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Transgenic Mice Carrying Wild Type Human Her-2 Under the Whey Acidic Promoter

This technology is an animal model designed to help pharmaceutical and biotechnology industries develop Her-2 based vaccines or immunotherapeutic agents. Background & Unmet Need: Her-2 positive breast cancer is a breast cancer that is positive for a protein called human epidermal growth factor receptor 2 (Her-2). Presence of Her-2 promotes...

Published: 9/9/2024 | Inventor(s): Wei-Zen Wei, Ye-Shih Ho, Marie Piechocki

Keywords(s): Animal Model, Breast Cancer, Research Tool

Category(s): Animal models, Life Science, Research tools

Sentinel Cell

Sentry Cell (Macrophage Hazardous Material Detection) WSU Tech#: 10-991 Technology Summary: This technology is designed around an isolated cell system for the detection of an energetic material comprising of an isolated stationary macrophage cell isolated from a vestibular labyrinth of a Opsanus sp. This macrophage cell is plated in...

Published: 1/9/2023 | Inventor(s): Robert Silver

Keywords(s): Imaging, Process, Research Tool

Category(s): Process/Procedure, Biotechnology, Environment, Safety

Establishment of a Prostate Carcinoma Bone Tumor Model in Mice

This technology is a new tumorigenic cell line from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/IF, when implanted in the femurs of nude mice, provide a xenograft tumor model of bone metastatic prostate carcinoma. The PC-3/IF cell lines are highly tumorigenic, with tumor cells replacing the marrow cells in the bone...

Published: 12/6/2022 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Prostate Cancer, Research Tool

Category(s): Animal models, Life Science, Research tools, Oncology, Diseases

Establishment of a Metastatic Prostate Carcinoma Tumor Model in Mice

This technology is a new tumorigenic cell line from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/PI, are highly tumorigenic when implanted in the prostate of nude mice, providing a xenograft tumor model of prostate carcinoma. In this model, lymph node metastases form from the primary tumor, similar to what occurs in...

Published: 9/16/2019 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Prostate Cancer, Research Tool

Category(s): Animal models, Life Science, Oncology, Research tools, Diseases

Establishment of a New Renal Cell Carcinoma Cell Line and a New Experimental Renal Tumor Model

This technology is a tumor cell line from a primary papillary renal cell carcinoma that, when implanted in the kidney of nude mice, provides a xenograft tumor model of human renal cell carcinoma. Background & Unmet Need: Renal cell carcinoma, which occurs in the parenchyma of the kidney, is the most common type of renal cancer, accounting for approximately...

Published: 9/16/2019 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Research Tool

Category(s): Animal models, Life Science, Oncology, Research tools, Diseases

Microvascular Pericytes are Adult Pluripotential Stem Cells

WSU researchers have identified capillary pericytes, a cell type found in the central nervous system, as having pluripotent stem cell capabilities, which could be important to future research studies and therapeutic strategies. Background & Unmet Need: The presence of adult multipotent i.e., stem cells, has been demonstrated in a large number of...

Published: 9/17/2019 | Inventor(s): Paula Dore-Duffy, Xuegian Wang, Andre Katychev

Keywords(s): Research Tool

Category(s): Life Science, Research tools