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Transgenic Mice Carrying Wild Type Human Her-2 Under the Whey Acidic Promoter
This technology is an animal model designed to help pharmaceutical and biotechnology industries develop Her-2 based vaccines or immunotherapeutic agents. Background & Unmet Need: Her-2 positive breast cancer is a breast cancer that is positive for a protein called human epidermal growth factor receptor 2 (Her-2). Presence of Her-2 promotes...
Published: 5/13/2025
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Inventor(s):
Wei-Zen Wei
,
Ye-Shih Ho
,
Marie Piechocki
Keywords(s):
Animal Model
,
Breast Cancer
,
Research Tool
Category(s):
Animal models
,
Life Science
,
Research tools
Generation of gp78 null mice
Generation of gp78 null mice WSU Tech#: 15-1291 Technology: Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis,...
Published: 11/22/2021
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Inventor(s):
Avraham Raz
,
Andrei Golovko
Keywords(s):
Category(s):
Animal models
,
Biology
,
Biomedical
,
Biotechnology
,
Drug Delivery
,
Drug Discovery
,
Drug Screening
,
Genomics/Genetics
,
Life Science
,
Oncology
,
Research tools