Search Results - disease

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Inhibitors of the ubiquitin E3 ligase BCA2 as anti-cancer therapeutic agents

Background:Breast cancer associated protein 2 (BCA2) is a ubiquitin E3 ligase found in invasive breast cancer. Studies have shown that by decreasing its activity, breast cancer cell growth and invasiveness are diminished. Targeting this ligase and inhibiting its activity could play a role in treatment of breast cancer. A molecular approach to in...

Published: 8/3/2017 | Inventor(s): Angelika Burger, Andrew Westwell

Keywords(s): Analog or Analogue, Breast Cancer, Cancer, Disease, Drug Target, Enzyme

Category(s): Diseases, Oncology, Therapeutics, Life Science, Research tools

Novel Anti-Cancer Therapeutic Strategy to Overcome Cancer Resistance and to Enable Tailoring Treatment

This technology is a gene therapy construct based on modified programmed-cell-death genes involved in intracellular apoptosis. Bypassing the main treatment-resistant mechanisms of cancer offers a new direction, away from broad-spectrum treatments, towards individualized therapies for cancer treatment that carry fewer side-effects. Background &...

Published: 8/3/2017 | Inventor(s): Karli Rosner

Keywords(s): Anti-cancer, Cancer, Disease, Gene, Melanoma, Target, Therapeutics

Category(s): Life Science, Therapeutics, Diseases, Oncology, Biologicals, Genes

Modified Ectodomain of Human EGFR as a Potential Anticancer Agent

Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion o...

Published: 8/3/2017 | Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu

Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics

Category(s): Life Science, Biologicals, Diseases, Oncology

Antibacterial activity of natural compounds and their synthetic analogue: A potential new antibiotic with potent activity against multiple drug resistant bacterial pathogens

Our researchers have developed novel compounds that are potential antibiotics useful for treatment against the deadly bacteria MRSA (methicillin-resistant Staphylococcus aureus), VRE (vancomycin-resistant Enterococcus faecium), and several other well-known common infectious agents.Background & Unmet Need:Before antibiotics became available in t...

Published: 5/12/2015 | Inventor(s): Fazlul Sarkar, Hossein Salimnia, Subhash Padhye, Bernhard Biersack

Keywords(s): Analog or Analogue, Antibiotics, Anti-infective, Anti-microbial, Disease

Category(s): Biologicals, Diseases, Infectious disease, Life Science, Therapeutics

DNA Molecule Encoding the B3 Adrenegic Receptor

This technology describes the correct protein sequence of the β3 receptor to aid in the development of adult-onset diabetes drugs. Background & Unmet Need: The β3 receptor is currently being developed as a therapeutic target for human obesity and adult onset diabetes mellitus by several pharmaceutical companies. In order to develop...

Published: 5/18/2010 | Inventor(s): James Granneman, Kristine Lahners, Donald Rao

Keywords(s): Diabetes, Disease, DNA, Drug Target, Obesity, Therapeutics

Category(s): Life Science, Metabolic disorders, Diagnostics, Research tools, Receptors/targets