Search Results - animal+model

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Transgenic Mice Carrying Wild Type Human Her-2 Under the Whey Acidic Promoter

This technology is an animal model designed to help pharmaceutical and biotechnology industries develop Her-2 based vaccines or immunotherapeutic agents. Background & Unmet Need: Her-2 positive breast cancer is a breast cancer that is positive for a protein called human epidermal growth factor receptor 2 (Her-2). Presence of Her-2 promotes the...

Published: 3/2/2022 | Inventor(s): Wei-Zen Wei, Ye-Shih Ho, Marie Piechocki

Keywords(s): Animal Model, Breast Cancer, Research Tool

Category(s): Animal models, Life Science, Research tools

Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors

Background: Often referred to as the crucial "drug discovery tool", cell based technology is one of the most significant sectors of pharmaceutical research and development. Of particular importance has been the development of information-rich cellular assays that determine drug candidate efficacy and safety (target identification, validation...

Published: 4/17/2022 | Inventor(s): Leon Carlock, Maria Cypher

Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics

Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines, Oncology

Establishment of a Prostate Carcinoma Bone Tumor Model in Mice

This technology is a new tumorigenic cell line from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/IF, when implanted in the femurs of nude mice, provide a xenograft tumor model of bone metastatic prostate carcinoma. The PC-3/IF cell lines are highly tumorigenic, with tumor cells replacing the marrow cells in the bone...

Published: 12/6/2022 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Prostate Cancer, Research Tool

Category(s): Animal models, Life Science, Research tools, Oncology, Diseases

Establishment of a Metastatic Prostate Carcinoma Tumor Model in Mice

This technology is a new tumorigenic cell line from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/PI, are highly tumorigenic when implanted in the prostate of nude mice, providing a xenograft tumor model of prostate carcinoma. In this model, lymph node metastases form from the primary tumor, similar to what occurs in...

Published: 9/16/2019 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Prostate Cancer, Research Tool

Category(s): Animal models, Life Science, Oncology, Research tools, Diseases

Establishment of a New Renal Cell Carcinoma Cell Line and a New Experimental Renal Tumor Model

This technology is a tumor cell line from a primary papillary renal cell carcinoma that, when implanted in the kidney of nude mice, provides a xenograft tumor model of human renal cell carcinoma. Background & Unmet Need: Renal cell carcinoma, which occurs in the parenchyma of the kidney, is the most common type of renal cancer, accounting for approximately...

Published: 9/16/2019 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Research Tool

Category(s): Animal models, Life Science, Oncology, Research tools, Diseases