer Resistance and to Enable Tailoring Treatment
This technology is a gene therapy construct based on modified programmed-cell-death genes involved in intracellular apoptosis. Bypassing the main treatment-resistant mechanisms of cancer offers a new direction, away from broad-spectrum treatments, towards individualized therapies for cancer treatment that carry fewer side-effects. Background &...
Published: 8/3/2017   |   Inventor(s): Karli Rosner
Keywords(s): Anti-cancer, Cancer, Disease, Gene, Melanoma, Target, Therapeutics
Category(s): Life Science, Therapeutics, Diseases, Oncology, Biologicals, Genes
Modified Ectodomain of Human EGFR as a Potential Anticancer Agent
Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion o...
Published: 8/3/2017   |   Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu
Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics
Category(s): Life Science, Biologicals, Diseases, Oncology
Topical treatment with TGFbeta3 to facilitate skin and corneal wound healing in diabetic patients
Topical Treatment with TGFb3 to Facilitate Skin and Corneal Wound Healing in Diabetic Patients WSU Tech#: 14-1207 Technology Summary: TGFb3 has been implicated in the reduction of scar formation in wound healing. Renovo Group PLC, is a European based biopharmaceutical company developing drugs to reduce scaring, improve wound healing and enhance...
Published: 2/10/2017   |   Inventor(s): Fu-Shin Yu
Keywords(s):  
Category(s): Medical, Biologicals, Biomedical, Drug Discovery, Metabolic disorders, Protein/peptides, Therapeutics, Life Science
Topical IL-1Ra (anakinra) in the form of gel to treat persistent diabetic skin and corneal wounds
BackgroundAnakinra (aka. Kineret) is a recombinant human IL-1Ra that was developed by Amgen. It is currently used to treat moderately to severely active rheumatoid arthritis, but also treats neonatal-onset multisystem inflammatory disease (NOMID). Anakinra is given as an IV dose and the drug is no longer under patent. The properties of Anakinra a...
Published: 5/25/2016   |   Inventor(s): Fu-Shin Yu
Keywords(s):  
Category(s): Biologicals, Drug Discovery, Pharmaceuticals, Therapeutics
Antibacterial activity of natural compounds and their synthetic analogue: A potential new antibiotic with potent activity against multiple drug resistant bacterial pathogens
Our researchers have developed novel compounds that are potential antibiotics useful for treatment against the deadly bacteria MRSA (methicillin-resistant Staphylococcus aureus), VRE (vancomycin-resistant Enterococcus faecium), and several other well-known common infectious agents.Background & Unmet Need:Before antibiotics became available in t...
Published: 5/12/2015   |   Inventor(s): Fazlul Sarkar, Hossein Salimnia, Subhash Padhye, Bernhard Biersack
Keywords(s): Analog or Analogue, Antibiotics, Anti-infective, Anti-microbial, Disease
Category(s): Biologicals, Diseases, Infectious disease, Life Science, Therapeutics
Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases
Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC...
Published: 9/10/2012   |   Inventor(s): David Oupicky, Jing Li
Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics
Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals
Peptides Representing Genus-Specific Chlamydial Antigens for Vaccine Peptide Vaccines for Chlamydia to be Delivered Orally or by Other Mucosal Routes
Wayne State University inventors have developed several peptide Chlamydia vaccine candidates that are genus specific, conformational, and easy to manufacture. Background & Unmet Need: Despite increased surveillance and treatment, Chlamydial genital tract infections continue to rise. It is estimated that over 20 million new cases of infectio...
Published: 5/18/2010   |   Inventor(s): Judith Whittum-Hudson, Alan Hudson
Keywords(s): Vaccines
Category(s): Biologicals, Life Science, Therapeutics, Vaccines
Novel Mammalian Putative Phosphatidylinositol-4-Phosphate-5-Kinase
This invention is a novel mammalian gene involved in membrane trafficking, more specifically, insulin‑induced translocation of the fat/muscle-specific glucose transporter GLUT4. Background & Unmet Need: Both Type I (Juvenile onset) and Type II (Maturity onset) Diabetes Mellitus result in a profound state of high glucose in the circulatio...
Published: 5/18/2010   |   Inventor(s): Assia Shisheva
Keywords(s): DNA, Drug Target, Therapeutics
Category(s): Diseases, Life Science, Metabolic disorders, Therapeutics, Biologicals