Transgenic Mice Carrying Wild Type Human Her-2 Under the Whey Acidic Promoter

Case ID:

This technology is an animal model designed to help pharmaceutical and biotechnology industries develop Her-2 based vaccines or immunotherapeutic agents.


Background & Unmet Need:

Her-2 positive breast cancer is a breast cancer that is positive for a protein called human epidermal growth factor receptor 2 (Her-2).  Presence of Her-2 promotes the growth of cancer cells and is caused by a genetic mutation.  1 in 5 breast cancers are labelled as Her-2 positive; these types of cancers tend to be more aggressive and less responsive to hormone treatment. 


Technology Description:

WSU researchers have created a new animal model that can be used in cancer research.  The model expresses human Her-2, and the immune reactivity to Her-2 closely resembles that seen in humans.  Vaccines or immunotherapeutic agents targeting Her-2 can be tested in these mice to obtain meaningful pre-clinical data before clinical trials.


Commercial Applications:

  • Animal model for testing Her-2 vaccines or immunotherapeutic agents

Stage of Development:



Competitive Advantages:

  • Animals tolerant to Her-2 and exhibit immune responses similar to those seen in humans


Intellectual Property Status:

No patent information available


Related Publications or Citations of Work:

Piechocki, M.P., Ho, Y.S., Pilon, A. and Wei, W.Z. Human ErbB-2 (Her-2) transgenic mice: A model system for testing Her-2 based vaccines, J. Immunol. 171: 5787-5794, 2003.

Patent Information:
For Information, Contact:
Nicole Grynaviski
Commercialization Principal
Wayne State University
Wei-Zen Wei
Ye-Shih Ho
Marie Piechocki
Animal Model
Breast Cancer
Research Tool